Early-Onset Cardiovascular Disease From Cocaine, Amphetamines, Alcohol, and Marijuana

Paroxysmal Sustained Ventricular Tachycardia with Cardiac Arrest and Myocardial Infarction in 29-Year-Old Man Addicted to Medical Marijuana—It Never Rains but It Pours

“…Young healthy men without cardiovascular risk factors often present with transient (classified as non-ST acute coronary syndromes) or persistent ST-segment elevations, and soared troponin concentrations with no inflammatory markers elevation or findings of myocarditis on MRI (which was observed in the presented case) [ 25 ]. Moreover, marijuana has been recognized as a significant contributor to early-onset cardiovascular diseases next to cocaine, amphetamines and alcohol [ 26 , 27 ]. A recent cross-sectional study, using pooled data from the 2017 and 2018 cohorts of the American Behavioral Risk Factor Surveillance System survey of US adults, showed that history of myocardial infarction was more frequent among recent cannabis users relative to nonusers (adjusted odds ratio [OR] 2.07, 95% CI, 1.12–3.82) and was associated with cannabis use of more than four times per month (OR 2.31, 95% CI, 1.18–4.50), and with smoking as a primary method of consumption (adjusted OR 2.01, 95% CI, 1.02–3.98) [ 28 ].…”

Cannabis, Cannabinoids, and Stroke: Increased Risk or Potential for Protection—A Narrative Review

“…Intracranial arterial stenosis is frequently discussed in the literature in the context of cannabis-induced stroke. This mechanism works on the premise that THC is causing thickening of the arterial vessel walls, leading to narrowing of the vessel lumen and reduced blood flow to the brain, which could contribute to causing an ischemic stroke [60]. Interestingly, some studies have found a link between arterial stenosis and young cannabis users who have had a stroke [61].…”