Early-Onset Anemia After Kidney Transplantation Is an Independent Factor for Graft Loss

Pascual, Julio; Jiménez, Carlos; Franco, Antônio; Gil, M. Alonso; Obrador-Mulet, Aina; Gentil, M.A.; Romero, Rafael; Grinyó, Josep M.; Hernández, Domingo; Morales, José; Pallardó, Luís; Serón, Daniel; Arias, Manuel; Campistol, Josep M.

doi:10.1097/tp.0b013e31829f162e

Cited by 11 publications

(7 citation statements)

References 16 publications

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“…Our anemic patients showed up to a 23 % decrease in the measured GFR at each time point during the 10-year followup, thereby verifying the previous cross-sectional observations on the association between the poor graft function and low Hb levels [1,5,27,39,40]. EPO is the main regulator of erythropoiesis, and anemia may be attributed to insufficient EPO production by the failing graft.…”

Section: Discussionsupporting

confidence: 88%

Anemia and low-grade inflammation in pediatric kidney transplant recipients

et al. 2016

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Section: Discussionsupporting

confidence: 88%

Anemia and low-grade inflammation in pediatric kidney transplant recipients

et al. 2016

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“…We excluded 3 included studies in the previous meta-analysis due to using the impact of a 1 g/dL increase in hemoglobin level on outcomes. A total of 17 observational studies, 1–3,5–8,13–22 including 16 463 recipients, finally met the inclusion criteria and were included in the meta-analysis. Figure 1 outlines the selection process.…”

Section: Resultsmentioning

confidence: 99%

“…32 Whereas Pascual et al collected data from recipients in Spain and revealed that the prevalence of anemia after transplantation was 77% at 1 month but decreased quickly within 2 months to 41%, and more slowly later on with prevalence of 16% at 12 months and 14% at 24 months. 21 PTA has multifactorial causes and the onset of anemia can predict the causes. Recipients with early-onset PTA tend to have anemia from iron deficiency due to depletion of iron stores before transplantation, perioperative blood loss, and poor nutrition.…”

Section: Discussionmentioning

confidence: 99%

A Systematic Review and Meta-Analysis of Posttransplant Anemia With Overall Mortality and Cardiovascular Outcomes Among Kidney Transplant Recipients

et al. 2023

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Introduction: Posttransplant anemia is a common finding after kidney transplantation. A previous meta-analysis reported an association between anemia and graft loss. However, data on cardiovascular outcomes have not yet been reported. Objective: We conducted an updated meta-analysis to examine the association between posttransplant anemia and outcomes after transplantation including cardiovascular mortality in adult kidney transplant recipients. Methods: We comprehensively searched the databases of MEDLINE and EMBASE from inception to November 2021. Data from each study were combined using the random-effects model. Generic inverse variance method of DerSimonian and Laird was employed to calculate the risk ratios (RRs) and 95% confidence intervals (CIs). Results: Seventeen studies from August 2006 to April 2019 were included (16 463 kidney transplantation recipients). Posttransplant anemia was associated with overall mortality (pooled RR = 1.72 [1.39, 2.13], I2 = 56%), graft loss (pooled RR = 2.28 [1.77, 2.93], I2 = 94%), cardiovascular death (pooled RR = 2.06 [1.35, 3.16], I2 = 0%), and cardiovascular events (pooled RR = 1.33 [1.10, 1.61], I2 = 0%). Early anemia (≤ 6 months), compared with late anemia (> 6 months), has higher risk of overall mortality and graft loss with a pooled RR of 2.63 (95% CI 1.79-3.86; I2 = 0%) and 2.96 (95% CI 2.29-3.82; I2 = 0%), respectively. Discussion: In addition to increased risk of graft loss, our updated meta-analysis demonstrated that posttransplant anemia was significantly associated with poor outcomes after kidney transplantation including overall mortality, graft loss, cardiovascular death, and cardiovascular events. Future studies are required to assess the effects of treatment strategies for posttransplant anemia on posttransplant outcomes including cardiovascular mortality.

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“…Although anemia requiring blood transfusion was more frequent in both groups, it was higher in CDRT patients. Post-transplantation anemia seems to be a risk factor for graft loss, panel reactive antibody of more than 10%, acute rejection episodes [23], and mortality [24].…”

Section: Discussionmentioning

confidence: 99%