Early lung cancer with lepidic pattern

Weichert, Wilko; Warth, Arne

doi:10.1097/mcp.0000000000000065

Cited by 56 publications

(15 citation statements)

References 63 publications

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“…The mean age of the patients was 65.1± 7.5 years, 93.3% self-reported race as white, 55.2% were female, 90.5% were ever-smokers, and 47% had stage I lung cancer. According to their growth pattern, we classified tumors into two subtypes as previous studies 12-14 : (1) lepidic predominant adenocarcinomas (n=55), and (2) adenocarcinomas without a predominant lepidic growth (n=62), among these cases, 11 had a small proportion of a lepidic component. Lepidic growth pattern was defined as involving alveolar septa with a relative lack of acinar filling.…”

Section: Methodsmentioning

confidence: 99%

Semiquantitative Computed Tomography Characteristics for Lung Adenocarcinoma and Their Association With Lung Cancer Survival

Wang

Schabath

Liu

et al. 2015

Clinical Lung Cancer

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Background Computed tomographic (CT) characteristics derived from noninvasive images that represent the entire tumor may have diagnostic and prognostic value. The purpose of this study was to assess the association of a standardized set of semiquantitative CT characteristics of lung adenocarcinoma with overall survival. Patients and Methods An initial set of CT descriptors was developed to semiquantitatively assess lung adenocarcinoma in patients (n=117) who underwent resection. Survival analyses were used to determine the association between each characteristic and overall survival. Principle component analysis (PCA) was used to determine characteristics that may differentiate histological subtypes. Results Characteristics significantly associated with overall survival included pleural attachment (p < 0.001), air bronchogram (p = 0.03), and lymphadenopathy (p = 0.02). Multivariate analyses revealed pleural attachment was significantly associated with an increased risk of death overall (hazard ratio [HR] = 3.21; 95% confidence interval [CI] 1.53 – 6.70) and among patients with lepidic predominant adenocarcinomas (HR = 5.85; 95% CI 1.75 – 19.59), while lymphadenopathy was significantly associated with an increased risk of death among patients with adenocarcinomas without a predominant lepidic component (HR = 3.07; 95% CI 1.09 – 8.70). A PCA model showed that texture (ground-glass opacity component) was most important for separating the two subtypes. Conclusion A subset of the semiquantitative characteristics described herein has prognostic importance and ability to distinguish between different histological subtypes of lung adenocarcinoma.

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Section: Methodsmentioning

confidence: 99%

Semiquantitative Computed Tomography Characteristics for Lung Adenocarcinoma and Their Association With Lung Cancer Survival

Wang

Schabath

Liu

et al. 2015

Clinical Lung Cancer

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“…The progression of GGNs from AAH, AIS and MIA to IAC is a continuous and dynamic process accompanied by the increment of malignancy [10]. The intraoperative classification of early lung adenocarcinoma is of great significance in determining surgical strategy [11].…”

Section: Introductionmentioning

confidence: 99%

Joint use of the radiomics method and frozen sections should be considered in the prediction of the final classification of peripheral lung adenocarcinoma manifesting as ground-glass nodules

Wang

Tang

Chen³

et al. 2020

Lung Cancer

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“…The histological subtyping of ADC has a high prognostic (Warth et al , 2012) and predictive relevance (Tsao et al , 2015), with a gradual downgrading from lepidic (good prognosis) over acinar and papillary (moderate) to solid and micropapillary (poor). Thus, the histological patterns can be related to different stages of tumour progression (Weichert and Warth, 2014). Taking this into consideration, the observed correlation between histological growth patterns and mtDNA levels might be a stepwise reduction of mtDNA-CN during ADC evolution.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of somatic mitochondrial mutations and spatial distribution of mitochondria in non-small cell lung cancer

et al. 2017

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Background:Mitochondria are considered relevant players in many tumour entities and first data indicate beneficial effects of mitochondria-targeted antioxidants in both cancer prevention and anticancer therapies. To further dissect the potential roles of mitochondria in NSCLC we comprehensively analysed somatic mitochondrial mutations, determined the spatial distribution of mitochondrial DNA within complete tumour sections and investigated the mitochondrial load in a large-scale approach.Methods:Whole mitochondrial genome sequencing of 26 matched tumour and non-neoplastic tissue samples extended by reviewing published data of 326 cases. Systematical stepwise real-time PCR quantification of mitochondrial DNA covering 16 whole surgical tumour sections. Immunohistochemical determination of the mitochondrial load in 171 adenocarcinoma and 145 squamous cell carcinoma.Results:Our results demonstrate very low recurrences (max. 1.7%) and a broad distribution of 456 different somatic mitochondrial mutations. Large inter- and intra-tumour heterogeneity were seen for mitochondrial DNA copy numbers in conjunction with a correlation to the predominant histological growth pattern. Furthermore, tumour cells had significantly higher mitochondrial level compared to adjacent stroma, whereas differences between tumour entities were negligible.Conclusions:Non-evident somatic mitochondrial mutations and highly varying mitochondrial DNA level delineate challenges for the approach of mitochondria-targeted anticancer therapies in NSCLC.

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Early lung cancer with lepidic pattern

Abstract: The validity and clinical importance of the novel concept of ADC precursor lesions and LPA have been confirmed by clinical, radiological, morphological, and molecular data. Thereby, it has evolved into a valuable tool to aid in clinical decision-making.

Cited by 56 publications

References 63 publications

Semiquantitative Computed Tomography Characteristics for Lung Adenocarcinoma and Their Association With Lung Cancer Survival

Semiquantitative Computed Tomography Characteristics for Lung Adenocarcinoma and Their Association With Lung Cancer Survival

Joint use of the radiomics method and frozen sections should be considered in the prediction of the final classification of peripheral lung adenocarcinoma manifesting as ground-glass nodules

Prevalence of somatic mitochondrial mutations and spatial distribution of mitochondria in non-small cell lung cancer

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