Early life programming of attention capacity in adolescents: The HELENA study

Esteban‐Cornejo, Irene; Henriksson, Pontus; Cadenas‐Sanchez, Cristina; Vanhelst, Jérémy; Forsner, Maria; Gottrand, Frédéric; Kersting, Mathilde; Moreno, Luís A.; Ruiz, Jonatan R.; Widhalm, Kurt; Ortega, Francisco B.

doi:10.1111/mcn.12451

Cited by 5 publications

(2 citation statements)

References 46 publications

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“…It is known that during the lactation period breastfeeding is important not only for the nourishment of the offspring but also for the development of endocrine, neural, immune, psychological systems, and sensorial, executive and behavioral functions (Agosti et al., 2017; Ballard & Morrow, 2013; Esteban‐Cornejo et al., 2017; Koletzko, 2005). However, less than 40% of children globally are exclusively breastfed during the first 6 months of life (WHO, 2015).…”

Section: Discussionmentioning

confidence: 99%

Early weaning alters redox status in the hippocampus and hypothalamus of rat pups

Klein

August

Santos

et al. 2020

Intl J of Devlp Neuroscience

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Exposure to environmental factors can program the metabolism, conferring resistance or increasing the risk to chronic disease development in childhood and adulthood. In this sense, lactation is an important period in this window of development. Herein, we investigated the effect of early weaning on neurochemical and behavioral changes in offspring at weaning and adulthood. Female and male pups were divided into four groups: (1) Control weaning (weaning on the PND21, pups were kept with the biological mother); (2) Early Weaning Bromocriptine group (EWB) (pharmacological weaning on PND16); (3) Early Weaning Cross-Fostering group (EWCF) (pups housed with a foster mother on PND16 up to PND21); (4) Early Weaning Without Care group (EWWC) (weaning on PND16, maternal separation). Weight control of pups was recorded from postnatal Day 16 to 59. On the 21st day, part of the pups was euthanized and the hippocampus and hypothalamus were removed for biochemical evaluation. The remaining pups were submitted to behavioral tests on the 60th postnatal day. Early weaning reduced the pups' body weight, in a sexdependent way. At 60 days of age, male pups of EWCF and EWWC groups have lower body weight compared to control male, and female body weight was lower than male pups. In relation to biochemical changes in the brain, weaning altered the levels of oxidants, increased the enzymatic activity of superoxide dismutase (SOD), and glutathione peroxidase (GPx), as well as induced lipid peroxidation. Weaning was also able to alter long-term memory and induce anxious behavior in pups. Our results demonstrate that the different types of early weaning changed the parameters of redox status in the hippocampus and hypothalamus of pups (21 days old), suggesting a prooxidative profile, in addition, to alter learning/memory and inducing an anxious behavior in male offspring (60 days old).

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Section: Discussionmentioning

confidence: 99%

Early weaning alters redox status in the hippocampus and hypothalamus of rat pups

Klein

August

Santos

et al. 2020

Intl J of Devlp Neuroscience

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“…Some studies have explored the association of dietary patterns and of specific food components with attention in adolescence [34][35][36]. Early life factors such as birth weight and exclusive breastfeeding have also been associated with attention in adolescents [37].…”

Section: Factors Associated With Attentionmentioning

confidence: 99%

Identifying Factors Influencing Attention in Adolescents with a Co-Created Questionnaire: A Citizen Science Approach with Secondary Students in Barcelona, Spain

Gignac

Solé

Barrera-Gómez

et al. 2021

IJERPH

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Studies on factors that can influence attention in healthy adolescents are recent and focus on recurrent topics. Students’ contribution to public health research often revolves around collecting data but rarely around creating data collection instruments. The ATENC!Ó project reunited secondary students and scientists to create a questionnaire including factors that students thought could affect their attention. We conducted a cross-sectional study to assess whether the factors included in this questionnaire had an effect on attention in adolescents. A total of 1667 students (13–16 years old) from 28 schools in Barcelona performed a validated attention test and answered the questionnaire. The response speed consistency (attentiveness), expressed as hit reaction time standard error (HRT-SE, in ms), was used as the primary outcome. Analyses were conducted using conditional linear regression with school as strata, adjusted for sociodemographic characteristics and further stratified by gender and maternal social class. Some factors showed a negative influence on attention, including taking medication and not reading regularly. We found a significant 14.3% (95% confidence interval: 3.4%, 25.3%) higher median of HRT-SE (increase inattentiveness) among students who reported not having a good relationship with classmates. Students’ input into research is relevant for advancing the knowledge production in public health.

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Attention capacity in European adolescents: role of different health-related factors. The HELENA study

Esteban‐Cornejo¹,

Cadenas‐Sanchez²,

Vanhelst³

et al. 2017

Eur J Pediatr

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Adolescents from the south of Europe had higher levels of attention capacity than their counterparts from central Europe independently of sociodemographic and health-related factors. These differences should be taken into account by educational institutions when promoting new approaches for putting into the practice student's capacities. What is Known? • Attention is a crucial capacity during adolescence. • Several health-related factors (i.e., physical activity, fitness or fatness) may influence attention capacity in adolescents. What is New? • Adolescents from the south of Europe had higher levels of attention capacity than their counterparts from the center, after accounting for socioeconomic factors, fitness, fatness and quality of diet. • These differences should be taken into account by educational institutions when promoting new approaches for putting into the practice student's capacities.

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Early life programming of attention capacity in adolescents: The HELENA study

Cited by 5 publications

References 46 publications

Early weaning alters redox status in the hippocampus and hypothalamus of rat pups

Early weaning alters redox status in the hippocampus and hypothalamus of rat pups

Identifying Factors Influencing Attention in Adolescents with a Co-Created Questionnaire: A Citizen Science Approach with Secondary Students in Barcelona, Spain

Attention capacity in European adolescents: role of different health-related factors. The HELENA study

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