Early potential metabolic biomarkers of primary postpartum haemorrhage based on serum metabolomics

Abstract

Objectives: Postpartum hemorrhage (PPH) is the leading cause of maternal death, accounting for 1/4 of maternal deaths worldwide. Determining sensitive biomarkers in the peripheral blood to identify postpartum haemorrhage (PPH) is essential for the early diagnosis and management of PPH. The purpose of this study is to identify predictive serum metabolic biomarkers of PPH. Thirty healthy pregnant women and 30 cases of postpartum hemorrhage were studied for our research. Material and methods: The serum metabolites of all pregnant were detected by liquid chromatography-quadruple time-of-flight mass spectrometry (LC-QTOFMS) and the corresponding biomarkers were identified. Results: 34 significantly altered metabolites in PPH-pre-group were identified. They were mainly involved in fatty acid, and glycerophospholipid metabolism. Conclusions: The LysoPCs, PCs, PGs, PIs were effective biomarkers for identifying PPH. The disturbed signaling pathways, mTOR signaling, acute phase response signaling, AMPK signaling and eNOS signaling pathways might be related to the etiopathogenesis of PPH. Our study provided a valuable attempt to screen early diagnostic markers of PPH and to further understand its pathogenesis.

Effect of Baogong Zhixue Granules Combined with Tranexamic Acid Injection on the Hemodynamics and Reproductive System in Patients with Postpartum Hemorrhage after Cesarean Section

“…Postpartum hemorrhage (PPH), a common complication of cesarean section, is mainly caused by maternal physical weakness, emotional tension, and injuries of the uterine muscle wall, adding to the risk of perioperative maternal deaths if no timely and effective treatment is taken for puerperae. With the continuous development of medicine, drugs for preventing PPH after cesarean section are gradually diversified [ 17 , 18 ]. Fahrenholtz et al [ 19 ] reported that PPH mostly occurs within 2 hours after delivery and uterine atony bleeding accounts for more than 70%, so uterotonic drugs are mainly used for postpartum treatment in clinic.…”

Modern Technology to Diagnose Early Postpartum Hemorrhage in Island Areas : A Systematic Review

“…The study can also predict postpartum hemorrhage. This research provides meaningful efforts to screen the indicators of early postpartum diagnosis and to understand the pathogenic characteristics [17].…”