Early post‐natal development of the mandibular permanent first molar in infants with unilateral complete cleft lip and palate

Hermann, Nuno V.; Darvann, Tron A.; Kreiborg, Sven

doi:10.1111/ocr.12197

Cited by 3 publications

(10 citation statements)

References 25 publications

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“…This age variation reflects the treatment protocol, where the lip was closed stepwise in the groups with bilateral clefts to model the soft tissue. In the present study, like in previous studies by Hermann et al 22,23 the lateral cephalograms were used to assess tooth maturation inspired by Haavikko's method. 26 It should be noted that this procedure might introduce a possible error in case of asymmetric dental development.…”

Section: Methodsmentioning

confidence: 97%

“…The methods are the same as previously used in a study describing the early postnatal development of M1 inf in infants with CP and UCCLP. 22,23…”

Section: Methodsmentioning

confidence: 99%

“…The maturation/degree of mineralization of the crown was scored according to a method previously described by Hermann et al 22,23 Tooth maturation was scored using Haarvikko's maturation stages All distances were measured to the nearest 0.1 mm using a digital Vernier caliper, and all measurements and scores were obtained twice by the same observer (1 month apart) to estimate the error of the method.…”

Section: Variables For M1 Infmentioning

confidence: 99%

“…[18][19][20][21] We also found delay in mineralization of M1 inf in a previous study on infants and young children with isolated CP and UCCLP. 22,23 The delayed mineralization of the teeth observed in subjects with CP with/without a cleft lip might be related to the observed delay in somatic development (first observed as reduced body weight and later as reduced body length). 22,23 The delay in somatic development and in mineralization of the teeth is most likely caused by feeding difficulties in infants with clefts 24,25 and subsequent malnutrition or undernourishment.…”

Section: Maturation or Mineralization Stagementioning

confidence: 99%

“…A previous study analysed maturation and width of the dental follicle and crown of the permanent first mandibular molar (M1 inf ) from cephalometric radiographs in young children with isolated cleft palate (CP), and unilateral complete CLP (UCCLP), and found delayed M1 inf maturation and reduced crown width in both groups of patients. 22,23 To clarify if these findings are representative for all subtypes with CLP, this study aimed to assess maturation and width of the follicle and crown of M1 inf in a population-based large consecutive sample of infants and young children with different subtypes of CLP.…”

Section: Introductionmentioning

confidence: 99%

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Delayed maturation and reduced crown width of the permanent first mandibular molar in all subgroups of cleft lip and palate

Hermann

Darvann

Kreiborg

2020

Orthod Craniofacial Res

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Objectives: Surgical closure of the cleft damages nerves and blood supply in the area and may possibly negatively influence dental development in children with cleft lip and palate (CLP). Previous studies of the permanent first mandibular molar (M1 inf) in children with unilateral complete CLP found delayed maturation and decreased follicle/crown width before any surgical interventions. This study aimed to investigate if these findings are representative for the total population of individuals born with CLP. Setting and sample population: A population-based consecutive longitudinal sample of 224 children with clefts: 183 with CLP (66 with complete [47 unilateral, 19 bilateral], 117 with incomplete [70 unilateral, 47 bilateral], and 41 with unilateral incomplete cleft lip (controls), was examined pre-and post-lip closure (at 2 and 22 months of age). Material and methods: In lateral cephalometric X-rays (obtained as part of a standard treatment protocol), M1 inf follicle maturation and follicle/crown width were assessed. Mantel-Haenszel test and Pearson's correlation coefficient R were used to describe relationships. Differences between group means were tested using Wilcoxon rank sum test. Significance level was set to 5%. Results: Follicle maturation was significantly delayed in all groups with CLP compared to that in controls (P < .01). Follicle and crown width were significantly reduced in all CLP groups compared with those in controls (P < .01). Sex did not influence these variables. Conclusion: Delayed follicle maturation and decreased follicle/crown/tooth size were found to be part of the congenital traits characterizing individuals with all types of CLP and not a result of surgical iatrogenesis. K E Y W O R D S cleft lip and palate, follicle, M1 inf , odontogenesis, tooth | 433 HERMANN Et Al.

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Section: Methodsmentioning

confidence: 97%

“…The methods are the same as previously used in a study describing the early postnatal development of M1 inf in infants with CP and UCCLP. 22,23…”

Section: Methodsmentioning

confidence: 99%

Section: Variables For M1 Infmentioning

confidence: 99%

Section: Maturation or Mineralization Stagementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Delayed maturation and reduced crown width of the permanent first mandibular molar in all subgroups of cleft lip and palate

Hermann

Darvann

Kreiborg

2020

Orthod Craniofacial Res

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Deep orofacial phenotyping of population-based infants with isolated cleft lip and isolated cleft palate

Yow

Hermann

Yuan

et al. 2020

Sci Rep

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Isolated orofacial clefts (OFC) are common with poorly understood aetiology. Heterogeneous phenotypes and subphenotypes confound aetiological variant findings. To improve OFC phenome understanding, population-based, consecutive, pre-treatment infants with isolated unilateral cleft lip (UCL, n = 183) and isolated cleft palate (CP, n = 83) of similar ancestry were grouped for deep phenotyping. Subphenotypes stratified by gender and cleft severity were evaluated for primary dental malformations and maturation using radiographs. We found that cleft severity and tooth agenesis were inadequate to distinguish heterogeneity in infants with UCL and CP. Both groups featured slow dental maturity, significantly slower in males and the UCL phenotype. In 32.8% of infants with UCL, supernumerary maxillary lateral incisors were present on the cleft lip side, but not in infants with CP, suggesting a cleft dental epithelium and forme fruste cleft dentoalveolus of the UCL subphenotype. The findings underscored the importance of deep phenotyping to disclose occult OFC subphenotypes.

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Linear Difference Computed Tomography Size Large Molar Teeth in Healthy Men From Central Regions of Ukraine

Shinkaruk-Dykovytska

Kotsyura

Тепла

et al. 2018

WOMAB

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Early post‐natal development of the mandibular permanent first molar in infants with unilateral complete cleft lip and palate

Abstract: Maturation of the first mandibular molar is delayed in both genders, and FW and CW were reduced in UCCLP compared to controls. Maturation was correlated with FW.

Cited by 3 publications

References 25 publications

Delayed maturation and reduced crown width of the permanent first mandibular molar in all subgroups of cleft lip and palate

Delayed maturation and reduced crown width of the permanent first mandibular molar in all subgroups of cleft lip and palate

Deep orofacial phenotyping of population-based infants with isolated cleft lip and isolated cleft palate

Linear Difference Computed Tomography Size Large Molar Teeth in Healthy Men From Central Regions of Ukraine

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