Early-onset androgenetic alopecia in China: a descriptive study of a large outpatient cohort

Abstract

Objective: To describe the clinical features of early-onset androgenetic alopecia (AGA) in a large cohort of Chinese patients. Methods: This descriptive study recruited consecutive patients seeking medical treatment for AGA between 1 January 2013 and 30 November 2018. Patients were included in the study if they reported being 35 years old at AGA onset and if their pattern of hair loss was documented with photographs. The age of onset, sex, body mass index (BMI), BAsic and SPecific classification of hair loss and family history of alopecia were collected in an electronic database. Results: A total of 3897 patients with early-onset AGA were recruited to the study. The majority of patients (70.6%; 2751 of 3897) were 21-30 years old and male (72.7%; 2834 of 3897). No association was found between high BMI (!25 kg/m 2) and early-onset AGA. There were significantly more overweight male AGA patients than overweight female patients (86.8% [632 of 728] versus 13.2% [96 of 728], respectively). The overall prevalence of familial AGA was 72.8% (2837 of 3897) and the condition was inherited more often from the father (52.8%; 1498 of 2837) than from the mother (24.3%; 688 of 2837). Conclusions: Early-onset AGA primarily affects male patients between 21-30 years of age. Males with early-onset AGA are likely to have inherited AGA from their fathers.

Epidemiology and disease burden of androgenetic alopecia in college freshmen in China: A population-based study

“…Conversely, other studies have denied this relationship. Ding et al reported the epidemiologic data regarding AGA in Chinese young adults which No association was found between high BMI (>25 kg/m2) and early-onset AGA [ 13 ]. In consistence, our results also suggested that there was no significant association between BMI and AGA.…”

“…Consistently, Fortes et al also showed that the combination of overweight and smoking is associated with an increased severity of androgenetic alopecia [ 12 ]. However, there are also other studies demonstrating that there was no significant association between these cardiovascular risk factors (such as hypertension, smoking, BMI) and AGA [ 10 , 13 ]. For college students, it is quite rare for them to have hypertension or other cardiovascular diseases at their age.…”

Regulation and dysregulation of hair regeneration: aiming for clinical application

“…AGA, or male pattern baldness affects 30–50% men at the age of 50, and 80% men at the age of 80 (Fig. 2 A; Hamilton 1951 ; Wang et al 2010 ; Ding et al 2020 ). Thus it is a common trait in the population.…”

Comprehensive Analysis of LncRNA AC010789.1 Delays Androgenic Alopecia Progression by Targeting MicroRNA-21 and the Wnt/β-Catenin Signaling Pathway in Hair Follicle Stem Cells

“…Alopecia, a common disorder occurring worldwide, characterized by hair loss, can be caused by multiple factors, such as heredity, hormonal disorders, immune inflammation, malnutrition, environmental factors, mental disorders, and aging ( Ho and Shapiro, 2019 ). Androgen alopecia (AGA) is the most common type of alopecia and has become an important medical and social issue due to its high incidence; increasingly young onset age; and associated psychological problems, such as depression, anxiety, and emotional disorders ( Bas et al, 2015 ; Molina-Leyva et al, 2016 ; Katzer et al, 2019 ; Ding et al, 2020 ). Currently, finasteride and minoxidil are the only therapeutic drugs approved by the Food and Drug Administration for AGA treatment ( Chen et al, 2020a ).…”