Early postnatal exposure to endosulfan interferes with the normal development of the male rat mammary gland

Altamirano, Gabriela A.; Delconte, Melisa B.; Gómez, Ayelén L.; Alarcón, Ramiro; Bosquiazzo, Verónica L.; Luque, Enrique H.; Muñoz-de-Toro, Mónica; Kass, Laura

doi:10.1016/j.toxlet.2017.09.012

Cited by 17 publications

(9 citation statements)

References 41 publications

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“…Nonetheless, a small number of mammalian (mostly rat) studies on endosulfan exist providing valuable information pertaining to human health. Exposure to endosulfan in young male rats interferes with normal development of the mammary glands [87], an expected result for EDC toxicity. Recent work has also linked endosulfan exposure to deficiencies in the brain and behavioral functions [88].…”

Section: Endosulfan: Pesticidementioning

confidence: 96%

Potential Health Risks Linked to Emerging Contaminants in Major Rivers and Treated Waters

Kessler

Dawley

Crow

et al. 2019

Water

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The presence of endocrine-disrupting chemicals (EDCs) in our local waterways is becoming an increasing threat to the surrounding population. These compounds and their degradation products (found in pesticides, herbicides, and plastic waste) are known to interfere with a range of biological functions from reproduction to differentiation. To better understand these effects, we used an in silico ontological pathway analysis to identify the genes affected by the most commonly detected EDCs in large river water supplies, which we grouped together based on four common functions: Organismal injuries, cell death, cancer, and behavior. In addition to EDCs, we included the opioid buprenorphine in our study, as this similar ecological threat has become increasingly detected in river water supplies. Through the identification of the pleiotropic biological effects associated with both the acute and chronic exposure to EDCs and opioids in local water supplies, our results highlight a serious health threat worthy of additional investigations with a potential emphasis on the effects linked to increased DNA damage.

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Section: Endosulfan: Pesticidementioning

confidence: 96%

Potential Health Risks Linked to Emerging Contaminants in Major Rivers and Treated Waters

Kessler

Dawley

Crow

et al. 2019

Water

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“…The E2 and T levels were determined by chemiluminescence assays using an Immulite® 2000 system (Siemens Healthcare SA, Argentina), following the manufacturer's specifications. The assays had a detection limit of 15 pg/ml for E2 and of 0.15 ng/ml for T. The intra-assay coefficient of variation for E2 was 6.7%, whereas that for T was 10.1% (Altamirano et al, 2017).…”

Section: E2 and T Levels Serum Levelsmentioning

confidence: 99%

“…As previously described (Altamirano et al, 2017), images of mammary gland wholemounts from PND21 were recorded using a Spot Insight V3.5 color video camera attached to a Stemi 305 stereomicroscope (ZEISS, Argentina), whereas those from PND60 were recorded using a Sony Alpha a58 DSLR Camera (Sony Latin America, Inc.). All images were analyzed with ImageJ software (NIH, USA; https://imagej.nih.gov/ij).…”

Section: Mammary Gland Whole-mount Evaluationmentioning

confidence: 99%

“…All evaluations were carried out blinded to the treatment group on mammary gland N°4. Different mammary gland parameters, including total area, perimeter, distance between mammary glands N°4 and 5, longitudinal growth and number of terminal end buds (TEBs), were analyzed on mammary gland whole-mount images (Altamirano et al, 2017;Kass et al, 2015).…”

Section: Mammary Gland Whole-mount Evaluationmentioning

confidence: 99%

“…The male mammary gland of rats has been used by several researchers as a useful model to study the effects of potential endocrine disruptors that may affect the risk of breast cancer in humans (Filgo et al, 2016;Mandrup et al, 2016;Mandrup et al, 2015). Recently, we showed that prenatal exposure to the endocrine disruptor bisphenol A induces a growth delay and decreases the expression of androgen receptor (AR) in the pre-pubertal male rat mammary gland (Kass et al, 2015) and that early postnatal exposure to endosulfan induces premalignant lesions in the mammary gland of post-pubertal male rats (Altamirano et al, 2017). There is evidence that chronic exposure to GBH increases mammary tumor incidence in adults rats (Seralini et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

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Postnatal exposure to a glyphosate-based herbicide modifies mammary gland growth and development in Wistar male rats

Altamirano

Delconte

Gómez

et al. 2018

Food and Chemical Toxicology

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Our aim was to evaluate whether postnatal exposure to a glyphosate-based herbicide (GBH) modifies mammary gland development in pre- and post-pubertal male rats. From postnatal day 1 (PND1) to PND7, male rats were injected subcutaneously every 48 h with either saline solution (vehicle) or 2 mg GBH/kg·bw. On PND21 and PND60, mammary gland and blood samples were collected. Estradiol (E2) and testosterone (T) serum levels, mammary gland histology, collagen fiber organization, mast cell infiltration, proliferation index, and estrogen (ESR1) and androgen receptor (AR) expression levels were evaluated. At PND21, GBH-exposed male rats exhibited greater development of the mammary gland with increased stromal collagen organization and terminal end buds (TEBs) compared to control rats. At PND60, the number of TEBs remained high and was accompanied by an increase in mast cell infiltration, proliferation and ESR1 expression in GBH-exposed male rats. In contrast, no effects were observed in E2 and T serum levels and AR expression in both days studied. Our results showed that a postnatal subacute treatment with GBH induces endocrine-disrupting effects in the male mammary gland in vivo, altering its normal development.

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Exposure to atrazine and endosulfan alters oviductal adenogenesis in the broad-snouted caiman (Caiman latirostris)

Tavalieri,

Alarcón,

Tschopp

et al. 2024

Environ Sci Pollut Res

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Early postnatal exposure to endosulfan interferes with the normal development of the male rat mammary gland

Cited by 17 publications

References 41 publications

Potential Health Risks Linked to Emerging Contaminants in Major Rivers and Treated Waters

Potential Health Risks Linked to Emerging Contaminants in Major Rivers and Treated Waters

Postnatal exposure to a glyphosate-based herbicide modifies mammary gland growth and development in Wistar male rats

Exposure to atrazine and endosulfan alters oviductal adenogenesis in the broad-snouted caiman (Caiman latirostris)

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