Early Onset of Leuko-araiosis in Hypertensive Patients

Domínguez, Raúl; Famulari, A.; García, Gerardo; Bartolomé, E.; D'Abraccio, Graciela; Vila, José F.; Gallo, Alberto S.; Cannata, M. A.

doi:10.1001/archneur.1993.00540010009006

Cited by 5 publications

(1 citation statement)

References 12 publications

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“…12 Chronic arterial hypertension and DM type 2 are the main risk factors for developing chronic ischaemia in white matter. 13 Microvascular disease is frequent in diabetes 14,15 ; it contributes to cognitive impairment and causes clinical manifestations similar to those of Alzheimer disease. There have been fewer studies of diabetes mellitus type 1, and its links to cognitive impairment are still not universally accepted.…”

Section: Vascular Damagementioning

confidence: 99%

Alzheimer disease and cognitive impairment associated with diabetes mellitus type 2: associations and a hypothesis

Domínguez

Pagano

Marschoff

et al. 2014

Neurología (English Edition)

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Introduction: Epidemiological studies have demonstrated that patients with diabetes mellitus have an increased risk of developing Alzheimer disease, but the relationship between the 2 entities is not clear. Development:Both diseases exhibit similar metabolic abnormalities: disordered glucose metabolism, abnormal insulin receptor signalling and insulin resistance, oxidative stress, and structural abnormalities in proteins and ␤-amyloid deposits. Different hypotheses have emerged from experimental work in the last two decades. One of the most comprehensive relates the microvascular damage in diabetic polyneuritis with the central nervous system changes occurring in Alzheimer disease. Another hypothesis considers that cognitive impairment in both diabetes and Alzheimer disease is linked to a state of systemic oxidative stress. Recently, attenuation of cognitive impairment and normalisation of values in biochemical markers for oxidative stress were found in patients with Alzheimer disease and concomitant diabetes. Antidiabetic drugs may have a beneficial effect on glycolysis and its end products, and on other metabolic alterations.ଝ Please cite this article as: Domínguez RO, Pagano MA, Marschoff ER, González SE, Repetto MG, Serra JA. Enfermedad de Alzheimer y deterioro cognitivo asociado a la diabetes mellitus de tipo 2: relaciones e hipótesis. Neurología.

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Section: Vascular Damagementioning

confidence: 99%

Alzheimer disease and cognitive impairment associated with diabetes mellitus type 2: associations and a hypothesis

Domínguez

Pagano

Marschoff

et al. 2014

Neurología (English Edition)

View full text Add to dashboard Cite

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Enfermedad de Alzheimer y deterioro cognitivo asociado a la diabetes mellitus de tipo 2: relaciones e hipótesis

Domínguez¹,

Pagano²,

Marschoff³

et al. 2014

Neurología

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Diabetic patients are at increased risk for developing Alzheimer disease, but paradoxically, their biochemical alterations and cognitive impairment are less pronounced than in groups of dementia patients without diabetes. A deeper understanding of interactions between the pathogenic processes of both entities may lead to new therapeutic strategies that would slow or halt the progression of impairment.

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