In early 2020, hospitals across the US, including Children's Hospital Colorado (CHCO), began preparing for the regional impact of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic via an Incident Command Team (ICT), a unified approach to hospital operations including the command, control, and coordination of incident management. [1][2][3] The ICT at CHCO recognized the need for a scientific partnership for rapid uptake and synthesis of quickly accruing medical and public health literature to inform institutional policies and clinical care. Therefore, the ICT established a coronavirus disease 2019 (COVID-19) Scientific Advisory Council (SAC), 4 a multidisciplinary team of clinicianscientists from relevant CHCO clinical divisions and CHCO's Clinical Effectiveness (CE) team members. 5 The SAC leadership developed an academic-hospital partnership and set of processes for identification of issues, priority-setting, rapid evidence assessment, as well as synthesis and dissemination of findings. To support other organization's efforts to create a similar academic-operational partnership, this paper describes the SAC's innovative infrastructure: the diverse team and the processes the SAC developed for rapid evidence synthesis, development of recommendations and guideline documents, and dissemination of findings: the Children's Colorado Rapid Evidence Analysis and Dissemination System (CCREADS).