Early onset discordant growth in a successful monochorionic twin pregnancy

Early onset discordant growth in a successful monochorionic twin pregnancy

“…Smithson et al 1 described a case of early-onset growth discordancy in a monochorionic twin pregnancy, highlighting one of the prenatal management issues which may arise in such high risk conceptions. Discordant fetal size in the first trimester is, in fact, quite well reported in both monochorionic and dichorionic twin pregnancies.…”

“…Smithson et al 1 have highlighted that first trimester discordancy for fetal size may occur in monochorionic twin pregnancies. In all such cases, in addition to fetal crown -rump length, it is important to assess other parameters which may reflect the underlying placental vascular pattern, such as fetal nuchal translucency measurements and Doppler velocimetry of the ductus venosus 5 , in order that the most accurate assessment of risk for development of subsequent severe twin-to-twin transfusion syndrome can be provided, and hence, appropriate antenatal surveillance can be planned.…”

“…In their recent study, Djurovic et al 1 reported maternal levels of various cytokines with putative roles in the pathophysiology of impaired placentation and pre-eclampsia. Of these cytokines, they demonstrated that interleukin-10 (IL-10), an anti-inflammatory cytokine, was mainly undetectable in maternal plasma and that at approximately 18 weeks of pregnancy, there were no differences in levels between women with a normal pregnancy and those who subsequently developed pre-eclampsia.…”