Early metabolic changes in the gut leads to higher expression of intestinal alpha glucosidase and thereby causes enhanced postprandial spikes

Nalawade, Megha L.; Patil, Rahul; Bavkar, Laxman N.; Rooge, Sheetalnath; Haldavnekar, Vivek S.; Arvindekar, Akalpita U.

doi:10.1016/j.lfs.2018.12.025

Cited by 7 publications

(4 citation statements)

References 23 publications

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“…than in the suckling group. MGAM and SI play important roles in the final digestion of starch ( Calvo et al, 2000 ; Ghadyale et al, 2012 ; Nalawade et al, 2019 ), PYGM and G6PC2 are key glycogenolytic enzymes ( Al-Daghri et al, 2017 ; Migocka-Patrzałek et al, 2020 ). Similarly, key genes involved in starch and sucrose metabolism are found highly expressed in the livers of adult groups of herbivore macaques ( GCK , PGM2 , etc.)…”

Section: Discussionmentioning

confidence: 99%

Comparative study of the digestion and metabolism related genes’ expression changes during the postnatal food change in different dietary mammals

Yizhen,

Chen,

Jie

et al. 2023

Front. Genet.

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The changes in the expression of genes related to digestion and metabolism may be various in different dietary mammals from juvenile to adult, especially, the giant panda (Ailuropoda melanoleuca) and red panda (Ailurus fulgens), which were once carnivores but have shifted to being specialized bamboo eaters, are unique features of their changes are more unclear. To elucidate the changing patterns of gene expression related to digestion and metabolism from juvenile to adult in different dietary mammals, we performed transcriptome analysis of the liver or pancreas in giant and red pandas, herbivorous rabbits (Oryctolagus cuniculus) and macaques (Macaca mulatta), carnivorous ferrets (Mustela putorius furo), and omnivorous mice (Mus musculus) from juvenile to adult. During the transition from juvenile to adulthood, giant and red pandas, as well as rabbits and macaques, show significant upregulation of key genes for carbohydrate metabolism, such as starch hydrolysis and sucrose metabolism, and unsaturated fatty acid metabolism, such as linoleic acid, while there is no significant difference in the expression of key genes for fatty acid β-oxidation. A large number of amino acid metabolism related genes were upregulated in adult rabbits and macaques compared to juveniles. While adult giant and red pandas mainly showed upregulation of key genes for arginine synthesis and downregulation of key genes for arginine and lysine degradation. In adult stages, mouse had significantly higher expression patterns in key genes for starch hydrolysis and sucrose metabolism, as well as lipid and protein metabolism. In contrast to general expectations, genes related to lipid, amino acid and protein metabolism were significantly higher expressed in adult group of ferrets, which may be related to their high metabolic levels. Our study elucidates the pattern of changes in the expression of genes related to digestion and metabolism from juvenile to adult in different dietary mammals, with giant and red pandas showing adaptations associated with specific nutritional limitations of bamboo.

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Section: Discussionmentioning

confidence: 99%

Comparative study of the digestion and metabolism related genes’ expression changes during the postnatal food change in different dietary mammals

Yizhen,

Chen,

Jie

et al. 2023

Front. Genet.

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“…Alcoholic fermentation is the process of conversion of monosugars, especially glucose, and fructose, in CAJ to ethanol. Fructose has been reported to possess inherent α-glucosidase inhibitory activity [62]. Furthermore, the varying inhibitory activities among the fermented samples suggest the potential contribution of other factors such as phenolic compounds, which are known α-glucosidase inhibitors [63], in the presence of L. pentosus, which has inherent inhibitory activity towards the enzyme α-glucosidase [64].…”

Section: Comparison Of Fermented Caj Product Properties Using Differe...mentioning

confidence: 99%

Valorization of Cashew Apple Waste into a Low-Alcohol, Healthy Drink Using a Co-Culture of Cyberlindnera rhodanensis DK and Lactobacillus pentosus A14-6

