Early onset of severe diabetes mellitus-related microvascular complications

Hamilton, J. R.; Brown, Maryanne; Silver, Robert J.; Daneman, Denis

doi:10.1016/j.jpeds.2003.10.060

Cited by 4 publications

(2 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There are a few case reports of complications developing in the first few months or years after diagnosis of diabetes even in the face of near normoglycemia [67]. In 6 cases reported in the literature, neuropathy (4/6) and retinopathy (6/6) were distinctly more common than nephropathy (1/6) [67].…”

Section: Microvascular Complicationsmentioning

confidence: 99%

“…In 6 cases reported in the literature, neuropathy (4/6) and retinopathy (6/6) were distinctly more common than nephropathy (1/6) [67]. These cases highlight the need for clinical vigilance even early in the course of type 1 diabetes irrespective of metabolic control and particularly perhaps in those with a long prodrome of hyperglycemic symptoms.…”

Section: Microvascular Complicationsmentioning

confidence: 99%

See 1 more Smart Citation

Early Diabetes-Related Complications in Adolescents

Daneman

2005

Horm Res Paediatr

Self Cite

View full text Add to dashboard Cite

Micro- and macrovascular complications account for the major part of the morbidity and mortality associated with diabetes developing in childhood. Although advanced complications are exceptionally rare in the adolescent age group, it is during this phase that the progression of risk may accelerate. A number of potentially important factors have been identified which might contribute to risk of complication development: some provide insights into the genetics of these complications, while others are potentially modifiable, such as metabolic control, hypertension, smoking, obesity and hyperlipidemia. Recently, both consensus and evidence-based guidelines have been developed to guide those involved in the care of adolescents with diabetes in the prevention, screening and management of early diabetes-related complications in this vulnerable population. This article reviews the literature that underpins the available guidelines and stresses the pivotal role of excellent metabolic control in complication prevention.

show abstract

Section: Microvascular Complicationsmentioning

confidence: 99%

Section: Microvascular Complicationsmentioning

confidence: 99%

Early Diabetes-Related Complications in Adolescents

Daneman

2005

Horm Res Paediatr

Self Cite

View full text Add to dashboard Cite

show abstract

Early onset of proliferative retinopathy in patients with type I diabetes of <5 years' duration

Bouhanick

2004

The Journal of Pediatrics

View full text Add to dashboard Cite

Epidemiology, risk factors and management of paediatric diabetic retinopathy: Table 1

2012

View full text Add to dashboard Cite

Diabetic retinopathy (DR), a common complication of both type 1 and type 2 diabetes, is rarely expressed at a level greater than background retinopathy during childhood and adolescence. Epidemiological studies in paediatric diabetic patients together with data from the Diabetes Control and Complications Trial have demonstrated the importance of glycaemic control in delaying or preventing the development of DR; thus, the incidence of DR has declined somewhat over the past two decades. Both prepubertal and postpubertal years with diabetes contribute to the overall probability of DR development. In addition to duration of disease and degree of glycaemic control, other risk factors for DR development include elevated blood pressure, lipid profiles, serum levels of advanced glycation endproducts, evidence for early stage atherosclerosis, increased calibre of retinal blood vessels and several genetic factors, such as enzymes involved in glucose and lipid metabolism. Annual screening is recommended, with mydriatic stereoscopic fundus photography being the most sensitive detection method. Both pathophysiology and treatment in paediatric populations are essentially the same as described for adult populations, with treatment usually not required until adulthood is reached.

show abstract

Early onset of severe diabetes mellitus-related microvascular complications

Cited by 4 publications

References 18 publications

Early Diabetes-Related Complications in Adolescents

Early Diabetes-Related Complications in Adolescents

Early onset of proliferative retinopathy in patients with type I diabetes of <5 years' duration

Epidemiology, risk factors and management of paediatric diabetic retinopathy: Table 1

Contact Info

Product

Resources

About