Early life low intensity stress experience modifies acute stress effects on juvenile brain cell proliferation of European sea bass ( D. Labrax )

Fokos, S.; Pavlidis, M.; Yiotis, T.; Tsalafouta, A.; Papandroulakis, Nikos; Dermon, Catherine R.

doi:10.1016/j.bbr.2016.09.026

Cited by 19 publications

(12 citation statements)

References 102 publications

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“…This result could indicate a stronger switching away from growth and toward coping with stress following stressful events in EPH treated fish, a strategy that might benefit the recovery of the fish and ultimately provide a better long-term growth response, but more data on temporal changes in the expression of genes in the somatotropic and HPI axes in EPH treated fish is needed to test this hypothesis. A similar pattern has been observed before in response to chronic stress in salmon and sea bass (Moghadam et al 2017; Fokos et al 2017; Vindas et al 2016). Up-stream positive and negative feedback regulators of gh expression, such as gonadotrophin-releasing hormone and preproghrelin-1 and 2 (Lim et al 2014), tended to show reduced expression in all treatment and control groups.…”

Section: Discussionsupporting

confidence: 88%

Early Developmental Stress Affects Subsequent Gene Expression Response to an Acute Stress in Atlantic Salmon: An Approach for Creating Robust Fish for Aquaculture?

Robinson

Johnsen

Moghadam

et al. 2019

G3 Genes|Genomes|Genetics

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Stress during early life has potential to program and alter the response to stressful events and metabolism in later life. Repeated short exposure of Atlantic salmon to cold water and air during embryonic (E), post-hatch (PH) or both phases of development (EPH) has been shown to alter the methylome and transcriptome and to affect growth performance during later life compared to untreated controls (CO). The aim of this study was to investigate how the transcriptome of these fish responds to subsequent acute stress at the start feeding stage, and to describe methylation differences that might steer these changes. EPH treated fish showed the strongest down-regulation of corticotropin releasing factor 1, up-regulation of glucocorticoid receptor and 3-oxo-5-alpha-steroid 4-dehydrogenase 2 gene expression and a suppressed cortisol response 3 hr after the acute stress, differences that could influence hormesis and be affecting how EPH fish cope and recover from the stress event. Growth hormone 2 and insulin-like growth factor 1 were more strongly down-regulated following acute stress in EPH treated fish relative to E, PH and CO fish. This indicates switching away from growth toward coping with stress following stressful events in EPH fish. Genes implicated in immune function such as major histocompatibility class 1A, T-cell receptor and toll-like receptor also responded to acute stress differently in EPH treated fish, indicating that repeated stresses during early life may affect robustness. Differential DNA methylation was detected in regions mapping <500 bases from genes differentially responding to acute stress suggesting the involvement of epigenetic mechanisms. Stress treatments applied during early development therefore have potential as a husbandry tool for boosting the productivity of aquaculture by affecting how fish respond to stresses at critical stages of production.

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Section: Discussionsupporting

confidence: 88%

Early Developmental Stress Affects Subsequent Gene Expression Response to an Acute Stress in Atlantic Salmon: An Approach for Creating Robust Fish for Aquaculture?

Robinson

Johnsen

Moghadam

et al. 2019

G3 Genes|Genomes|Genetics

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“…Consistent with the distinct roles for different components of the stress axis (Greenwood et al, 2003), our results show differences in expression patterns across HPI axis candidate genes . GR1, specifically, appears to respond to the early-life social environment in A. burtoni and other teleost species (Fokos et al, 2017;Nyman et al, 2018Nyman et al, , 2017Taborsky et al, 2013). In the group-living cichlid N. pulcher, for example, increased early-life social complexity led to altered GR1 expression, but not GR2 or MR expression, in whole brain and telencephalon (Nyman et al, 2018(Nyman et al, , 2017Taborsky et al, 2013).…”

Section: Early-life Social Environment and Treatment Duration Affect Neuroendocrine Gene Expressionmentioning

confidence: 97%

Early-life social environment alters juvenile behavior and neuroendocrine function in a highly social cichlid fish

