2002
DOI: 10.4049/jimmunol.168.8.4050
|View full text |Cite
|
Sign up to set email alerts
|

Early Phase Bronchoconstriction in the Mouse Requires Allergen-Specific IgG

Abstract: Allergen provocation of allergic asthma patients is often characterized by an initial period of bronchoconstriction, or early phase reaction (EPR), that leads to maximal airway narrowing within 15–30 min, followed by a recovery period returning airway function to baseline within 1–2 h. In this study, we used a defined OVA provocation model and mice deficient for specific leukocyte populations to investigate the cellular/molecular origins of the EPR. OVA-sensitized/challenged wild-type (C57BL/6J) mice displayed… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

1
12
0
3

Year Published

2006
2006
2024
2024

Publication Types

Select...
5
3
2

Relationship

0
10

Authors

Journals

citations
Cited by 27 publications
(16 citation statements)
references
References 36 publications
1
12
0
3
Order By: Relevance
“…Platelet (PLT)-activating factor (PAF) may also contribute to the onset of the shock symptoms, because PAF released from basophils, and probably mast cells, has been reported to make PLTs coagulate and degranulate releasing inflammatory mediators including 5-hydroxytryptamine 14,15 . Furthermore, being consistent with reports that airway constriction is induced by the release of chemical mediators in anaphylaxis 16,17 , airway resistance increased in the mice of the present study after the 3 rd injection of OA, and this is considered comparable with the clinical signs of respiratory depression. In PCA tests, OA-specific IgE and IgG were detected in sera collected from mice just before the 3 rd injection.…”
Section: Discussionsupporting
confidence: 93%
“…Platelet (PLT)-activating factor (PAF) may also contribute to the onset of the shock symptoms, because PAF released from basophils, and probably mast cells, has been reported to make PLTs coagulate and degranulate releasing inflammatory mediators including 5-hydroxytryptamine 14,15 . Furthermore, being consistent with reports that airway constriction is induced by the release of chemical mediators in anaphylaxis 16,17 , airway resistance increased in the mice of the present study after the 3 rd injection of OA, and this is considered comparable with the clinical signs of respiratory depression. In PCA tests, OA-specific IgE and IgG were detected in sera collected from mice just before the 3 rd injection.…”
Section: Discussionsupporting
confidence: 93%
“…Experimental models of asthma in mice can also demonstrate early-and latephase airway responses to inhaled allergen and can be used to assess mechanisms and interventions (11,35). In the present study, we evaluated the role of the LTB4-BLT1 pathway in the development of allergen-induced EAR and LAR in previously sensitized and challenged mice after secondary allergen challenge.…”
Section: Discussionmentioning
confidence: 99%
“…However, none of these mediators plays a role in rats, where the allergen-induced bronchoconstriction is almost exclusively mediated by serotonin [8]. In the mouse, the mechanism of allergen-induced bronchoconstriction appears to be even more different, and apparently mast cell independent [33].…”
Section: Guinea Pig Precision-cut Lung Slicesmentioning
confidence: 99%