Kham,

Phovisay,

Unban

et al. 2024

Foods

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This study investigated the potential of microbial fermentative transforming processes in valorizing the cashew apple by-product into a low-alcohol, health-benefiting beverage. We particularly investigated the use of a non-Saccharomyces yeast, Cyberlindnera rhodanensis DK, as the main targeted microbe. At 30 °C without agitation, C. rhodanensis DK caused changes in key parameters during the fermentation of cashew apple juice (CAJ) in terms of varied pH values and initial sugar concentrations. This result indicated that pure CAJ, with pH adjusted to 6 and with the original 6.85% (w/v) total sugar content, was the most feasible condition, as glucose and fructose were mostly consumed at 12 days of fermentation. A co-culture approach with either Saccharomyces cerevisiae TISTR 5088 or Lactobacillus pentosus A14-6 was investigated to improve both physicochemical and fermentation characteristics. Co-fermentation with S. cerevisiae TISTR 5088 resulted in significantly increased ethanol accumulation to 33.61 ± 0.11 g/L, but diminished bioactive compounds, antioxidant activity, and antidiabetic potential. In contrast, co-fermentation with L. pentosus A14-6 demonstrated excellent outcomes, as it significantly increased sugar consumption and finally remained at only 4.95 g/L compared to C. rhodanensis DK alone, produced lower levels of ethanol at only 19.47 ± 0.06 g/L, and higher total titratable acid (TTA), resulting in a final pH of 3.6. In addition, co-fermentation with this lactic acid bacterium significantly enhanced bioactive compounds and antioxidant activity and also retained potential antidiabetic properties. These findings highlight the feasibility of using tailored microbial fermentation strategies to produce low-alcohol beverages with enhanced health-promoting properties from CAJ; however, product-development processes following health food regulations and sensory evaluation are necessary.

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“…At the same time, it is also shown to have an irreparable impact and can cause progressive, cumulative dysfunction at the cellular and molecular levels. Hence, a diet overloaded with carbohydrates, saturated fats, and poor nutritional value is a vital factor in the risk of developing these disorders/diseases 27–30 . Consumption of a high carbohydrate diet is a primary and active risk factor for the etiology of AD; 21 elaboratively, it dysfunctions the glucose transporters along with amyloid‐β precursor protein (APP) by disturbing lipid metabolism within the central nervous system (CNS) and by overproducing insulin and excess Insulin‐like growth factor signaling for a long time, ultimately damages the neurons 31 .…”

Section: Pathological Mechanisms Linking Diabetes Mellitus Ad and Pdmentioning

confidence: 99%

“…Hence, a diet overloaded with carbohydrates, saturated fats, and poor nutritional value is a vital factor in the risk of developing these disorders/diseases. [27][28][29][30] Consumption of a high carbohydrate diet is a primary and active risk factor for the etiology of AD; 21 elaboratively, it dysfunctions the glucose transporters along with amyloid-β precursor protein (APP) by disturbing lipid metabolism within the central nervous system (CNS) and by overproducing insulin and excess Insulin-like growth factor signaling for a long time, ultimately damages the neurons. 31 In 2017, Kandimalla et al 32 marked that persons with type 3 diabetes and persons with AD share a correlation between metabolic changes and carbohydrates, lipids, proteins, and brain dysfunction as standard mechanistic links.…”

Section: Diet Lifestyle and Epigeneticsmentioning

confidence: 99%

Communal interaction of glycation and gut microbes in diabetes mellitus, Alzheimer's disease, and Parkinson's disease pathogenesis

Patil,

Tupe

2023

Medicinal Research Reviews

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Diabetes and its complications, Alzheimer's disease (AD), and Parkinson's disease (PD) are increasing gradually, reflecting a global threat vis‐à‐vis expressing the essentiality of a substantial paradigm shift in research and remedial actions. Protein glycation is influenced by several factors, like time, temperature, pH, metal ions, and the half‐life of the protein. Surprisingly, most proteins associated with metabolic and neurodegenerative disorders are generally long‐lived and hence susceptible to glycation. Remarkably, proteins linked with diabetes, AD, and PD share this characteristic. This modulates protein's structure, aggregation tendency, and toxicity, highlighting renovated attention. Gut microbes and microbial metabolites marked their importance in human health and diseases. Though many scientific shreds of evidence are proposed for possible change and dysbiosis in gut flora in these diseases, very little is known about the mechanisms. Screening and unfolding their functionality in metabolic and neurodegenerative disorders is essential in hunting the gut treasure. Therefore, it is imperative to evaluate the role of glycation as a common link in diabetes and neurodegenerative diseases, which helps to clarify if modulation of nonenzymatic glycation may act as a beneficial therapeutic strategy and gut microbes/metabolites may answer some of the crucial questions. This review briefly emphasizes the common functional attributes of glycation and gut microbes, the possible linkages, and discusses current treatment options and therapeutic challenges.

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Early metabolic changes in the gut leads to higher expression of intestinal alpha glucosidase and thereby causes enhanced postprandial spikes

Cited by 7 publications

References 23 publications

Comparative study of the digestion and metabolism related genes’ expression changes during the postnatal food change in different dietary mammals

Comparative study of the digestion and metabolism related genes’ expression changes during the postnatal food change in different dietary mammals

Valorization of Cashew Apple Waste into a Low-Alcohol, Healthy Drink Using a Co-Culture of Cyberlindnera rhodanensis DK and Lactobacillus pentosus A14-6

Communal interaction of glycation and gut microbes in diabetes mellitus, Alzheimer's disease, and Parkinson's disease pathogenesis

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