2021
DOI: 10.1016/j.neuropharm.2020.108416
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Early-life stress exacerbates the effects of WIN55,212-2 and modulates the cannabinoid receptor type 1 expression

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Cited by 14 publications
(17 citation statements)
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“…Furthermore, in healthy humans, changes in eCB plasma levels in response to acute stress were larger in men than in women (Dlugos et al, 2012). Behavioural effects of exogenous cannabinoids may be more or less pronounced dependent on such differences in the eCB system (Martín-Sanchez et al, 2021).…”
Section: Discussionmentioning
confidence: 99%
“…Furthermore, in healthy humans, changes in eCB plasma levels in response to acute stress were larger in men than in women (Dlugos et al, 2012). Behavioural effects of exogenous cannabinoids may be more or less pronounced dependent on such differences in the eCB system (Martín-Sanchez et al, 2021).…”
Section: Discussionmentioning
confidence: 99%
“…We have previously reported that MSEW protocol causes persistent detrimental consequences in offspring development, inducing behavioural and neurobiological alterations 27,28,38 , that also might occur in children whose mother who has experienced PPD 39,40 . Altogether, these findings highlight the importance of a mother-infant relationship for a healthy development of both parts.…”
Section: Discussionmentioning
confidence: 99%
“…Litters of 6 pups were selected. Dams were randomly assigned to one of two rearing conditions: standard nest (SN) and maternal separation with early weaning (MSEW), which was conducted as previously 27,28 . Briefly, MSEW litters were separated from their mothers for 4 h daily between PD 2-5 (09:30–13:30 h) and 8 h daily between PD6-16 (09:30–17:30 h), and then, they were weaned early on PD 17.…”
Section: Methodsmentioning
confidence: 99%
“…In our laboratory, we use a well-established mouse model of early-life stress known as maternal separation with early weaning (MSEW), (George et al, 2010), which recapitulates the main phenotype observed in depression, such as anhedonia (Gracia-Rubio et al, 2016), social interaction disruption (Portero-Tresserra et al, 2018), despairlike behaviour (Gracia-Rubio et al, 2016) and anxiety-like behaviours (Martín-Sánchez et al, 2021). Moreover, animals exposed to MSEW exhibit a higher vulnerability to drug consumption Portero-Tresserra et al, 2018) as well as alterations in glutamatergic , serotonergic (Gracia-Rubio et al, 2016) and endocannabinoid systems (Martín-Sánchez et al, 2021;Portero-Tresserra et al, 2018).…”
Section: Introductionmentioning
confidence: 99%
“…In our laboratory, we use a well-established mouse model of early-life stress known as maternal separation with early weaning (MSEW), (George et al, 2010), which recapitulates the main phenotype observed in depression, such as anhedonia (Gracia-Rubio et al, 2016), social interaction disruption (Portero-Tresserra et al, 2018), despairlike behaviour (Gracia-Rubio et al, 2016) and anxiety-like behaviours (Martín-Sánchez et al, 2021). Moreover, animals exposed to MSEW exhibit a higher vulnerability to drug consumption Portero-Tresserra et al, 2018) as well as alterations in glutamatergic , serotonergic (Gracia-Rubio et al, 2016) and endocannabinoid systems (Martín-Sánchez et al, 2021;Portero-Tresserra et al, 2018). Despite the fact that we observed a sexual dimorphism in several outcomes related to MSEW, depressive-like behaviour and cocaine seeking in the present model (Castro-Zavala et al, 2021), there are no previous reports studying possible brain metabolic capacity alterations in MSEW females, since most of the studies have been developed only in male mice.…”
Section: Introductionmentioning
confidence: 99%