Early medical abortion with methotrexate and misoprostol

Borgatta, Lynn; Burnhill, Michael S.; Tyson, Judith; Leonhardt, Kathryn Kraft; Hausknecht, Richard; Haskell, Sue

doi:10.1016/s0029-7844(00)01090-5

Cited by 20 publications

(8 citation statements)

References 11 publications

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“…When 50 mg/m 2 of intramuscular methotrexate was followed by 800 mcg of vaginal misoprostol 3 to 7 days later in women with a pregnancy duration of 49 days or less, the day of misoprostol administration, was not found to have an effect on outcome [23,27,42–44].…”

Section: Clinical Outcomes Of Alternative Methodsmentioning

confidence: 91%

“…In women with a pregnancy duration less than 49 days, the reported success rate after administration of 50/m 2 mg of oral methotrexate followed by 800 mcg of vaginal misoprostol was between 90% and 91% [26,43]. When 50 mg/m 2 of intramuscular methotrexate was followed by 800 mcg of vaginal misoprostol in women with a pregnancy duration less than 49 days, however, the observed success ranged between 75% and 95% [23,27,42,44].…”

Section: Clinical Outcomes Of Alternative Methodsmentioning

confidence: 97%

“…It has been used in single or short‐term administration as an alternative treatment for ectopic pregnancy and for first‐trimester medical abortion [1,24]. Used in a single dose, the adverse effects of methotrexate include nausea, vomiting, headaches, and mouth sores [25–28]. Complications are rare and thrombocytopenia is an unusual event [27,29].…”

Section: Alternative Medical Abortion Agents To Mifepristonementioning

confidence: 99%

“…Used in a single dose, the adverse effects of methotrexate include nausea, vomiting, headaches, and mouth sores [25–28]. Complications are rare and thrombocytopenia is an unusual event [27,29]. Methotrexate is contraindicated in women with cytopenia, thrombocytopenia, immune or hematopoetic suppression, or renal or hepatic impairment.…”

Section: Alternative Medical Abortion Agents To Mifepristonementioning

confidence: 99%

See 3 more Smart Citations

Alternatives to mifepristone for early medical abortion

Moreno-Ruiz

Borgatta

Yanow

et al. 2007

International Journal of Gynecology & Obstetrics

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Section: Clinical Outcomes Of Alternative Methodsmentioning

confidence: 91%

Section: Clinical Outcomes Of Alternative Methodsmentioning

confidence: 97%

Section: Alternative Medical Abortion Agents To Mifepristonementioning

confidence: 99%

Section: Alternative Medical Abortion Agents To Mifepristonementioning

confidence: 99%

See 2 more Smart Citations

Alternatives to mifepristone for early medical abortion

Moreno-Ruiz

Borgatta

Yanow

et al. 2007

International Journal of Gynecology & Obstetrics

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show abstract

“…At the end of 0.5 h and 1 h, the tablet was withdrawn, dried with tissue paper and weighed. Then for every 1 h, weight of the tablet was noted and the process was continued till the end of 8 h percentage gain by the tablet was calculated by formula:[32]…”

Section: Methodsmentioning

confidence: 99%

Isolation, characterization, and evaluation of Cassia fistula Linn. seed and pulp polymer for pharmaceutical application

Killedar

Nale

et al. 2014

Int J Pharma Investig

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Introduction:Present work, is an effort toward exploring the potential of Cassia fistula Linn. seed gum as an extended release polymer and laxative. While, C. fistula pulp polymer has evaluated as suspending agent.Materials and Methods:For extended release application, total five batches (F1-F5) were prepared by varying the ratio of drug:polymer as 1:1, 1:2, 1:3, 1:4, and 1:5, respectively. The granules were prepared by wet granulation method and further evaluated for micromeritic properties such as angle of repose (θ), Carr's compressibility index (CCI), and Hausner's ratio. Further compacts were evaluated by hardness, thickness, swelling index, in-vitro dissolution, and so on. Laxative activity was evaluated by administration of seed polymer (100 mg/kg) alone or in combination with bisacodyl (2.5 mg/kg) in 1% Tween 80. Zinc oxide suspension was prepared by varying the concentration of C. fistula pulp polymer and compared with suspension made by use of tragacanth, sodium carboxymethyl cellulose and bentonite.Results:Result showed that granules were free flowing, while the compact extended the drug release up to 10 h (72.84 ± 0.98; batch F5) and followed Higuchi matrix release kinetics. This extended release might be due to the formation of polyelectrolyte complex because of gluco-mannose in seed gum. Result of in-vivo laxative activity showed that seed polymer reduced faeces weight after 24 h compared to control (P < 0.01).Conclusions:Pulp polymer showed good sedimentation volume, but alone fails to stabilize the suspension for a longer period, so it could be useful in combination with other suspending agents and can be useful as novel excipient.

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Medical Abortion in Early Pregnancy

Creinin

Danielsson

2009

Management of Unintended and Abnormal Pregnancy

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The standard or classic regimen of mifepristone 600 mg followed 36 to 48 hours later by a prostaglandin analog, typically misoprostol 400 µg orally, is highly effective for abortion up to 49 days' gestation.r Mifepristone can be used at a dose of 200 mg, instead of 600 mg, with equal efficacy and lower cost. r When the misoprostol is used vaginally, the gestational age limit can be extended to 63 days and the medications can be administered as little as 6 to 8 hours apart or even simultaneously.r Buccal and sublingual misoprostol also are effective when used at 24-to 48-hour intervals after mifepristone. These alternative routes appear to have more side effects than vaginal administration.r Ultrasound examination 1 week after administering the medications is highly predictive of long-term success of the medical abortion procedure.r Methotrexate and misoprostol can be used as an alternative regimen in women up to 49 days' gestation. The methotrexate does not appear to have immediate effect in the abortion process; rather, by rendering the pregnancy nonviable, methotrexate may serve as a backup for women who do not abort shortly after misoprostol administration.r Misoprostol alone, in repeated doses, can be used for abortion where mifepristone is too expensive or unavailable. The recommended regimen for pregnancies up to 63 days' gestation is 800 µg administered vaginally every 3 to 24 hours for a maximum of three doses.

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Early medical abortion with methotrexate and misoprostol

Abstract: Medical abortion with methotrexate and misoprostol is safe and effective and can be offered in a community setting.

Cited by 20 publications

References 11 publications

Alternatives to mifepristone for early medical abortion

Alternatives to mifepristone for early medical abortion

Isolation, characterization, and evaluation of Cassia fistula Linn. seed and pulp polymer for pharmaceutical application

Medical Abortion in Early Pregnancy

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