2020
DOI: 10.1016/s2214-109x(20)30251-5
|View full text |Cite|
|
Sign up to set email alerts
|

Early-life respiratory syncytial virus lower respiratory tract infection in a South African birth cohort: epidemiology and effect on lung health

Abstract: Summary Background Respiratory syncytial virus (RSV) is a major cause of lower respiratory tract infection (LRTI) in children. Early-life RSV LRTI might affect long-term health but there are few data from low-income and middle-income countries. We investigated the epidemiology and effect of early-life RSV LRTI on lung health in a South African birth cohort. Methods We conducted the Drakenstein Child Health Study (DCHS), an ongoing birth cohort longitudinal … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

10
65
1

Year Published

2021
2021
2023
2023

Publication Types

Select...
5
2

Relationship

0
7

Authors

Journals

citations
Cited by 73 publications
(76 citation statements)
references
References 30 publications
10
65
1
Order By: Relevance
“…From March 2012 to March 2015, 1137 pregnant women were enrolled; there were 1143 live births. Risk factors for and incidence of pneumonia in the cohort have been described [9,10]. In the first 2 years of life there were 174 episodes of hospitalized pneumonia.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…From March 2012 to March 2015, 1137 pregnant women were enrolled; there were 1143 live births. Risk factors for and incidence of pneumonia in the cohort have been described [9,10]. In the first 2 years of life there were 174 episodes of hospitalized pneumonia.…”
Section: Resultsmentioning
confidence: 99%
“…We previously described incidence, severity and risk factors for pneumonia [9] and respiratory syncytial virus (RSV) pneumonia [10] in children under 2 years of age in the Drakenstein Child Health Study (DCHS), a birth cohort in South Africa. In this paper, we describe factors associated with pneumonia mortality or ICU admission in the first 2 years of life, and test whether the risk factors included in the PERCH severity score were associated with death or ICU admission in this cohort.…”
Section: Introductionmentioning
confidence: 99%
“…Data from a South African birth cohort suggest that lower respiratory tract infections in infancy are associated with decreased lung function and recurrent wheeze. 27,28 Several different biological mechanisms could explain the association between pneumonia diagnosis and asthma, including direct damage to the lung parenchyma, immunomodulatory mechanisms, or disturbance of lung development during a critical phase. In mouse models, pneumococcal pneumonia has been shown to alter the expression of airway smooth muscle proteins, whereas RSV infection has been associated with immune modulation and airway hyperresponsiveness.…”
Section: Discussionmentioning
confidence: 99%
“…A causal relationship between early life RSV LRTI and recurrent wheeze or asthma is hard to establish since both syndromes are complex and risk factors should be weighted differently for specific phenotypes and endotypes [8]. Still, there is a significant impact of RSV‐LRTI in the first year of life on recurrent wheeze, especially in the pre‐school years with tracking of low lung function values [9]. There are important implications for RSV prevention strategies, especially regarding any potential long‐term benefit from prophylaxis aimed at reducing post‐RSV recurrent wheezing and asthma [7].…”
Section: Sanofi‐pasteur Satellite Symposiummentioning
confidence: 99%