Early-Onset Colorectal Cancer: Clinico-Pathological Implications (Eocrc)

Abstract

Objective. The purpose of this study is to analyse histopathological and clinical characteristics of EOCRC. Colorectal cancer was formerly considered as a disease of senescent age; in the last years, it is a noticeable trend of growing incidence among young people (aged between 20 and 45 years). Few of newly diagnosed cases are inherited and most of them are sporadic. Material and method. The authors studied retrospectively a series of 33 cases of early onset colorectal cancer, 17 men and 16 women, with ages below 45 years, admitted between January 2009 and January 2015 in II and IV Surgical Wards of Emergency University Hospital Bucharest. Results. Colorectal cancer in young adults tends to be an aggressive disease with dominant distal location (68.5% of all cases), mostly adenocarcinomas (96.6%) with moderate to poorly differentiated types (51.4% G2 and G3), diagnosed in advanced stages (57.6% stages III and IV), with high frequency of complications (33% presented with peritoneal carcinomatosis and 9% died during hospitalization). Conclusions. EOCRC is a heterogenous group regarding etiopathogeny, localization and histopathological features of the tumor, with aggresive histopathological types, diagnosed in advanced stages. It may be necessary to elaborate new screening protocols for colorectal cancer in young adults and to fi nd clinical and biological markers that are indicating high-risk patients.

Different disease characteristics in young patients with colorectal cancer: a large retrospective study in a city in Romania

“…17 We identified only one previous study from Romania, published in 2015, in which the incidence of young-onset CRC was 5.5%. 18 The reason for the increasing incidence of CRC remains unclear, but may be associated with dietary factors such as intake of processed meat, high rates of obesity, or sedentary lifestyle. 19 Screening for CRC is recommended from the age of 50 in current guidelines in most European countries.…”