Early oral colostrum administration in preterm infants

Maffei, Diana; Brewer, Mariana R.; Codipilly, Champa N; Weinberger, Barry; Schanler, Richard J.

doi:10.1038/s41372-019-0556-x

Cited by 27 publications

(25 citation statements)

References 14 publications

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“…Additionally, there is evidence for better developmental outcomes of premature infants when fed with their own mothers' milk compared to the mismatched milk of an anonymous donor (eg, De Halleux et al, 2019; Heiman & Schanler, 2006; Montjaux‐Régis et al, 2011). The oral administration of the mother's colostrum to preterm neonates additionally canalizes their oral microbiota and immunity (Glass, Greecher, & Doheny, 2017; Maffei, Brewer, Codipilly, Weinberger, & Schanler, 2020; Snyder et al, 2017), but it may also subject them to chemosensory incentives. Finally, suffusing own mother's milk odor into the incubator quasi‐continuously for 3 days promotes the psychophysiological stabilization of preterm infants (Park & Im, 2020), further suggesting sustained adaptive effects of the odor of age‐matched milk.…”

Section: Discussionmentioning

confidence: 99%

Human neonates prefer colostrum to mature milk: Evidence for an olfactory bias toward the “initial milk”?

Klaey-Tassone

Durand

Damon

et al. 2020

American J Hum Biol

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Objectives Colostrum is the initial milk secretion which ingestion by neonates warrants their adaptive start in life. Colostrum is accordingly expected to be attractive to newborns. The present study aims to assess whether colostrum is olfactorily attractive for 2‐day‐old newborns when presented against mature milk or a control. Methods The head‐orientation of waking newborns was videotaped in three experiments pairing the odors of: (a) colostrum (sampled on postpartum day 2, not from own mother) and mature milk (sampled on average on postpartum day 32, not from own mother) (n tested newborns = 15); (b) Colostrum and control (water; n = 9); and (c) Mature milk and control (n = 13). Results When facing the odors of colostrum and mature milk, the infants turned their nose significantly longer toward former (32.8 vs 17.7% of a 120‐s test). When exposed to colostrum against the control, they responded in favor of colostrum (32.9 vs 16.6%). Finally, when the odor of mature milk was presented against the control, their response appeared undifferentiated (26.7 vs 28.6%). Conclusions These results indicate that human newborns can olfactorily differentiate conspecific lacteal fluids sampled at different lactation stages. They prefer the odor of the mammary secretion ‐ colostrum ‐ collected at the lactation stage that best matches the postpartum age of their own mother. These results are discussed in the context of the earliest mother‐infant chemo‐communication. Coinciding maternal emission and offspring reception of chemosignals conveyed in colostrum may be part of the sensory precursors of attunement between mothers and infants.

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Section: Discussionmentioning

confidence: 99%

Human neonates prefer colostrum to mature milk: Evidence for an olfactory bias toward the “initial milk”?

Klaey-Tassone

Durand

Damon

et al. 2020

American J Hum Biol

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“…Given the biological role of colostrum for neonates ( 8 , 162 ), its documented bioactive components as outlined here, and the potential for development as a functional food or food ingredient. There is a significant interest in developing colostrum as an ingredient to improve the bioactivity of foods and/or their potential health benefits.…”

Section: Future Directionsmentioning

confidence: 99%

Bovine Colostrum and Its Potential for Human Health and Nutrition

et al. 2021

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Colostrum is the first milk produced post-partum by mammals and is compositionally distinct from mature milk. Bovine colostrum has a long history of consumption by humans, and there have been a number of studies investigating its potential for applications in human nutrition and health. Extensive characterization of the constituent fractions has identified a wealth of potentially bioactive molecules, their potential for shaping neonatal development, and the potential for their application beyond the neonatal period. Proteins, fats, glycans, minerals, and vitamins are abundant in colostrum, and advances in dairy processing technologies have enabled the advancement of bovine colostrum from relative limitations of a fresh and unprocessed food to a variety of potential applications. In these forms, clinical studies have examined bovine colostrum as having the substantial potential to improve human health. This review discusses the macro-and micronutrient composition of colostrum as well as describing well-characterized bioactives found in bovine colostrum and their potential for human health. Current gaps in knowledge are also identified and future directions are considered in order to elevate the potential for bovine colostrum as a component of a healthy diet for a variety of relevant human populations.

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“…2), and the lower cream-colored watery part at the bottom of the tube extracted and used for pouring into the mouth by using a syringe. A study by Maffei et al (28) investigated early oral colostrum administration in preterm neonates; Infants who received the oral colostrum by syringe had signi cantly higher urinary secreted immunoglobulin A and lactoferrin comparing to using a swab. Many studies have suggested early breastfeeding initiation (< 24 h), which leads to a decrease in the mortality rate in the newborn (28) (29).…”

Section: Discussionmentioning

confidence: 99%

The Effect of Breast Milk Cells on the Clinical Outcomes of Neonates With Birth Weight Equal to or Less Than 1800 Grams: a Randomized Controlled Trial

Fallahi¹,

Shafiei²,

Taleghani³

et al. 2020

Preprint

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Background: Most premature and very low birth weight infants cannot tolerate feedings in the first few days of life and are deprived of breast milk's beneficial effects. This study aims to evaluate the breast milk cells' effects on neonates' clinical outcomes with a birth weight of ≤1800 grams.Methods: This research is a randomized controlled trial conducted on 156 infants in the neonatal intensive care unit of Mahdieh maternity Hospital in Tehran, Iran, from May 2019 to April 2020. All neonates with a birth weight of ≤1800 grams were enrolled and randomly divided into intervention and control groups. During the first 6-12 hours of delivery, neonates in the intervention group received the extracted breast milk cells (BMCs) provided by centrifuging their own mothers' breast milk for one time. Demographic data and clinical outcomes were compared between the two groups. We also had a subgroup analysis in neonates with birth weight less than 1500 grams.Results: A total of 156 neonates entered the final analysis. We divided participants into two groups by using a computer-generated block randomization sequence, including 75 patients in the intervention group and 81 neonates in the control group. The mean birth weight of neonates was 1390.1±314.4 grams, with a total mortality rate of 12.2% (n=19). We found that in-hospital mortality was significantly lower in neonates who received BMCs (6.7% vs. 17.3%; P-value: 0.043) compared to the control group, and it was more prominent in neonates with birth weight less than 1500 grams (9.5% vs. 30.2%; P-value: 0.017). We did not find any other significant differences in major complications such as retinopathy of prematurity, necrotizing enterocolitis, and bronchopulmonary dysplasia between the two groups.Conclusion: Our research demonstrated a significantly lower mortality rate in neonates (with a birth weight of ≤1800 grams) who received breast milk cells on the first day of life. Since this is a novel method with minimal intervention, we are looking forward to developing and evaluating this method in larger studies, with more frequent use of BMCs in very low birth weight infants.Trial registration: Iranian Registry of Clinical Trials, IRCT20190228042868N1. Registered 25 May 2019, https://irct.ir/trial/38230.

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Early oral colostrum administration in preterm infants

Cited by 27 publications

References 14 publications

Human neonates prefer colostrum to mature milk: Evidence for an olfactory bias toward the “initial milk”?

Human neonates prefer colostrum to mature milk: Evidence for an olfactory bias toward the “initial milk”?

Bovine Colostrum and Its Potential for Human Health and Nutrition

The Effect of Breast Milk Cells on the Clinical Outcomes of Neonates With Birth Weight Equal to or Less Than 1800 Grams: a Randomized Controlled Trial

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