Early optical detection of cerebral edema in vivo

Gill, Amandip S; Rajneesh, Kiran; Owen, Christopher; Yeh, James; Hsu, Mike S.; Binder, Devin K.

doi:10.3171/2010.2.jns091017

Cited by 31 publications

(21 citation statements)

References 27 publications

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“…26,27 Combining the STC concept with retinal thickness estimation tasks might improve the diagnostic accuracy and contribute to development of enhanced computer-aided detection algorithms. 28 Also, OCT has recently emerged as the modality to estimate cerebral edema as well as to image cerebral cortex and subcortical structures, 29 where the proposed STC concept may also have significant utility.…”

Section: Discussionmentioning

confidence: 99%

Spatiotemporal correlation of optical coherence tomographyin-vivoimages of rabbit airway for the diagnosis of edema

et al. 2015

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Abstract. Detection of an early stage of subglottic edema is vital for airway management and prevention of stenosis, a life-threatening condition in critically ill neonates. As an observer for the task of diagnosing edema in vivo, we investigated spatiotemporal correlation (STC) of full-range optical coherence tomography (OCT) images acquired in the rabbit airway with experimentally simulated edema. Operating the STC observer on OCT images generates STC coefficients as test statistics for the statistical decision task. Resulting from this, the receiver operating characteristic (ROC) curves for the diagnosis of airway edema with full-range OCT in-vivo images were extracted and areas under ROC curves were calculated. These statistically quantified results demonstrated the potential clinical feasibility of the STC method as a means to identify early airway edema. © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Section: Discussionmentioning

confidence: 99%

Spatiotemporal correlation of optical coherence tomographyin-vivoimages of rabbit airway for the diagnosis of edema

et al. 2015

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“…Durch die limitierte Eindringtiefe betrifft dies v. a. den Hirnstamm und die mittlere sowie hintere Zirkulation. In welchem Ausmaß ein subdurales oder extrazerebrales Hämatom eine Messung der zerebralen rSO 2 störend beeinflusst, konnte bisher nicht endgültig geklärt werden [16,49].…”

Section: Zerebrale Oxymetrieunclassified

Nahinfrarotspektroskopie unter kardiopulmonaler Reanimation und mechanischer Kreislaufunterstützung

Wally

Velik‐Salchner

2015

Med Klin Intensivmed Notfmed

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NIRS is a rapidly available, user-friendly, and noninvasive method for continuous measurement of rSO2. NIRS provides additional information about tissue oxygenation especially during resuscitation and extracorporeal circulatory assist support. Recommendations concerning the use of NIRS for standard monitoring during resuscitation and mechanical circulatory support are not currently available. Further studies are required to show if use of NIRS can reduce pulse control and hands-off times during resuscitation and if use of NIRS can improve outcome after CPR and mechanical circulatory support.

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“…After the treatment procedure, brains were dissected out postmortem, separated into four pieces (right-left cerebral hemispheres and right-left cerebellum pieces), and subjected to wet-dry weight comparisons to determine percent water content, as previously described. 21,22 Intergroup comparisons of brain tissue water content were done using one-way analysis of variance and post-hoc Bonferroni's tests. Brain tissue water content is presented as mean -SEM.…”

Section: Surgical Technique and Controlled Cortical Impact Modelmentioning

confidence: 99%

Reduction of Cerebral Edema after Traumatic Brain Injury Using an Osmotic Transport Device

McBride

Szu

Hale

et al. 2014

Journal of Neurotrauma

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Traumatic brain injury (TBI) is significant, from a public health standpoint, because it is a major cause of the morbidity and mortality of young people. Cerebral edema after a TBI, if untreated, can lead to devastating damage of the remaining tissue. The current therapies of severe TBI (sTBI), as outlined by the Brain Trauma Foundation, are often ineffective, thus a new method for the treatment of sTBI is necessary. Herein, the reduction of cerebral edema, after TBI, using an osmotic transport device (OTD) was evaluated. Controlled cortical impact (CCI) was performed on adult female CD-1 mice, and cerebral edema was allowed to form for 3 h, followed by 2 h of treatment. The treatment groups were craniectomy only, craniectomy with a hydrogel, OTD without bovine serum albumin (BSA), and OTD. After CCI, brain water content was significantly higher for animals treated with a craniectomy only, craniectomy with a hydrogel, and OTD without BSA, compared to that of control animals. However, when TBI animals were treated with an OTD, brain water content was not significantly higher than that of controls. Further, brain water content of TBI animals treated with an OTD was significantly reduced, compared to that of untreated TBI animals, TBI animals treated with a craniectomy and a hydrogel, and TBI animals treated with an OTD without BSA. Here, we demonstrate the successful reduction of cerebral edema, as determined by brain water content, after TBI using an OTD. These results demonstrate proof of principle for direct water extraction from edematous brain tissue by direct osmotherapy using an OTD.

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Early optical detection of cerebral edema in vivo

Abstract: Compared with traditional ICP monitoring, the aforementioned minimally invasive NIR techniques allow for the significantly earlier detection of cerebral edema, which may be of clinical utility in the identification and thus early treatment of cerebral edema.

Cited by 31 publications

References 27 publications

Spatiotemporal correlation of optical coherence tomographyin-vivoimages of rabbit airway for the diagnosis of edema

Spatiotemporal correlation of optical coherence tomographyin-vivoimages of rabbit airway for the diagnosis of edema

Nahinfrarotspektroskopie unter kardiopulmonaler Reanimation und mechanischer Kreislaufunterstützung

Reduction of Cerebral Edema after Traumatic Brain Injury Using an Osmotic Transport Device

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