Early osseointegration to hydrophilic and hydrophobic implant surfaces in humans

Lang, Niklaus P.; Salvi, Giovanni E.; Huynh‐Ba, Guy; Ivanovski, Sašo; Donos, Nikolaos; Bosshardt, Dieter D.

doi:10.1111/j.1600-0501.2011.02172.x

Cited by 399 publications

(473 citation statements)

References 22 publications

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“…In this context, in vivo studies have shown that the SLActive surface is associated with an earlier onset of osseointegration 3,4) . As the biological processes of inflammation and bone formation have been shown to be inversely related during osseointegration 5) it can be reasonably suggested that the higher platelet activation associated with this surface could contribute to minimizing the inflammatory period through the enhanced recruitment and degranulation of neutrophils which would in turn speed up the onset of the healing/ osteogenic phase.…”

Section: Discussionmentioning

confidence: 99%

“…Surface micro-roughness, such as that obtained in sand blasted and acid etched (SLA) implants, has been well recognized to promote osseointegration when compared with smoother surfaces 1) . Further modification of the SLA surface leading to increased hydrophilicity (SLActive), has been shown in recent human in vivo studies to be associated with even further acceleration of the onset of osseointegration 2,3) . However, the underlying biological mechanisms responsible for these observations have not been fully elucidated.…”

Section: Introductionmentioning

confidence: 99%

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Titanium surface hydrophilicity enhances platelet activation

2014

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Titanium implant surface modification is a key strategy used to enhance osseointegration. Platelets are the first cells that interact with the implant surface whereupon they release a wide array of proteins that influence the subsequent healing process. This study therefore investigated the effect of titanium surface modification on the attachment and activation of human platelets. The surface characteristics of three titanium surfaces: smooth (SMO), micro-rough (SLA) and hydrophilic micro-rough (SLActive) and the subsequent attachment and activation of platelets following exposure to these surfaces were determined. The SLActive surface showed the presence of significant nanoscale topographical features. While attached platelets appeared to be morphologically similar, significantly fewer platelets attached to the SLActive surface compared to both the SMO and SLA surfaces. The SLActive surface however induced the release of the higher levels of chemokines β-thromboglobulin and platelet factor 4 from platelets. This study shows that titanium surface topography and chemistry have a significant effect on platelet activation and chemokine release.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Titanium surface hydrophilicity enhances platelet activation

2014

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“…29 These experimental outcomes were confirmed not only by prospective clinical studies in which implants were loaded after 21 days of bone repair, 33,34 but also by studies measuring implant stability with the aid of resonance frequency analysis (RFA), 35 genetic expression profile and histological analysis of human models. 36,37 As regards the use of antibiotics, a recent systematic review concluded that scientific evidence suggests that, in general, this type of drug is advantageous, as it aids reducing failure rates of implants placed under normal conditions. 38 …”

Section: Discussionmentioning

confidence: 99%

Bilateral sinus floor augmentation using 100% alloplastic biomaterial for later rehabilitation of atrophic maxilla. A 5-year tomographic follow-up

Bucco¹,

Silva²,

Miranda³

et al. 2015

Dental Press Implantol

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“…The samples were collected from five animals for each experimental period (7,14,21 and 28 days). The animals were maintained alive after biopsy.…”

Section: Histologic Specimens Preparation and Maintenance Of Animals mentioning

confidence: 99%

“…In this analysis, both implants tested are commercially available; however, regulators and professionals must have evidence that demonstrate the safety and efficacy of these products based on standardized protocols in order to reduce the use of inefficient products (6,14).…”

Section: Introductionmentioning

confidence: 99%

Accelerated Healing Period with Hydrophilic Implant Placed in Sheep Tibia

et al. 2017

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The objective of this study was to evaluate the early osseointegration of two different implants surfaces, a sandblasted and acid-etched surface (TN) compared with same geometry and surface roughness modified to be hydrophilic/wettable by conditioning in an isotonic solution of 0.9% sodium-chloride (TA) through histological and histomorphometric analysis after sheep tibia implantation. Forty dental implants, divided in two groups (TN and TA) were placed in the left tibia of twenty healthy, skeletally mature Santa Ines sheep (n=5/experimental period). After 7, 14, 21 and 28 days post-implantation, the samples were removed and the sheep were kept alive. Analysis of resin sections (30 μm) allowed the quantification of bone area (BA) and bone-to-implant contact (BIC). TA group presented nearly 50% increase in BA at 14 days (p<0.001, ANOVA -Tukey's post test) compared with 7 days. The TA presented higher values than the TN for BA and BIC at 14, 21, and 28 days after placement, stabilizing bone healing. TA hydrophilic surface promoted early osseointegration at 14 and 21 days compared to TN, accelerating bone healing period post-implant placement in sheep tibia.

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Early osseointegration to hydrophilic and hydrophobic implant surfaces in humans

Abstract: While healing showed similar characteristics with bone resorptive and appositional events for both SLActive and SLA surfaces between 7 and 42 days, the degree of osseointegration after 2 and 4 weeks was superior for the SLActive compared with the SLA surface.

Cited by 399 publications

References 22 publications

Titanium surface hydrophilicity enhances platelet activation

Titanium surface hydrophilicity enhances platelet activation

Bilateral sinus floor augmentation using 100% alloplastic biomaterial for later rehabilitation of atrophic maxilla. A 5-year tomographic follow-up

Accelerated Healing Period with Hydrophilic Implant Placed in Sheep Tibia

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