Early life overnutrition induced by litter size manipulation decreases social play behavior in adolescent male rats

Carvalho, Ana Laura O.; Ferri, B.; Sousa, Francielly A. Lopes de; Vilela, Fabiana C.; Giusti‐Paiva, Alexandre

doi:10.1016/j.ijdevneu.2016.07.005

Cited by 26 publications

(12 citation statements)

References 67 publications

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“…Postnatal early nutrition, especially breast-feeding, is essential to infant development, protecting against obesity and metabolic dysfunction in later life 19 . Studies have shown that human milk contains high concentrations of bioactive substances such as proteins, peptides, steroids, growth factors and hormones, including insulin 20 – 23 .…”

Section: Discussionmentioning

confidence: 99%

Maternal low intensity physical exercise prevents obesity in offspring rats exposed to early overnutrition

Ribeiro

Tófolo

Martins

et al. 2017

Sci Rep

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Low intensity exercise during pregnancy and lactation may create a protective effect against the development of obesity in offspring exposed to overnutrition in early life. To test these hypotheses, pregnant rats were randomly assigned into 2 groups: Sedentary and Exercised, low intensity, on a rodent treadmill at 30% VO2Max /30-minute/session/3x/week throughout pregnancy and the lactation. Male offspring were raised in small litters (SL, 3 pups/dam) and normal litters (NL, 9 pups/dam) as models of early overnutrition and normal feed, respectively. Exercised mothers showed low mesenteric fat pad stores and fasting glucose and improved glucose-insulin tolerance, VO2max during lactation and sympathetic activity. Moreover, the breast milk contained elevated levels of insulin. In addition, SL of sedentary mothers presented metabolic dysfunction and glucose and insulin intolerance and were hyperglycemic and hyperinsulinemic in adulthood. SL of exercised mothers showed lower fat tissue accretion and improvements in glucose tolerance, insulin sensitivity, insulinemia and glycemia. The results suggest that maternal exercise during the perinatal period can have a possible reprogramming effect to prevent metabolic dysfunction in adult rat offspring exposed to early overnutrition, which may be associated with the improvement in maternal health caused by exercise.

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Section: Discussionmentioning

confidence: 99%

Maternal low intensity physical exercise prevents obesity in offspring rats exposed to early overnutrition

Ribeiro

Tófolo

Martins

et al. 2017

Sci Rep

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“…Another study showed that the moderate recurrent hypoglycemia during the pre-weaning period led to abnormal responses to stress and decreases in adolescent social play behavior 60 . Conversely, early postnatal overnutrition was associated with decreases in social play behavior in adolescent male rats 61 .…”

Section: Discussionmentioning

confidence: 88%

Peripubertal stress increases play fighting at adolescence and modulates nucleus accumbens CB1 receptor expression and mitochondrial function in the amygdala

et al. 2018

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Play fighting is a highly rewarding behavior that helps individuals to develop social skills. Early-life stress has been shown to alter play fighting in rats and hamsters as well as to increase aggressive behaviors at adulthood. However, it is not known whether individual differences in stress-induced play fighting are related to differential developmental trajectories towards adult aggression. To address this question, we used a rat model of peripubertal stress (PPS)-induced psychopathology that involves increased aggression at adulthood. We report that, indeed, PPS leads to enhanced play fighting at adolescence. Using a stratification approach, we identify individuals with heightened levels of play fighting as the ones that show abnormal forms of aggression at adulthood. These animals showed as well a rapid habituation of their corticosterone responsiveness to repeated stressor exposure at peripuberty. They also showed a striking increase in mitochondrial function in the amygdala—but not nucleus accumbens—when tested ex vivo. Conversely, low, but not high players, displayed increased expression of the CB1 cannabinoid receptor in the nucleus accumbens shell. Our results highlight adolescence as a potential critical period in which aberrant play fighting is linked to the emergence of adult aggression. They also point at brain energy metabolism during adolescence as a possible target to prevent adult aggression.

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“…During each session, maternal behavior was scored every 3 min (25 observations per four periods per day for a total of 100 observations per dam per day). Six maternal behaviors and three non‐maternal behaviors were recorded as follows: (1) licking the pups (either the body surface or the anogenital region), (2) nursing the pups in an arched‐back posture, (3) “blanket” posture in which the mother lays over the pups, (4) passive posture in which the mother lies either on her back or side while the pups nurse, (5) self‐grooming in which dams lick the breasts, (6) nest building, (7) feeding, (8) exploring the cage housing, (8) not exploring (Costa et al, 2013; Carvalho et al, 2016). Behavioral data are reported as percentages of the total number of behavioral observations (number of target behavior observations divided by the total number of all behavioral observations × 100).…”

Section: Methodsmentioning

confidence: 99%

“…The mean number of days required for the appearance of each of the above‐mentioned parameters was calculated. On PND 21, the offspring were weaned, marked with a nontoxic ink, distributed in accordance with their sex, and housed in groups of four per cage (Carvalho et al, 2016; Veronesi et al, 2017).…”

Section: Methodsmentioning

confidence: 99%

Cafeteria diet during the gestation period programs developmental and behavioral courses in the offspring

Ribeiro

Batista

Veronesi

et al. 2018

Intl J of Devlp Neuroscience

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The objective of this study was to investigate the effect of exposure to maternal consumption of a hyperenergetic, highly palatable diet, known as the cafeteria diet, during the gestation period on the development and behavior of offspring. For this, we used pregnant female mice that were fed a normal or a cafeteria diet during the gestation period. The evaluation of maternal behavior in lactating dams was performed from the second to the eighth day postpartum (PND 2-8). Weight gain, feed intake, and energy intake were recorded during the gestation period. In the offspring, reflex parameters and physical development were evaluated during the lactation period and when they reached adolescence. Behavioral performance was evaluated in light-dark, open-field, and play behavior tests. In addition, biochemical parameters of the dams and the adolescent offspring were evaluated. The cafeteria diet during gestation altered maternal behavior and the onset of physical and neurodevelopmental landmarks and had an impact on emotional and play behavior in adolescent offspring. In conclusion, our results demonstrate that exposure to maternal consumption of a cafeteria diet during the gestation period can program developmental and behavioral courses in the offspring.

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Early life overnutrition induced by litter size manipulation decreases social play behavior in adolescent male rats

Cited by 26 publications

References 67 publications

Maternal low intensity physical exercise prevents obesity in offspring rats exposed to early overnutrition

Maternal low intensity physical exercise prevents obesity in offspring rats exposed to early overnutrition

Peripubertal stress increases play fighting at adolescence and modulates nucleus accumbens CB1 receptor expression and mitochondrial function in the amygdala

Cafeteria diet during the gestation period programs developmental and behavioral courses in the offspring

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