2015
DOI: 10.1016/j.bbi.2015.05.001
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Early postnatal respiratory viral infection induces structural and neurochemical changes in the neonatal piglet brain

Abstract: Infections that cause inflammation during the postnatal period are common, yet little is known about their impact on brain development in gyrencephalic species. To address this issue, we investigated brain development in domestic piglets which have brain growth and morphology similar to human infants, after experimentally infecting them with porcine reproductive and respiratory syndrome virus (PRRSV) to induce an interstitial pneumonia Piglets were inoculated with PRRSV on postnatal day (PD) 7 and magnetic res… Show more

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Cited by 5 publications
(3 citation statements)
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“…As a result, a severe reduction in growth during the first seven to ten days post-weaning is observed [ 2 , 19 , 20 ]. While detrimental during the weaning period, evidence suggests that the physiological effects of weaning also lead to lifelong impairments in gut health, as well as sensitivity to stress and immune challenges [ 8 , 9 , 21 , 22 ]. Moreover, the period of growth immediately following weaning directly impacts how fast pigs reach market weight [ 5 , 6 ].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…As a result, a severe reduction in growth during the first seven to ten days post-weaning is observed [ 2 , 19 , 20 ]. While detrimental during the weaning period, evidence suggests that the physiological effects of weaning also lead to lifelong impairments in gut health, as well as sensitivity to stress and immune challenges [ 8 , 9 , 21 , 22 ]. Moreover, the period of growth immediately following weaning directly impacts how fast pigs reach market weight [ 5 , 6 ].…”
Section: Discussionmentioning
confidence: 99%
“…This period of growth is of particular importance because it can negatively affect the lifelong productivity of pigs [ 5 , 6 , 7 ]. Furthermore, evidence suggests that inflammation and gut dysfunction during early weaning results in lifelong hyper-reactivity to stress and immune challenges [ 8 , 9 ]. Recently, antibiotics have been fed during early weaning to promote gut health and reduce inflammation [ 10 , 11 ].…”
Section: Introductionmentioning
confidence: 99%
“…previously described by Radlowski et al (19) and Conrad et al (15,20). Clusters consisting of <20 edge-connected clusters were not considered for analysis.…”
Section: Methodsmentioning
confidence: 99%