Early oxidative stress in amniotic fluid of pregnancies with Down syndrome

Perrone, Serafina; Longini, Mariangela; Bellieni, Carlo V.; Centini, Giovanni; Kenanidis, A.; Marco, L De; Petraglia, Felice; Buonocore, Giuseppe

doi:10.1016/j.clinbiochem.2006.10.019

Cited by 80 publications

(53 citation statements)

References 28 publications

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“…They suggested that up-regulation of the chromosome 21 gene S100B causes an increase in reactive oxygen species and stress-response kinases, leading to an increase in programmed cell death. Using a biochemical approach, other investigators demonstrated increased levels of isoprostanes, a marker of oxidative stress, in second trimester amniotic fluid samples from DS fetuses (31). Our study is the first functional analysis of the DS fetus that implicates not only oxidative stress, but potential intermediate consequences, such as defects in ion transport and G protein signaling.…”

Section: Discussionmentioning

confidence: 86%

Functional genomic analysis of amniotic fluid cell-free mRNA suggests that oxidative stress is significant in Down syndrome fetuses

Slonim

Koide

Johnson

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

112

143

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To characterize the differences between second trimester Down syndrome (DS) and euploid fetuses, we used Affymetrix microarrays to compare gene expression in uncultured amniotic fluid supernatant samples. Functional pathway analysis highlighted the importance of oxidative stress, ion transport, and G protein signaling in the DS fetuses. Further evidence supporting these results was derived by correlating the observed gene expression patterns to those of small molecule drugs via the Connectivity Map. Our results suggest that there are secondary adverse consequences of DS evident in the second trimester, leading to testable hypotheses about possible antenatal therapy for DS.antenatal therapy ͉ Connectivity Map ͉ gene expression ͉ prenatal diagnosis ͉ trisomy 21

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Section: Discussionmentioning

confidence: 86%

Functional genomic analysis of amniotic fluid cell-free mRNA suggests that oxidative stress is significant in Down syndrome fetuses

Slonim

Koide

Johnson

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

112

143

View full text Add to dashboard Cite

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“…The well-known mechanisms for the development of NTDs include folate deficiency, in utero drug exposure, and genetic susceptibility [2]. However, the exact pathogenesis of NTDs remains to be fully elucidated [3]. It has been reported that the direct relationship between antiepileptic drug therapy and the development of NTD is attributed to the formation of toxic drug metabolites and free radical damage [4].…”

Section: Introductionmentioning

confidence: 99%

“…Oxidative metabolism was reported to be related with congenital anomalies, including NTDs [3]. Free radicals or reactive oxygen species are generated during aerobic respiration and metabolism.…”

Section: Introductionmentioning

confidence: 99%

Relationship between maternal blood ceruloplasmin level, catalase and myeloperoxidase activity and neural tube defects

et al. 2017

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Objectives: The exact pathogenesis of neural tube defects (NTDs) is poorly understood. We aimed at evaluating maternal anti-oxidant capacity (ceruloplasmin level, myeloperoxidase and catalase activity) in pregnancies complicated by NTDs. Material and methods:Fifty-four mothers with NTD-affected pregnancies and 61 healthy mothers, matched for gestational age, were recruited. Maternal venous blood samples were obtained after detailed fetal ultrasound examination to measure myeloperoxidase, catalase activity and ceruloplasmin levels. The clinical characteristics of all participants were collected.Results: Maternal blood catalase activity was significantly lower in the study group (117.1 ± 64.8 kU/L) as compared to controls (152.2 ± 110.6 kU/L) (p = 0.044). Maternal blood ceruloplasmin levels were also significantly lower in the study group (180.5 ± 37.7 U/L) as compared to controls (197.9 ± 35.9 U/L) (p = 0.012). Myeloperoxidase activity was similar in both groups (112.6 ± 22.2 U/L vs. 113.6 ± 38.1 U/L) (p = 0.869). Conclusions:In the present study, maternal blood ceruloplasmin level and catalase activity were found to be lower in NTD-affected pregnancies as compared to healthy controls. Thus, it seems safe to conclude that impaired antioxidant capacity may play a role in the development of NTDs during pregnancy, in addition to the genetic, environmental and metabolic factors.

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“…At this point antioxidation mechanisms become an important activity of the organism in order to prevent biofunctional disorders. In the light of previous datas about the etiology of CNS anomalies, they seem to be related to oxidant chemical and physical agents (3)(4)(5)10). Ceruloplasmin was considered to be effective as an antioxidant in NTD.…”

Section: Discussionmentioning

confidence: 99%

“…The exact etiology of NTD is rather complex and poorly understood. Recently, oxidative metabolism was considered to be related with congenital anomalies including CNS (4,5).…”

Section: Introductionmentioning

confidence: 99%

The relationship of ceruloplasmin and neural tube defects

Yazıcıoğlu¹,

Cebesoy²,

Balat³

et al. 2010

J Turkish German Gynecol Assoc

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Objective:To compare the levels of ceruloplasmin (cp) in the amniotic fluids and maternal bloods of second trimester fetuses with and without neural tube defects (NTD). Materials and Methods:66 pregnant women were included in the study. Amniocentesis was performed in 32 women in a patient group diagnosed as NTD or anencephaly and 34 pregnants in a control group with positive Down Syndrome screening test. Maternal bloods were also taken. Cp was measured with Erel's ceruloplasmin measurement method. Results:The cp levels of the amniotic fluid of patients and controls were not statistically different (p>0.05). The cp levels of the maternal bloods were not different in two groups (p>0.05). Conclusion:As an antioxidant, no relation was found between cp and NTD. (J Turkish-German Gynecol Assoc 2010; 11: 86-8) Key words: Ceruloplasmin, Antioxidant, Neural tube defect Received: 5 February, 2010 Accepted: 24 March, 2010 Amaç: Bebeklerinde intrauterin nöral tüp defekti (NTD) olan ve olmayan ikinci trimesterdeki gebe kadınlarda amnion sıvısı ve anne kanın-daki seruloplasmin değerlerinin karşılaştırılması. Gereç ve Abstract ÖzetOriginal Investigation 86

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Early oxidative stress in amniotic fluid of pregnancies with Down syndrome

Cited by 80 publications

References 28 publications

Functional genomic analysis of amniotic fluid cell-free mRNA suggests that oxidative stress is significant in Down syndrome fetuses

Functional genomic analysis of amniotic fluid cell-free mRNA suggests that oxidative stress is significant in Down syndrome fetuses

Relationship between maternal blood ceruloplasmin level, catalase and myeloperoxidase activity and neural tube defects

The relationship of ceruloplasmin and neural tube defects

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