Early-life prevention of non-communicable diseases

Balbus, John; Barouki, Robert; Birnbaum, Linda S.; Etzel, Ruth A.; Gluckman, Peter D.; Grandjean, Philippe; Hancock, Christine; Hanson, Mark A.; Heindel, Jerrold J.; Hoffman, Kate; Jensen, Génon K.; Keeling, Ann; Neira, María; Rabadan‐Diehl, Cristina; Ralston, Johanna; Tang, Kwok Cho

doi:10.1016/s0140-6736(12)61609-2

Cited by 149 publications

(100 citation statements)

References 8 publications

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“…The low prevalence of EB may have negative repercussions for the burden of disease in the Region. There is evidence that proper early infant nutrition may play an important role in the prevention of NCDs throughout life (128). EB in the first 6 months of life ensures adequate mental development and optimal physical growth, metabolic regulation and immunity (129).…”

Section: Discussionmentioning

confidence: 99%

Review of the nutrition situation in the Eastern Mediterranean Region

Nasreddine

Ayoub

Al-Jawaldeh

2018

East Mediterr Health J

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Section: Discussionmentioning

confidence: 99%

Review of the nutrition situation in the Eastern Mediterranean Region

Nasreddine

Ayoub

Al-Jawaldeh

2018

East Mediterr Health J

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“…6 Because of its phenotypic plasticity, the fetus and neonate are highly susceptible to several insults, including hypoxia, nutritional disturbances, and hormonal influences. 6 By extension, this period of increased vulnerability also reflects a time in which offspring may be most amenable to therapeutics, 7 such that targeted interventions may provide lasting benefits, even after treatment cessation.…”

mentioning

confidence: 99%

Perinatal Resveratrol Supplementation to Spontaneously Hypertensive Rat Dams Mitigates the Development of Hypertension in Adult Offspring

et al. 2016

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ypertension is an important and modifiable risk factor for cardiovascular disease, affecting ≈1 in 4 adults worldwide. 1 In the United States, hypertension is estimated to account for >$46 billion annually in healthcare services, medication, and lost productivity, 2 and these costs are expected to increase substantially over the coming decades. A universal consensus is that prevention, rather than treatment, is a more strategic and cost-effective approach to reducing the burden of cardiovascular disease in coming decades.Essential hypertension, in which known primary causes (eg, renovascular disease, pheochromocytoma, monogenic causes, etc) are not present, makes up 95% of hypertension worldwide.3 Although the pathogenesis of essential hypertension is multifactorial and complex, subclinical changes in vascular function often precede the development of hypertension and circulatory decline. 4 The spontaneously hypertensive rat (SHR) is a model of essential hypertension in which blood pressure (BP) begins to rise after 6 weeks of age, ultimately reaching stable pressures of ≈180 to 200 mm Hg. Recently, Komolova et al reported evidence of altered vascular resistance profiles and renal hemodynamics as early as 3 weeks of age in the SHR, 5 implicating these early functional changes as a cause, rather than a consequence, of hypertension in this model. As such, the developmental period before weaning (ie, See Editorial Commentary, pp 829-830Abstract-This study was undertaken to determine whether perinatal maternal resveratrol (Resv)-a phytoalexin known to confer cardiovascular protection-could prevent the development of hypertension and improve vascular function in adult spontaneously hypertensive rat offspring. Dams were fed either a control or Resv-supplemented diet (4 g/kg diet) from gestational day 0.5 until postnatal day 21. Indwelling catheters were used to assess blood pressure and vascular function in vivo; wire myography was used to assess vascular reactivity ex vivo. Perinatal Resv supplementation in dams had no effect on fetal body weights, albeit continued maternal treatment postnatally resulted in growth restriction in offspring by postnatal day 21; growth restriction was no longer evident after 5 weeks of age. Maternal perinatal Resv supplementation prevented the onset of hypertension in adult offspring (−18 mm Hg; P=0.007), and nitric oxide synthase inhibition (with l-NG-nitroarginine methyl ester) normalized these blood pressure differences, suggesting improved nitric oxide bioavailability underlies the hemodynamic alterations in the Resv-treated offspring. In vivo and ex vivo, vascular responses to methylcholine were not different between treatment groups, but prior treatment with l-NG-nitroarginine methyl ester attenuated the vasodilation in untreated, but not Resv-treated adult offspring, suggesting a shift toward nitric oxide-independent vascular control mechanisms in the treated group. Finally, bioconversion of the inactive precursor big endothelin-1 to active endothelin-1 in isolated mesenteric art...

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“…Ils se révéleront plusieurs années plus tard par une susceptibilité particulière des enfants exposés au mode de vie qui sera le leur et à de nouveaux environnements bénéfiques ou délétères. Certaines expositions environnementales affectent l'expression de nos gènes et conditionnent notre susceptibilité ou notre résistance aux maladies chroniques [1]. Les effets dépendent en fait d'interactions complexes entre expositions environnementales multiples et cumulées, conditions psycho-affectives, travail, stress, nutrition, et susceptibilités génétiques.…”

Section: Environnements Précoces Origines Précoces De La Santé Et Deunclassified

Environnements précoces, origines précoces de la santé et des maladies

Drisse

2016

Med Sci (Paris)

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Early-life prevention of non-communicable diseases

Cited by 149 publications

References 8 publications

Review of the nutrition situation in the Eastern Mediterranean Region

Review of the nutrition situation in the Eastern Mediterranean Region

Perinatal Resveratrol Supplementation to Spontaneously Hypertensive Rat Dams Mitigates the Development of Hypertension in Adult Offspring

Environnements précoces, origines précoces de la santé et des maladies

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