Early-life stress and the gut microbiome: A comprehensive population-based investigation

Mulder, Rosa H.; Kraaij, Robert; Schuurmans, Isabel K.; Frances-Cuesta, Carlos; Sanz, Yolanda; Medina-Gomez, Carolina; Duijts, Liesbeth; Rivadeneira, Fernando; Tiemeier, Henning; Jaddoe, Vincent W.V.; Felix, Janine F.; Cecil, Charlotte A.M.

doi:10.1016/j.bbi.2024.02.024

Cited by 2 publications

(1 citation statement)

References 100 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…23,24 In adiccion stress is related to socio-economic adversity -but not overall early life stressis associated with a less diverse microbiome in the general population. 25,26 The specific objective is to identify stress levels in individuals during the COVID-19 pandemic, Tumbes 2022. We found in a population of 197 individuals, 15.2% of individuals do not present stress, while 22% do not present chronic psychosomatic stress.…”

Section: Health Psychology Researchmentioning

confidence: 99%

DNA metabarcoding technology for the identification of the fecal microbiome in patients with chronic stress

Pérez Urruchi,

Ramírez Elizalde,

Zapata Cornejo

et al. 2024

Health Psychology Research

View full text Add to dashboard Cite

In the latest research, the concept of stress is associated with the deregulation of several biological systems sensitive to stress, such as the immune system, the microbiome, the endocrine system and neuroanatomical substrates. The objective of the research was to identify the fecal microbiome in patients diagnosed with chronic stress and in healthy patients through a metabarcoding analysis. The methodology used fecal samples collected from 20 patients with stress and 20 healthy patients. For the diagnosis of stress, psychological tools previously validated by external researchers were used. For metabarcoding analysis, metagenomic DNA extraction was performed from the fecal samples. Next Generation Illumina genetic sequencing targeting the 16S rDNA gene was then performed, followed by bioinformatic analysis using QUIME II software. The results, at the psychological test level, 20 people with chronic stress were diagnosed, on the other hand, at the metabarcoding level, specifically at the Gender level, the Asteroleplasma bacteria present only in the 20 healthy patients was molecularly identified. On the other hand, the bacteria Alistipes and Bifidobacterium were identified with greater predominance in the 20 patients with stress. Concluding, the bacteria Alistipes and Bifidobacterium are candidates as possible markers of the intestinal microbiome in patients with chronic stress, and the bacteria Asteroleplasma are candidates as a bacterial marker of the intestinal microbiome in healthy people. Finally, the identification of the microbiome in patients with stress opens a new path to understanding stress and its relationship to dysregulation with the microbiome.

show abstract

Section: Health Psychology Researchmentioning

confidence: 99%

DNA metabarcoding technology for the identification of the fecal microbiome in patients with chronic stress

Pérez Urruchi,

Ramírez Elizalde,

Zapata Cornejo

et al. 2024

Health Psychology Research

View full text Add to dashboard Cite

show abstract

A pathophysiologic framework for the overlap of disorders of gut-brain interaction and the role of the gut microbiome

Shah,

Lee,

Suzuki

et al. 2024

Gut Microbes

View full text Add to dashboard Cite

The International Rome Committee defines Disorders of Gut-Brain Interactions (DGBI) based upon distinct combinations of chronic and/or recurrent unexplained gastrointestinal symptoms. Yet patients often experience overlapping DGBI. Patients with DGBI frequently also suffer from extraintestinal symptoms, including fatigue, sleep disturbances, anxiety, and depression. Patients with overlapping DGBI typically experience more severe GI symptoms and increased psychosocial burden. Concerning the pathophysiology, DGBI are associated with disruptions in gut motility, function of the brain and enteric neurons, immune function, and genetic markers, with recent findings revealing gut microbiome alterations linked to these mechanisms of DGBI. Emerging evidence summarized in this review suggests that the microbiome influences various established disease mechanisms of different DGBI groups. Overall, changes in the gastrointestinal microbiome do not seem to be linked to a specific DGBI subgroup but may play a key role in the manifestation of different DGBI and, subsequently, overlap of DGBI. Understanding these shared mechanisms and the role of the gastrointestinal microbiome, particularly for overlapping DGBI, might aid in developing more precise diagnostic criteria and treatment strategies while developing personalized interventions that target specific mechanisms to improve patient outcomes.

show abstract

Early-life stress and the gut microbiome: A comprehensive population-based investigation

Cited by 2 publications

References 100 publications

DNA metabarcoding technology for the identification of the fecal microbiome in patients with chronic stress

DNA metabarcoding technology for the identification of the fecal microbiome in patients with chronic stress

A pathophysiologic framework for the overlap of disorders of gut-brain interaction and the role of the gut microbiome

Contact Info

Product

Resources

About