Early postmenopausal hormone therapy improves postural balance

Naessén, Tord; Lindmark, Birgitta; Lagerström, Christel; Larsen, H. C.; Persson, Ingemar

doi:10.1097/01.gme.0000248707.53075.7f

Cited by 37 publications

(24 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…For the female participants in the present study these fluctuations could be partly caused by changes in estrogen levels. In support of this notion, several studies have reported that postural balance was positively affected by increased levels of plasma estrogen [31][32][33]. In addition, estrogen secretion follows a diurnal pattern with elevated plasma levels in the morning that gradually decreases throughout the day [34].…”

Section: Subject Characteristicmentioning

confidence: 75%

Time-of-day influences postural balance in older adults

et al. 2012

View full text Add to dashboard Cite

Section: Subject Characteristicmentioning

confidence: 75%

Time-of-day influences postural balance in older adults

et al. 2012

View full text Add to dashboard Cite

“…After such age range, a gradual deterioration in performance was observed [24]. Increased postural oscillation was shown in women older than 55 years, which is consistent with the increased number of forearm fractures [25]. Vision is most often needed for postural stability maintenance, particularly among older persons [2].…”

Section: Discussionmentioning

confidence: 92%

Evaluation of postural balance in postmenopausal women and its relationship with bone mineral density- a cross sectional study

Cangussu

Nahás-Neto

Nahás

et al. 2012

BMC Musculoskelet Disord

View full text Add to dashboard Cite

BackgroundLow bone mineral density (BMD) and falls are common problems encountered in the postmenopausal women. The purpose was to evaluate the association between postural balance and BMD in postmenopausal women and its relation to risk for falls.MethodsIn this cross-sectional study, 225 women in amenorrhea > 12 months and age ≥ 45 years were included and divided, according to BMD, in T-score values > -2.0 SD (n = 140) and ≤ -2 SD (n = 85). Those with neurological or musculoskeletal disorders, history of vestibulopathies, uncorrected visual deficit or drug use that could affect balance were excluded. History of falls (last 24 months), clinical and anthropometric characteristics were evaluated. Postural balance was assessed by stabilometry (force platform). For statistical analysis were used Wilcoxon's Test, Chi-Square Test and logistic regression method for fall risk (Odds Ratio-OR).ResultsPatients with BMD > -2.0 SD were younger, with shorter time since menopause, and showed higher BMI as compared to those with low BMD (≤ -2 SD) (p < 0.05). It was observed that 57.8% of the participants reported fall episodes without significant difference distribution between the groups (p = 0.055). No differences were found from the comparison between the groups (p > 0.05) for stabilometric parameters. Risk for falls increased with age (OR 1.07; CI 95% 1.01-1.13), current smoking (OR 2.19; CI 95% 1.22-3.21) and corrected visual deficit (OR 9.06; CI 95% 1.14-4.09). In contrast, hormone therapy (HT) use was significantly associated with reduced risk for falls (OR 0.48; CI 95% 0.26-0.88).ConclusionsIn postmenopausal women, BMD did not show association with postural balance or risk for falls. Age, smoking and corrected visual deficit were clinical indicators of risk for falls whereas HT use showed to be a protective factor.

show abstract

“…However, the mean age (54.2 y) was substantially lower in the previous studies and the dose of tibolone used (2.5 mg/d) was higher, twice that used in our study. It seems to be easier to affect some outcomes if treatment is undertaken close to menopause, as previously described for postural balance function 11 and progression of atherosclerosis in the artery wall. 35,36 Proximity to menopause could therefore explain the positive effects of tibolone on muscle strength in the previous report.…”

Section: Discussionmentioning

confidence: 98%

“…7 Multiple-component group exercise regimens reduce the incidence of falls and the risk of falling, as do tai chi and individually prescribed multicomponent home-based exercise programs. 8 Postmenopausal hormone therapy (HT) increases bone mass, 9 improves postural balance, [10][11][12] and reduces fracture risk, 13 but the risk of fracture returns rapidly to baseline after stopping therapy. [14][15][16][17] Whether HT in older women can improve postural balance and/or muscle strength and function, and thus reduce the risk of falls and fracture, is a very important question because most fractures occur in older people.…”

mentioning

confidence: 99%

Low-dose tibolone (1.25 mg/d) does not affect muscle strength in older women

Ribom

Svensson

Os³

et al. 2011

Menopause

Self Cite

View full text Add to dashboard Cite

Objective: More than 50% of all fractures occur in people without osteoporosis. Hormone therapy increases bone density, improves postural balance, and reduces fracture risk in postmenopausal women. It is unclear whether tibolone, a synthetic steroid hormone drug, can improve muscle strength. Thus, the aim of this study was to study the effects of low-dose tibolone therapy on muscle strength in older women.Methods: Eighty healthy women (69 completed the study) 60 years or older were recruited through advertising in the local media. They were randomly allocated to receive either tibolone 1.25 mg/day or placebo for 6 months. The stand-up test was used to assess leg muscle strength and balance. Handgrip and leg muscle strength were measured using JAMAR and modified Cybex dynamometers.Results: Baseline characteristics, including serum estradiol values and muscle strength, were similar in the two groups. Compliance with the therapy regimen was very high, averaging more than 97% in both groups. After 6 months, mean values for handgrip strength, knee extensor strength, and average time to perform 10 stands were improved numerically in both groups compared with values during baseline. However, there were no significant differences in these parameters within or between groups, and differences remained nonsignificant after adjustment for age, serum estradiol, and baseline value.Conclusions: Short-term treatment with low-dose tibolone (1.25 mg/d) seems not to affect muscle strength in older women.

show abstract

Early postmenopausal hormone therapy improves postural balance

Cited by 37 publications

References 44 publications

Time-of-day influences postural balance in older adults

Time-of-day influences postural balance in older adults

Evaluation of postural balance in postmenopausal women and its relationship with bone mineral density- a cross sectional study

Low-dose tibolone (1.25 mg/d) does not affect muscle strength in older women

Contact Info

Product

Resources

About