Early-life persistent vitamin D deficiency-induced cardiovascular dysfunction in mice is mediated by transient receptor potential C channels

Stratford, Kimberly; Haykal-Coates, Najwa; Thompson, L. C.; Farraj, Aimen K.; Hazari, Mehdi S.

doi:10.1016/j.jsbmb.2020.105804

Cited by 3 publications

(2 citation statements)

References 53 publications

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“…Experimental animal models have suggested that vitamin D deficiency triggers the renin-angiotensin system, contributing to the onset of high blood pressure and arterial plaque buildup [27][28].…”

Section: Research Questionsmentioning

confidence: 99%

Addressing vitamin D deficiency through nutritional strategies

Trachtenberg,

Martirosyan

2024

BCHD

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This review explores the multifaceted impacts of vitamin D deficiency on overall health and investigates diverse strategies for addressing this issue. Vitamin D deficiency presents a global health issue with notable implications for cardiovascular, immune, and brain health. Strategies to address deficiency encompass dietary modifications, food fortification, and supplementation. Serum 25(OH)D concentration serves as a crucial biomarker, with levels below 20 ng/mL being indicative of deficiency. Tailored supplementation regimens, often favoring vitamin D3 for its enhanced bioavailability, necessitate careful consideration to avoid toxicity risks. The incorporation of vitamin D-fortified foods into dietary patterns presents a promising systematic approach to mitigating deficiency and promoting overall health. The Functional Food Center's regulatory process offers a structured framework for creating products fortified with vitamin D, emphasizing the importance of regulatory compliance and clinical validation. While existing evidence underscores the efficacy of fortified products, ongoing epidemiological and post-market research is imperative to fully establish their status as functional foods. Keywords: Vitamin D, deficiency, fortification, dietary intake, supplementation, bioactive compounds, functional foods

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Section: Research Questionsmentioning

confidence: 99%

Addressing vitamin D deficiency through nutritional strategies

Trachtenberg,

Martirosyan

2024

BCHD

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“…Chronic vitamin D deficiency may predispose to hypertension, and one mechanism recently identified characterizing this direct cardiac effects is the modulation of the function of transient receptor potential C cation channels, which is a mechanosensitive cation channel that plays a role in cardiac slow-force responses to hemodynamic changes ( Stratford et al, 2021 ). Moreover, vitamin D has direct effects on the atrial electrophysiology and atrial fibrillation, a direct association with regulation of cardiac autonomic activity, and a direct role in the regulation of vasomotor inducing changes of pressor and depressor vasomotor responses ( Mann et al, 2013 ; Hanafy et al, 2014 ).…”

Section: Vitamin D and Cv Pathophysiologymentioning

confidence: 99%

Vitamin D, Thyroid Hormones and Cardiovascular Risk: Exploring the Components of This Novel Disease Triangle

et al. 2021

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The role of thyroid hormones (THs) in the cardiovascular (CV) system, through several direct and indirect effects is recognized. Even very small modification in TH levels (as those observed in subclinical hypothyroidism or hyperthyroidism, and low triiodothyronine syndrome) may adversely affect the CV system, whereas thyroid hormones benefit the CV system and improve the prognosis. There is also evidence of vitamin D effects on cardiometabolic disease (e.g., through modulation of endothelial and smooth muscle cell activity, renin-angiotensin-aldosterone system, nitric oxide, oxidative stress, and inflammatory response), as well as an association between vitamin D [25(OH)D] deficiency and autoimmune thyroid diseases or cancer, and a relationship between vitamin D concentration and titers of antibodies and thyroid autoimmunity replacement. Interestingly, experimental data indicate a direct effect of vitamin D on Type 2 deiodinase expression causing subsequential peripheral conversion of T4 into T3. However, the functional links among THs, vitamin D and the cardiovascular system, and clinical effects of coexisting abnormalities in this new troublesome triad, have not yet been reviewed. The main aim of this review is to discuss pathophysiology of this relationship, proposing new mechanistic insights involving vitamin D in the modulation of cardiometabolic disease and thyroid profile.

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Genomic and non-genomic action of vitamin D on ion channels – Targeting mitochondria

Olszewska,

Zmijewski

2024

Mitochondrion

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Early-life persistent vitamin D deficiency-induced cardiovascular dysfunction in mice is mediated by transient receptor potential C channels

Cited by 3 publications

References 53 publications

Addressing vitamin D deficiency through nutritional strategies

Addressing vitamin D deficiency through nutritional strategies

Vitamin D, Thyroid Hormones and Cardiovascular Risk: Exploring the Components of This Novel Disease Triangle

Genomic and non-genomic action of vitamin D on ion channels – Targeting mitochondria

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