Projections of future climate depend critically on refined estimates of climate sensitivity. Recent progress in temperature proxies dramatically increases the magnitude of warming reconstructed from early Paleogene greenhouse climates and demands a close examination of the forcing and feedback mechanisms that maintained this warmth and the broad dynamic range that these paleoclimate records attest to. Here, we show that several complementary resolutions to these questions are possible in the context of model simulations using modern and early Paleogene configurations. We find that (i) changes in boundary conditions representative of slow "Earth system" feedbacks play an important role in maintaining elevated early Paleogene temperatures, (ii) radiative forcing by carbon dioxide deviates significantly from pure logarithmic behavior at concentrations relevant for simulation of the early Paleogene, and (iii) fast or "Charney" climate sensitivity in this model increases sharply as the climate warms. Thus, increased forcing and increased slow and fast sensitivity can all play a substantial role in maintaining early Paleogene warmth. This poses an equifinality problem: The same climate can be maintained by a different mix of these ingredients; however, at present, the mix cannot be constrained directly from climate proxy data. The implications of strongly state-dependent fast sensitivity reach far beyond the early Paleogene. The study of past warm climates may not narrow uncertainty in future climate projections in coming centuries because fast climate sensitivity may itself be state-dependent, but proxies and models are both consistent with significant increases in fast sensitivity with increasing temperature.superrotation | hyperthermal T he early Paleogene (∼65-35 Mya) was the most recent time when the atmospheric carbon dioxide (CO 2 ) concentration was in the ≥1,000-ppm range that may reoccur over the next several centuries (1). Study of this period may therefore provide constraints on climate sensitivity, broadly defined as the global mean temperature response to radiative forcing, which are useful for climate change prediction (2, 3). On the other hand, analogies between early Paleogene and future climates are not straightforward because so many other variables apart from CO 2 have also changed (4), and because climate sensitivity may change across different climate states (3,5). Given the crucial role that paleoclimate data from past greenhouse climates play in informing the debates about future climate change (6, 7), an investigation of the strengths and limitations of using such data to make inferences about climate sensitivity is in order.Recent progress in reconstructing the early Paleogene has brought an across-the-board upward revision of surface temperature estimates. Tropical sea surface temperatures (SSTs), previously thought to be similar to or even cooler than modern SSTs, were 3-10°C warmer than today (8-12), although uncertainty on these values remains large (13). Extratropical surface temperature...