Early nasojejunal feeding in acute pancreatitis is associated with a lower complication rate

Oláah, Attila; Pardavi, G; Beláagyi, Tibor; Nagy, Ágoston; Issekutz, Akos; Mohamed, Gihan Samir

doi:10.1016/s0899-9007(01)00755-9

Cited by 172 publications

(116 citation statements)

References 21 publications

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“…It was also reported that gram-negative organisms, anaerobes and fungi were isolated from the pancreatic necrosis (Beger et al, 1986(Beger et al, , 1997. Experimental studies of bacterial translocation have also shown that bacterial translocation occured in 40-70% of necrotizing pancreatitis (Oláh et al, 2002b). These findings suggested that the source of infection was the intestine in necrotizing pancreatitis.…”

Section: Discussionmentioning

confidence: 91%

“…The importance of enteral nutrition was accepted by several authors in recent years. It is shown that the nutrition by enteral route is better utilized compared by parenteral route in many studies (Oláh et al, 2002b). The main advantages of enteral feeding are to stop the progression of gastrointestinal mucosal atrophy and to help maintaining of immune status and normal gut flora (Nakasaki et al, 1988).…”

Section: Discussionmentioning

confidence: 99%

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Effects of probiotics on the severity of experimental acute pancreatitis

et al. 2005

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Objective: This study was designed to evaluate the effects of probiotics on the severity of experimental acute pancreatitis. Design: Experimental study. Setting: Experiments were done in a laboratory at Haydarpasa Numune Teaching and Research Hospital. Subjects:A total of 50 Wistar rats were randomly divided into five groups. Interventions: Group 1 was control group. Group 2 received an intraperitoneal injection of a 20% solution in 0.15 mol/l NaCL. Group 3 was injected NaCL and fed with probiotics. Acute pancreatitis was induced in rats by intrperitoneal injection of L-Arginine in groups 4 and 5. The rats in group 5 were treated with probiotics. The pancreas was removed for histologic examination. Evaluation of the pathologic changes was done by a new combined histopathologic grading scale. Results: The mean scores of fibrosis, acinar cell loss, oedema, parenchymal necrosis, mononuclear cells infiltration, polymorphonuclear leucocytes infiltration, ductal damage and atypical reactive regeneration in group 5 were significantly lower than group 4. Conclusions: We demonstrated that enteral feedings with added probiotics can reduce the severity of acute pancreatitis. Sponsorship: None.

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Effects of probiotics on the severity of experimental acute pancreatitis

et al. 2005

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“…That means to keep the pancreas in rest and rehabilitation for a long time. However, these effects are not so pronounced when nutrients are delivered directly into the jejunum [11][12][13][14][15][16][17][18] . Heidenhain in 1 875 first demonstrated the effect of vagal and entero-hormone stimulation on pancreatic secretion, in which hormones played a more important role than vagal stimulation.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, many surgeons hold scrupulously that the EIN may exacerbate the clinical pathological features, and lead to recurrence of symptoms and delayed complications to be cured [11][12][13][14][15][16][17][18] . However, these problems could be overcome if enteral nutrition is delivered to the distal ileum far away from the Treitz's ligament, to avoid stimulation of the cephalic and gastric phase, and those effects are not so pronounced as nutrients are delivered directly into jejunum [3,[9][10][11][12][13] . Therefore, it is necessary to investigate the efficiency of early intrajejunal nutrition on pancreatitic clinicopathological changes, entero-hormone release and its efficacy on dogs with acute pancreatitis.…”

Section: Introductionmentioning

confidence: 99%

Parenteral versus early intrajejunal nutrition: Effect on pancreatitic natural course, entero-hormones release and its efficacy on dogs with acute pancreatitis

Qin

Su²,

Hu³

et al. 2003

WJG

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AIM:To evaluate the effect of early intrajejunal nutrition (EIN) on the natural course, entero-hormone secretion and its efficacy on dogs with acute pancreatitis. METHODS:An acute pancreatitis model was induced by injecting 1 ml/kg of combined solution (2.5 % sodium taurocholate and 8 000-10 000 BAEE units trypsin/ml) into the pancreas via pancreatic duct. Fifteen dogs were divided into parenteral nutrition (PN) group and EIN group. Two groups were isonitrogenous and isocaloric. EIN was used at postoperative 24 h. Serum glucose, calcium, amylase and lysosomal enzymes were determined before and 1, 4, 7 d after acute pancreatitis was induced. All the dogs were injected 50 uCi RESULTS:There was no difference between two groups in the contents of serum calcium, amylase and lysosomal enzymes, 125 I-BSA index of pancreas/muscle and pancreas/ blood and PPS. The contents of CCK and gastrin in EIN were higher than those in PN group at 60 and 120 min (P<0.05). The content of SEC post-infusion of nutrition solution was higher than that of pre-infusion of nutrition solution in both groups, and only at 60 min SEC in EIN group was higher than that in PN group. The content of gastrin in EIN was higher than that in PN group at 120 and 180 min (P<0.05). CONCLUSION: EIN does not stimulate entero-hormone and pancreatic juice secretion, and enzyme-protein synthesis and release. EIN has no effect on the natural course of acute pancreatitis.Qin HL, Su ZD, Hu LG, Ding ZX, Lin QT. Parenteral versus early intrajejunal nutrition: Effect on pancreatitic natural course, entero-hormones release and its efficacy on dogs with acute pancreatitis.

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“…[1][2][3][4] There are multiple techniques for placing jejunal feeding tubes, including surgical jejunostomy, direct percutaneous enterojejunostomy, passing a jejunal extension through a PEG (PEG-J), and nasojejunal (NJ) placement. Inadvertent withdrawal of the tube during scope removal and other complications during the placement of a jejunal feeding tube can lead to a frustrating experience for the endoscopist.…”

mentioning

confidence: 99%