Early post-surgical recurrence of metastatic vertebral neuro-endocrine tumour treated effectively with chemo-radiotherapy

Abstract

Spinal metastasis of neuro-endocrine tumours (NETs) usually arise from a primary in the lung. We encountered such a patient with NET metastasis to T6 vertebra causing severe cord compression. Considering the neurological status, immediate decompression surgery along with T3-T8 posterior stabilization was done. Early recurrence of the tumour causing near total obliteration of the spinal canal leading to significant neurological compromise was noted within one month of surgery. A second surgery at this stage was avoided due to the risk involved and concurrent chemo-radiotherapy was initiated. The tumour was sensitive to chemo-radiotherapy and rapid resolution was noted on subsequent follow-up visits. With appropriate rehabilitation, patient regained full power to become ambulant with support. This case report highlights a rare, early and aggressive recurrence of metastatic vertebral NET following index surgery which was effectively managed with chemo-radiotherapy.

Thoracic dumbbell spinal metastasis secondary to neuroendocrine tumor of unknown origin: Case report and literature review

“…[ 1 , 3 , 5 , 9 ] Neuroendocrine tumors are epithelial neoplasms originating mainly from the gastrointestinal or bronchopulmonary tracts; they frequently metastasize to lymph nodes, liver, lungs, and bone. [ 2 , 5 ] Here, a 34-year-old male presented with a T7-T9 metastatic neuroendocrine spinal dumbbell tumor of unknown primary origin that was successfully decompressed utilizing a laminectomy.…”