Early onset colorectal cancer in Canterbury, New Zealand

Thompson, Nasya; Gatenby, Grace; Waddell, Oliver; Purcell, Rachel; Keenan, Jacqueline I.; Pearson, John; Frizelle, F. A.; Glyn, Tamara

doi:10.1111/ans.18357

Cited by 4 publications

(2 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The age‐standardized incidence of colon cancer has increased in Sweden since 1970 while that of rectal cancer has been relatively stable [1, 2]. In both men and women <50 years in Sweden the incidence of colorectal cancer (CRC) is increasing [3, 4] in accordance with reports from other western countries [5–7].…”

Section: Introductionmentioning

confidence: 94%

Postoperative complications and emergency surgeries in colorectal cancer patients <50 years—a national cohort study

Gutlic,

Saraste,

Nordenvall

et al. 2024

Colorectal Disease

View full text Add to dashboard Cite

AimThe incidence of colorectal cancer (CRC) in Sweden is increasing in individuals <50 years. This study aimed to examine differences in postoperative 30‐day complications and rate of emergency surgeries in CRC patients <50 years at diagnosis compared to older age groups since population‐based research on this topic is scarce.MethodThis population‐based study included data from the Swedish Colorectal Cancer Registry for patients undergoing CRC resection between 2010 and 2018. Bivariate analysis and logistic regression were used to analyse the relationship between age groups (<50, 50–79 and ≥80 years) and probability of postoperative 30‐day complications adjusted for gender, tumour localization, neoadjuvant (chemo)radiotherapy and American Society of Anesthesiologists score.ResultsIn total 33 320 patients were included. Patients <50 years had a lower American Society of Anesthesiologists score, more advanced tumours and received more neoadjuvant treatment. Emergency surgeries were less common in the youngest age group (P < 0.001) as well as overall postoperative 30‐day complications: ORadj 0.84 (95% CI 0.74–0.96) compared to those ≥80 years. Surgical complications were more common in age groups <50 and 50–79 years (16.5% and 16.9% respectively) compared to patients ≥80 years (14.1%) (P < 0.001). Anastomotic leakage and intra‐abdominal infections were more frequent in patients <50 years (5.7% and 3.5% respectively) compared to age groups 50–79 years (5.1% and 2.8% respectively) and ≥80 years (3.5% and 2.1% respectively) (P < 0.001). Wound infections were more common in the two youngest age groups compared to patients ≥80 years (5.3% vs. 3.7% respectively) (P < 0.001).ConclusionColorectal cancer patients <50 years and 50–79 years had a higher proportion of surgical complications regarding anastomotic leakage, intra‐abdominal infections and wound infections but lower overall postoperative complications. The incidence of surgical emergencies was highest amongst patients ≥80 years. Postoperative diagnostic workup in symptomatic individuals <50 years is warranted.

show abstract

Section: Introductionmentioning

confidence: 94%

Postoperative complications and emergency surgeries in colorectal cancer patients <50 years—a national cohort study

Gutlic,

Saraste,

Nordenvall

et al. 2024

Colorectal Disease

View full text Add to dashboard Cite

show abstract

“…The clinical characteristics of EOCRC can differ from late-onset colorectal cancer (LOCRC, diagnosed over 50 years of age), with EOCRC more likely to be left sided (sigmoid and rectum), have higher rates of mucinous or signet ring histology, be poorly differentiated, and present with advanced (stage 3 or 4) disease [5,6]. Despite these differences, a recent meta-analysis found no overall difference in cancer specific survival between early-onset and late-onset disease [7].…”

Section: Introductionmentioning

confidence: 99%

The incidence of early onset colorectal cancer in Aotearoa New Zealand: 2000–2020

Waddell,

Pearson,

McCombie

et al. 2024

BMC Cancer

Self Cite

View full text Add to dashboard Cite

Background The incidence of early-onset colorectal cancer (EOCRC), diagnosed before age 50, has been rising in many countries in the past few decades. This study aims to evaluate this trend in Aotearoa New Zealand and assess its impact on Māori. Methods Crude incidence and age-standardized incidence of colorectal cancer (CRC) was analyzed from all new cases from the Aotearoa New Zealand national cancer registry for the period 2000–2020. Trends were estimated by sex, ethnicity, age group and location of cancer and projections made to 2040. Results Between 2000 and 2020, there were a total of 56,761 cases of CRC diagnosed in Aotearoa New Zealand, 3,702 of these being EOCRC, with age-standardized incidence decreasing significantly (P = 8.2 × 10− 80) from 61.0 to 47.3 cases per 100,000. EOCRC incidence increased on average by 26% per decade (incidence rate ratio (IRR) 1.26, p = < 0.0001) at all sites (proximal colon, distal colon and rectum), while the incidence in those aged 50–79 years decreased on average by 18% per decade (IRR 0.82, p = < 0.0005), again across all sites. There was no significant average change in CRC incidence in those over 80 years. In Māori, there was no significant change in age-standardized incidence. There was however a significant increase in crude incidence rates (IRR 1.28, p = < 0.0005) driven by significant increases in EOCRC (IRR1.36, p = < 0.0005). By 2040, we predict the incidence of EOCRC will have risen from 8.00 to 14.9 per 100,000 (6.33 to 10.00 per 100,000 in Māori). However, due to the aging population an estimated 43.0% of all CRC cases will be diagnosed in those over 80 years of age (45.9% over 70 years of age in Māori). Conclusion The age-standardized incidence of CRC from 2000 to 2020 decreased in Aotearoa New Zealand, but not for Māori. The incidence of EOCRC over the same period continues to rise, and at a faster rate in Māori. However, with the ageing of the population in Aotearoa New Zealand, and for Māori, CRC in the elderly will continue to dominate case numbers.

show abstract

PRKN-mediated the ubiquitination of IQGAP3 regulates cell growth, metastasis and ferroptosis in early-onset colorectal cancer

Chen,

Cong,

et al. 2024

J Bioenerg Biomembr

View full text Add to dashboard Cite

Early onset colorectal cancer in Canterbury, New Zealand

Cited by 4 publications

References 54 publications

Postoperative complications and emergency surgeries in colorectal cancer patients <50 years—a national cohort study

Postoperative complications and emergency surgeries in colorectal cancer patients <50 years—a national cohort study

The incidence of early onset colorectal cancer in Aotearoa New Zealand: 2000–2020

PRKN-mediated the ubiquitination of IQGAP3 regulates cell growth, metastasis and ferroptosis in early-onset colorectal cancer

Contact Info

Product

Resources

About