Early Objective Diagnosis and Staging of Acute Pancreatitis by Contrast-Enhanced Computed Tomography

Maier, W

doi:10.1007/978-3-642-83027-3_18

Cited by 21 publications

(3 citation statements)

References 12 publications

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“…In a previous study, people with CT evidence of pancreatic necrosis (ie, heterogeneous contrast enhancement) had a 23% mortality rate and 82% morbidity rate compared to 0% mortality rate and 6% morbidity in the absence of necrosis (ie, homogeneous pancreatic contrast enhancement) . In addition, CTA has shown overall accuracy of 87% and sensitivity of 100% in diagnosing surgically confirmed pancreatic necrosis in humans . The CTA findings are utilized to determine the course of treatment in human patients diagnosed with acute pancreatitis …”

Section: Introductionmentioning

confidence: 99%

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Computed tomographic angiography and ultrasonography in the diagnosis and evaluation of acute pancreatitis in dogs

French

Twedt

Rao

et al. 2018

Veterinary Internal Medicne

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BackgroundAcute pancreatitis in dogs is an under‐diagnosed disease. Current diagnostic methods are insufficient at identifying sequelae and lack prognostic capability. Computed tomographic angiography (CTA) is accurate for diagnosis and prognostication of pancreatitis in humans.ObjectivesIn comparison to ultrasound (US), CTA will (1) better diagnose more severe pancreatitis and sequelae and (2) provide assessment of patient outcome by identification of pancreatic contrast enhancement patterns.AnimalsTwenty‐six client‐owned dogs suspected to have acute pancreatitis.MethodsUS and CTA examinations performed at time of admission were compared to determine the detection of pancreatic changes and sequelae. CTA findings also were compared to outcome indicators for prognosis of dogs with acute pancreatitis. Specific canine pancreatic lipase (cPL) samples were obtained and compared with CTA findings.ResultsTen of 26 dogs had heterogeneous contrast enhancement of the pancreas. Compared to US, CTA better identified portal vein thrombosis (P = .003). Patients with heterogeneous contrast enhancement had longer hospitalization (P = .01), including hospital stays for >5 days (P = .02), had more relapses, and were more likely to have portal vein thrombosis (P = .002). Patients with heterogeneous contrast enhancement had increased spec cPL (P = .006).Conclusions and Clinical ImportanceIn comparison to US, CTA better identified dogs with more severe acute pancreatitis and those with portal vein thrombosis, factors that may predict longer hospitalization and increased risk of relapse. The presence of heterogeneous contrast enhancement and portal vein thrombosis may change therapy for patients with acute pancreatitis.

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Section: Introductionmentioning

confidence: 99%

“…In addition, CTA has shown overall accuracy of 87% and sensitivity of 100% in diagnosing surgically confirmed pancreatic necrosis in humans . The CTA findings are utilized to determine the course of treatment in human patients diagnosed with acute pancreatitis …”

Section: Introductionmentioning

confidence: 99%

Computed tomographic angiography and ultrasonography in the diagnosis and evaluation of acute pancreatitis in dogs

French

Twedt

Rao

et al. 2018

Veterinary Internal Medicne

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“…Necrosis can be detected by CECT as a focal or diffuse area of diminished pancreatic parenchymal contrast enhancement 79,81,84,85 Table 10).…”

Section: Introductionmentioning

confidence: 99%

Guidelines for the management of acute pancreatitis

Toouli

Brooke-Smith

Bassi

et al. 2002

J of Gastro and Hepatol

366

252

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A Clinically Based Classification System for Acute Pancreatitis

1993

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Acute pancreatitis is a protean disease capable of wide clinical variation, ranging from mild discomfort to apocalyptic prostration. Moreover, the inflammatory process may remain localized in the pancreas, spread to regional tissues, or even involve remote organ systems. This variability in presentation and clinical course has plagued the study and management of acute pancreatitis since its original clinical description. In the absence of accepted definitions for acute pancreatitis and its complications, it has not been possible to devise a clinical classification system useful for case management. Following 3 days of group meetings and open discussions, unanimous consensus on a series of definitions and a clinically based classification system for acute pancreatitis was achieved by a diverse group of 40 international authorities from six medical disciplines and 15 countries. The proposed classification system will be of value to practicing clinicians in the care of individual patients and to academicians seeking to compare interinstitutional data.

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Early Objective Diagnosis and Staging of Acute Pancreatitis by Contrast-Enhanced Computed Tomography

Cited by 21 publications

References 12 publications

Computed tomographic angiography and ultrasonography in the diagnosis and evaluation of acute pancreatitis in dogs

Computed tomographic angiography and ultrasonography in the diagnosis and evaluation of acute pancreatitis in dogs

Guidelines for the management of acute pancreatitis

A Clinically Based Classification System for Acute Pancreatitis

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