Early-Onset Neonatal Sepsis: Role of C-Reactive Protein, Micro-ESR, and Gastric Aspirate for Polymorphs as Screening Markers

Kaur, Sukhdeep; Singh, Kunwarpal

doi:10.1155/2021/1544553

Cited by 5 publications

(2 citation statements)

References 17 publications

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“…So, CRP is an important factor in evaluating the treatment process. Also, CRP is considered a valuable marker with a sensitivity of 87.5% and a specificity of 90.5% in neonatal septicemia (23). Thus, CRP estimation can help in identifying neonatal sepsis, but it is not accurate enough to be the sole criterion for diagnosis (24).…”

Section: Discussionmentioning

confidence: 99%

Bacterial Etiology and Antibiotic Susceptibility Profile in Neonatal Sepsis

Oboodi,

Hashemi,

Jaafarzadeh

et al. 2024

Arch Pediatr Infect Dis

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Background: Sepsis is a leading cause of morbidity and mortality in neonates. Objectives: This study aimed to investigate the bacterial profile and antibiotic sensitivity in infants with sepsis. Methods: This cross-sectional study was conducted on 90 neonates with sepsis admitted to the neonatal intensive care unit of Namazi Hospital, a tertiary-level hospital, in Shiraz, Iran, from 2020 to 2021. Demographic and clinical data including gestational age, previous diseases, maternal infectious, underlying diseases, history and duration of premature rupture of the membrane and delivery, clinical symptoms (fever, reduced breastfeeding, and lethargy), laboratory results (complete blood cell and C-reactive protein), and results of blood and urine cultures were recorded and analyzed. Results: Among 90 neonates with sepsis, the average age was 6.7 ± 7.6 days; 54 were male (60.0%), and 36 were female (40.0%). Fifty (55.5%) neonates had early sepsis. Gram-negative organisms were grown in 61% of positive blood cultures; the most common was Klebsiella. Among Gram-positive organisms, Staphylococcus epidermidis was the most common. Most organisms were sensitive to colistin, and most were resistant to cefotaxime. There was a significant relationship between the age of onset of sepsis symptoms and birth weight in infants with positive blood cultures (P = 0.004) (r = 0.3). Conclusions: Gram-negative bacteria are the most common causes of sepsis, mainly resistant to aminoglycosides and cefotaxime. Therefore, increasing awareness about the optimal use of antibiotics is necessary to curb the increase in resistance levels.

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Section: Discussionmentioning

confidence: 99%

Bacterial Etiology and Antibiotic Susceptibility Profile in Neonatal Sepsis

Oboodi,

Hashemi,

Jaafarzadeh

et al. 2024

Arch Pediatr Infect Dis

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“…Kaur et al evaluated different parameters of neonatal sepsis to create strategy for early diagnosis and found that CRP had highest sensitivity (87%) at > 6 mg/L [21] while Ganesan et al based-on CRP >13.495 mg/L reported sensitivity of 80% and specificity of 65.7% [16]. One study showed that serial monitoring of CRP along with cytokines IL-6 and IL-8 would be helpful in improving diagnostic accuracy of sepsis and evaluating the antibiotic response [10].…”

Section: Discussionmentioning

confidence: 99%

The clinical significance of CRP and IL-6 in early recognition of neonatal sepsis

Aslam,

Sipra,

Zakir

et al. 2024

Pak J Pathol

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Objective: The aim of this study was to determine serum CRP and IL-6 levels in confirmed and clinically suspected groups of neonatal sepsis and these biochemical parameters are being compared with blood culture of neonates with clinical signs and symptoms of sepsis. Material and Methods: The samples of 180 suspected cases of neonatal sepsis were sent to pathology department. Out of them 92 were proven positive for blood culture and were considered as confirmed septic group while rests were included in clinically suspected group. Blood culture was performed on BACT/ALERT® 3D. Serum CRP was performed by immunoturidimetric method on AU 680 Beckman Coulter and IL-6 measurement was done on Access 2. Results: The serum CRP and IL-6 levels were higher in confirmed sepsis group and their levels were in correspondence to severity of infection. At cut off values of >10mg/L, CRP showed sensitivity of 94%, and specificity of 74% while at cut off of >35ng/L, IL-6 had sensitivity and specificity of 70% and 88% respectively. Conclusion: The results of this study suggested that CRP was a highly sensitive marker and IL-6 was a more specific for detection of neonatal sepsis. Keywords: neonatal sepsis, CRP, IL-6

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Assessment of the clinical and laboratory risk factors for thrombosis in neonates admitted to neonatal intensive care unit (two Egyptian tertiary centers experience)

Abdelsamei,

Hakeem,

El Amin

et al. 2024

Ann Hematol

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In neonates admitted to the neonatal intensive care unit (NICU), arterial and venous thromboembolism is a major cause of morbidity and death which could be attributed to multiple risk factors exposure. This study aimed to evaluate the clinical characteristics, laboratory and radiological assessments, predisposing risk factors, and outcomes of thrombosis in neonates admitted to NICU. This prospective cohort study was conducted at NICU, Minia, and Alexandria University Children’s Hospital. Screening of 886 patients admitted to NICU over one year with different clinical presentations, patients were classified into the thrombotic and non-thrombotic groups based on the presence or absence of thrombosis. Thrombosis was diagnosed based on clinical, laboratory and different radiologic assessments. Genetic testing for factor V Leiden mutations G1691A, prothrombin mutation G20210A, protein C, protein S, and antithrombin III gene mutations were performed for patients with a family history of thrombosis. Out of a total of 886 neonatal admissions, 36 patients were diagnosed with evident thrombosis (40 per 1000 NICU admissions). The sites of venous thrombosis detection were Portal vein thrombosis in 11 patients (30.6%), superior vena cava thrombosis in 7 patients (19.4%), deep venous thrombosis in 5 patients (13.9%), central venous thrombosis in 5 patients (13.9%), intra-cardiac thrombosis in 3 patients (8.3%) and necrotic skin patches in one patient (2.8%). Only 69% of enrolled thrombosis patients showed genetic mutations the most common of which was factor V Leiden mutation (52.3%). Sepsis, central venous line (CVL) insertion, C reactive protein (CRP), and duration of NICU admission were significantly more common in the thrombotic group (p < 0.001) and were associated with a higher risk of thrombosis (ORs: 1.02, 7.7, and 1.11, respectively) (p < 0.001). Higher mortality occurred in thrombosis neonates compared with a non-thrombotic group (52.8% versus 17.4%) (p < 0.001). NICU-admitted neonates are exposed to multiple overlapped risk factors, the detection of which is important for preventing potential thrombosis and improving the patient’s outcomes. The complexity of sepsis pathogenesis and management could potentiate multiple acquired risk factors. inherited thrombophilia detection is required for prevention of further morbidities.

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Early-Onset Neonatal Sepsis: Role of C-Reactive Protein, Micro-ESR, and Gastric Aspirate for Polymorphs as Screening Markers

Cited by 5 publications

References 17 publications

Bacterial Etiology and Antibiotic Susceptibility Profile in Neonatal Sepsis

Bacterial Etiology and Antibiotic Susceptibility Profile in Neonatal Sepsis

The clinical significance of CRP and IL-6 in early recognition of neonatal sepsis

Assessment of the clinical and laboratory risk factors for thrombosis in neonates admitted to neonatal intensive care unit (two Egyptian tertiary centers experience)

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