Solomon‐Lane

Hofmann

2019

Hormones and Behavior

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Early-life experiences can shape adult behavior, with consequences for fitness and health, yet fundamental questions remain unanswered about how early-life social experiences are translated into variation in brain and behavior. The African cichlid fish Astatotilapia burtoni, a model system in social neuroscience, is well known for its highly plastic social phenotypes in adulthood. Here, we rear juveniles in either social groups or pairs to investigate the effects of early-life social environments on behavior and neuroendocrine gene expression. We find that both juvenile behavior and neuroendocrine function are sensitive to early-life effects. Behavior robustly co-varies across multiple contexts (open field, social cue investigation, and dominance behavior assays) to form a behavioral syndrome, with pair-reared juveniles towards the end of syndrome that is less active and socially interactive. Pair-reared juveniles also submit more readily as subordinates. In a separate cohort, we measured whole brain expression of stress and sex hormone genes. Expression of glucocorticoid receptor (GR) 1a was elevated in group-reared juveniles, supporting a highly-conserved role for the stress axis mediating early-life effects. The effect of rearing environment on androgen receptor (AR)  and estrogen receptor (ER)  expression was mediated by treatment duration (1 vs. 5 weeks). Finally, expression of corticotropin-releasing factor (CRF) and GR2 decreased significantly over time. Rearing environment also caused striking differences in gene co-expression, such that expression was tightly integrated in pair-reared juveniles, but not group-reared or isolates. Together, this research demonstrates the important developmental origins of behavioral phenotypes and identifies potential behavioral and neuroendocrine mechanisms.

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“…The biological processes by which stress physiology and fish physiology in general are altered in the long term due to prior exposure to elevated temperature are not yet fully understood. Sustained changes in brain monoaminergic signalling and neural plasticity in specific areas or epigenetic modifications may contribute to observed effects (Fokos et al ., 2017; Vindas et al ., 2018; Zhang et al ., 2010). In the context of global warming, epigenetic modifications may be induced by exposure to elevated temperature (Anastasiadi et al ., 2017; Bizuayehu et al ., 2015; Jonsson & Jonsson, 2019) that can later mediate the coping ability of individuals on stress.…”

Section: Global Warming and Fish Stress Physiologymentioning

confidence: 99%

Temperature increase and its effects on fish stress physiology in the context of global warming

Alfonso

Gesto

Sadoul

2020

Journal of Fish Biology

330

141

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The capacity of fishes to cope with environmental variation is considered to be a main determinant of their fitness and is partly determined by their stress physiology.By 2100, global ocean temperature is expected to rise by 1-4 C, with potential consequences for stress physiology. Global warming is affecting animal populations worldwide through chronic temperature increases and an increase in the frequency of extreme heatwave events. As ectotherms, fishes are expected to be particularly vulnerable to global warming. Although little information is available about the effects of global warming on stress physiology in nature, multiple studies describe the consequences of temperature increases on stress physiology in controlled laboratory conditions, providing insight into what can be expected in the wild. Chronic temperature increase constitutes a physiological load that can alter the ability of fishes to cope with additional stressors, which might compromise their fitness. In addition, rapid temperature increases are known to induce acute stress responses in fishes and might be of ecological relevance in particular situations. This review summarizes knowledge about effects of temperature increases on the stress physiology of fishes and discusses these in the context of global warming.

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Early life low intensity stress experience modifies acute stress effects on juvenile brain cell proliferation of European sea bass ( D. Labrax )

Cited by 19 publications

References 102 publications

Early Developmental Stress Affects Subsequent Gene Expression Response to an Acute Stress in Atlantic Salmon: An Approach for Creating Robust Fish for Aquaculture?

Early Developmental Stress Affects Subsequent Gene Expression Response to an Acute Stress in Atlantic Salmon: An Approach for Creating Robust Fish for Aquaculture?

Early-life social environment alters juvenile behavior and neuroendocrine function in a highly social cichlid fish

Temperature increase and its effects on fish stress physiology in the context of global warming

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