Early-life stress and antidepressants modulate peripheral biomarkers in a gene–environment rat model of depression

Carboni, Lucia; Becchi, Serena; Piubelli, Chiara; Mallei, Alessandra; Giambelli, R.; Razzoli, Maria; Mathé, Aleksander A.; Popoli, Maurizio; Domenici, Enrico

doi:10.1016/j.pnpbp.2010.05.019

Cited by 85 publications

(67 citation statements)

References 64 publications

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“…161 Differences were also found between the FSL and FRL rats in the serum levels of proteins involved in lipid metabolism and immunity. 162 Although the straight-forward interpretation of these findings is difficult, it appears that stressful conditions during the early developmental phase have different effects on brain development, as well as the behavioural phenotype, at the adult stage, in the FSL rats and the normal controls.…”

Section: Depression As a Results Of Gene-environment Interactionmentioning

confidence: 99%

Neurochemical and Behavioural Changes in Rat Models of Depression

Skelin¹,

Kovačević²,

Dikšić³

2011

Croat. Chem. Acta

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Abstract. Depression is one of the most prevalent psychiatric disorders with significant lifetime prevalence. The study of human depression is hindered by the relatively significant heterogeneity of this disorder. As a result of these heterogeneities, studies using a sound and representative animal model of depression are extremely valuable and, in general, provide important information regarding the neurochemical/biological changes occurring during depression and the subsequent treatment of its symptoms. In this review we concentrate on two solid rat models of depression: olfactory bulbectomized (OBX) rats and Flinders Sensitive Line (FSL) of rats. These two models were selected because they possess all three characteristics of a good animal model; face, predictive and constructive validities. We also emphasize the brain serotonergic system and we discuss the open field and forced swim test to assess behaviour. (doi: 10.5562/cca1817) Keywords: depression, olfactory bulbectomized rat model of depression, Flinders sensitive line rat, Flinders Resistant line rat, animal model of depression

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Section: Depression As a Results Of Gene-environment Interactionmentioning

confidence: 99%

Neurochemical and Behavioural Changes in Rat Models of Depression

Skelin¹,

Kovačević²,

Dikšić³

2011

Croat. Chem. Acta

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“…The results are extremely complex, but in sum, differences were reported to be dependent upon both the genetic factor (strain differences) and to the environmental factor (maternal deprivation) (Carboni et al, 2010).…”

Section: Recent and Current Researchmentioning

confidence: 99%

“…Other studies have used proteomic strategies to develop a global pattern of changes in the FSL rat after chronic antidepressant treatment and/or early maternal separation (Piubelli et al, 2011a,b,c,d;Carboni et al, 2010). The results are extremely complex, but in sum, differences were reported to be dependent upon both the genetic factor (strain differences) and to the environmental factor (maternal deprivation) (Carboni et al, 2010).…”

Section: Recent and Current Researchmentioning

confidence: 99%

The Flinders Sensitive Line Rat Model of Depression—25 Years and Still Producing

Overstreet

Wegener²

2013

Pharmacol Rev

201

146

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“…Several chronic conditions of affective/ emotional dysregulation, e.g., aging and depression, are associated with reductions in brain-derived neurotrophic factor (BDNF; Angelucci et al 2005;Martinowich et al 2007;Post 2010). In the Flinders Sensitive line of rats, early-life stress (maternal separation) produced significant reductions in IL-4, IL-6, IL-10, CRP, and BDNF (Carboni et al 2010). Contrastingly, the evidence for exerciseinduced BDNF from brain regions that contribute to the regulation of energy homeostasis and stress-affect is compelling (Borroni et al 2009;Pedersen et al 2009;Rasmussen et al 2009).…”

Section: Exercise and Affect-inflammation Statesmentioning

confidence: 99%

Influence of Physical Exercise on Neuroimmunological Functioning and Health: Aging and Stress

et al. 2010

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Chronic and acute stress, with associated pathophysiology, are implicated in a variety of disease states, with neuroimmunological dysregulation and inflammation as major hazards to health and functional sufficiency. Psychosocial stress and negative affect are linked to elevations in several inflammatory biomarkers. Immunosenescence, the deterioration of immune competence observed in the aged aspect of the life span, linked to a dramatic rise in morbidity and susceptibility to diseases with fatal outcomes, alters neuroimmunological function and is particularly marked in the neurodegenerative disorders, e.g., Parkinson's disease and diabetes. Physical exercise diminishes inflammation and elevates agents and factors involved in immunomodulatory function. Both the alleviatory effects of life-long physical activity upon multiple cancer forms and the palliative effects of physical activity for individuals afflicted by cancer offer advantages in health intervention. Chronic conditions of stress and affective dysregulation are associated with neuroimmunological insufficiency and inflammation, contributing to health risk and mortality. Physical exercise regimes have induced manifest anti-inflammatory benefits, mediated possibly by brain-derived neurotrophic factor. The epidemic proportions of metabolic disorders, obesity, and diabetes demand attention; several variants of exercise regimes have been found repeatedly to induce both prevention and improvement under both laboratory and clinical conditions. Physical exercise offers a unique non-pharmacologic intervention incorporating multiple activity regimes, e.g., endurance versus resistance exercise that may be adapted to conform to the particular demands of diagnosis, intervention and prognosis inherent to the staging of autoimmune disorders and related conditions.

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Early-life stress and antidepressants modulate peripheral biomarkers in a gene–environment rat model of depression

Cited by 85 publications

References 64 publications

Neurochemical and Behavioural Changes in Rat Models of Depression

Neurochemical and Behavioural Changes in Rat Models of Depression

The Flinders Sensitive Line Rat Model of Depression—25 Years and Still Producing

Influence of Physical Exercise on Neuroimmunological Functioning and Health: Aging and Stress

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