Early Onset of Muscle Atrophy in Women with Chronic Alcoholic Myopathy

Zinovyeva, O. E.; Samhaeva, N. D.; Kazakov, D.; Turtikova, O. V.; Носовский, А. М.; Шенкман, Борис; Nemirovskaya, T. L.

doi:10.1134/s0362119718030179

Cited by 2 publications

(3 citation statements)

References 6 publications

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“…More recently, it was reported that after 14 wk of consuming an EtOH-containing diet, reductions in rat gastrocnemius muscle mass were similar between sexes (~20% vs sex-matched controls) (68). In reference to humans, type II fiber atrophy of the vastus lateralis was reported to be over 40% in females after 5-7 yr of chronic alcohol intake, whereas no significant atrophy was present in males after a similar duration of alcohol misuse (25)(26)(27). Interestingly, in these human studies, chronic consumption of EtOH increased ubiquitinated protein content in both male and female subjects, yet only female muscle upregulated ubiquitin ligase expression (26,27).…”

Section: Discussionmentioning

confidence: 99%

“…In general, muscle weakness can stem from reduced neuromuscular excitation, skeletal muscle quantity (i.e., size), and/or muscle quality (i.e., contraction efficiency). Chronic alcohol consumption primarily leads to atrophy of type II muscle fibers as evidenced by loss of fiber cross-sectional area (CSA) (7,(22)(23)(24)(25)(26)(27). Reductions in fiber CSA or size, in both rodents and humans, are thought to be due to disturbances in protein synthesis and degradation as a result of alcohol-induced alterations in anabolic and catabolic signaling (14,19,23,28,29).…”

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confidence: 99%

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Excessive Ethanol Intake in Mice Does Not Impair Recovery of Torque after Repeated Bouts of Eccentric Contractions

Moser

Brown

Ganjayi

et al. 2023

Medicine &Amp; Science in Sports &Amp; Exercise

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Alcoholics develop muscle atrophy and weakness from excessive ethanol (EtOH) intake. To date, most research has examined outcomes of alcohol-induced atrophy and weakness under basal or unstressed conditions despite physical stress being a normal occurrence in a physiological setting. Therefore, this study set out to determine if recovery of torque is impaired after repetitive bouts of physical stress in skeletal muscle during excessive short-term (experiment 1) and long-term (experiment 2) EtOH consumption. Methods: Twenty male and female mice were assigned to receive either 20% EtOH in their drinking water or 100% water. Short-and long-term consumption was predetermined to be EtOH intake starting at 4 and 26 wk, respectively. Anterior crural muscles performed repeated bouts of physical stress using in vivo eccentric contractions, with tetanic isometric torque being measured immediately pre-and postinjury. A total of 10 bouts were completed with 14 d between each bout within bouts 1-5 (experiment 1) and bouts 6-10 (experiment 2), and 12 wk between bouts 5 and 6. Results: Mice consuming EtOH had blood alcohol concentrations up to 270 mg•dL −1 . In experiment 1, five bouts of eccentric contractions did not reduce recovery of torque, regardless of sex or EtOH treatment (P ≥ 0.173). Similarly, in experiment 2, preinjury torques did not differ from day 14 values regardless of sex or treatment (P ≥ 0.322). However, there was a group effect in female mice for bouts 6 and 10 during experiment 2, with female EtOH mice being weaker than controls (P ≤ 0.002). Conclusions: Excessive short-or long-term EtOH misuse in a mouse model did not affect the muscle's ability to regain strength after repeated bouts of eccentric contractions, suggesting that EtOH may not be as detrimental to recovery as once predicted.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Excessive Ethanol Intake in Mice Does Not Impair Recovery of Torque after Repeated Bouts of Eccentric Contractions

Moser

Brown

Ganjayi

et al. 2023

Medicine &Amp; Science in Sports &Amp; Exercise

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“…It is well documented that chronic alcoholics have lower muscle mass and strength compared to healthy controls, resulting in poor quality of life after several years of misuse (Aagaard et al, 2003; Ekbom et al, 1964; Estruch et al, 1998; Martin et al, 1985; Nemirovskaya et al, 2015; Rossow et al, 1976; Shenkman et al, 2018, 2019; Urbano‐Márquez et al, 1995; Vancampfort et al, 2020; Zinovyeva et al, 2018). In fact, among patients with liver disease, those with cirrhosis due to chronic alcohol consumption had the lowest muscle area and greatest standardized rate of muscle loss (Welch et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Longitudinal assessment of strength and body composition in a mouse model of chronic alcohol‐related myopathy

Ganjayi

Brown

Baumann

2023

Alcohol: Clinical and Experimental Research

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BackgroundExcessive, chronic alcohol consumption can result in muscle atrophy and weakness (i.e., alcoholic myopathy) that impairs the quality of life. However, the precise mechanisms responsible for ethanol's detrimental impact on skeletal muscle have not been fully elucidated, in part due because the time course of disease development and progression are not well established. Therefore, we examined muscle strength and body composition longitudinally using an established preclinical mouse model of chronic alcoholic myopathy.MethodsTo establish a time course of chronic alcoholic myopathy, we fed High Drinking in the Dark (HDID) female mice (n = 7) 20% ethanol for ~32 weeks (following a 2‐week ethanol ramping period). We assessed in vivo isometric contractility of the left ankle dorsiflexor and lean mass via NMR every 4 weeks. Outcomes were compared with age‐matched control HDID mice that did not consume ethanol (n = 8).ResultsAt study completion, mice who consumed ethanol were 12% weaker than control mice (p = 0.015). Compared to baseline, consuming ethanol resulted in an acute transient reduction in dorsiflexion torque at Week 4 (p = 0.032) that was followed by a second, more sustained reduction at Week 20 (p < 0.001). Changes in lean mass paralleled those of dorsiflexor torque, with ~40% of the variance in dorsiflexor torque being explained by the variance in lean mass of the ethanol group (p < 0.001). Dorsiflexor torque normalized to lean mass (mN·m/g lean mass) did not differ between the ethanol and control groups from Weeks 4 to 32 (p ≥ 0.498).ConclusionsThese results indicate that reductions in muscle mass and strength due to chronic, excessive ethanol intake are dynamic, not necessarily linear, processes. Moreover, the findings confirm that ethanol‐induced weakness is primarily driven by muscle atrophy (i.e., loss of muscle quantity). Future studies should consider how chronic alcoholic myopathy develops and progresses rather than identifying changes after it has been diagnosed.

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Early Onset of Muscle Atrophy in Women with Chronic Alcoholic Myopathy

Cited by 2 publications

References 6 publications

Excessive Ethanol Intake in Mice Does Not Impair Recovery of Torque after Repeated Bouts of Eccentric Contractions

Excessive Ethanol Intake in Mice Does Not Impair Recovery of Torque after Repeated Bouts of Eccentric Contractions

Longitudinal assessment of strength and body composition in a mouse model of chronic alcohol‐related myopathy

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