Early prediction of local control in head and neck cancer after chemoradiotherapy by FDG-PET

Hoshikawa, Hiroshi; Kishino, Takehito; Nishiyama, Yoshihiro; Yamamoto, Yuka; Yonezaki, Masafumi; Mori, Nozomu

doi:10.1097/mnm.0b013e328346f02c

Cited by 11 publications

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“…Several authors have suggested 10-12 wk after the end of treatment (29)(30)(31)(32), but others showed that negative PET findings accurately determined a complete response to therapy within 8 wk (33)(34)(35). Previously, we examined the usefulness of early posttreatment 18 F-FDG PET for assessing local control quantitatively and qualitatively (36). We found the combined analysis of posttreatment SUV and percentage change in SUV to be useful for predicting the therapeutic responses of metastatic lymph nodes.…”

Section: Discussionmentioning

confidence: 97%

Usefulness of 3′-Deoxy-3′-¹⁸F-Fluorothymidine PET for Predicting Early Response to Chemoradiotherapy in Head and Neck Cancer

et al. 2012

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This study compared the utility of 39-deoxy-39-18 F-fluorothymidine PET ( 18 F-FLT PET) with that of 18 F-FDG PET for assessment of the early locoregional clinical outcomes of chemoradiotherapy for head and neck squamous cell carcinomas. Methods: From May 2006 to September 2010, 28 patients with head and neck squamous cell carcinomas underwent 18 F-FLT and 18 F-FDG PET before radiation therapy (RT), 4 wk after the initiation of RT, and 5 wk after completion of RT. PET images were evaluated qualitatively for regions of focally increased metabolism and were analyzed in relation to residual accumulation and local disease control. Results: During RT, 18 F-FLT uptake decreased more significantly than 18 F-FDG uptake. 18 F-FLT accumulations disappeared in 34 of 54 lesions (63%), and negative predictive value was 97%. 18 F-FDG PET during RT also had a high negative predictive value (100%), but only 9 lesions (16%) showed complete absence of accumulation. The specificity and overall accuracy of 18 F-FLT PET were significantly higher than those of 18 F-FDG PET both during and after RT. In particular, high significance was attributable to the results of the evaluations of primary lesions. There were significant differences in 3-y local control between the residual-accumulation and no-accumulation groups on both posttreatment 18 F-FLT PET (P , 0.0001) and posttreatment 18 F-FDG PET (P 5 0.0081). Conclusion: 18 F-FLT PET during RT and early follow-up facilitates the selection of optimal further therapy and the prediction of outcomes.

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Section: Discussionmentioning

confidence: 97%

Usefulness of 3′-Deoxy-3′-¹⁸F-Fluorothymidine PET for Predicting Early Response to Chemoradiotherapy in Head and Neck Cancer

et al. 2012

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“…All these studies evaluated the SUVMax. A high SUVMax in post treatment was correlated with a poor outcome in 6 studies (Horiuchi et al, 2008;Hoshikawa et al, 2011;Ito et al, 2014;Kim et al, 2016;Kitagawa et al, 2003;Moeller et al, 2010). In (Moeller et al, 2010), 98 patients underwent a PET before and 8 weeks after RT +/− CT.…”

Section: Predictive Value Of 18fdg Pet After Treatmentmentioning

confidence: 99%

Overview of the predictive value of quantitative 18 FDG PET in head and neck cancer treated with chemoradiotherapy

Castelli

Bari

Depeursinge

et al. 2016

Critical Reviews in Oncology/Hematology

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International audience18 F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) allows to quantify the metabolic activity of a tumor (glycolysis) and has become a reference tool in oncology for the staging, restaging, radiotherapy planning and monitoring response in many cancers. Quantitative analyses have been introduced in order to overcome some of the limits of the visual methods, allowing an easier and more objective comparison of the inter- and intra-patients variations. The aims of this review were to report available evidences on the clinical value of quantitative PET/CT parameters in HNC. Forty-five studies, for a total of 2928 patients, were analyzed. Most of the data available dealt with the intensity of the metabolism, calculated from the Standard Uptake Value (SUV). Metabolic Tumor Volume (MTV) was well correlated with overall survival and disease free survival, with a higher predictive value than the maximum SUV. Spatial distribution of metabolism and textural analyses seems promising

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“…Responses to chemoradiotherapy were evaluated by CT and PET findings 4-6 weeks after the end of therapy. As a result, residual metastatic lymph nodes were suspected morphologically and by PET findings [20], those patients underwent neck dissection within 2-3 weeks after the imaging evaluation.…”

Section: Patientsmentioning

confidence: 99%

Comparison of¹⁸F-FLT PET and¹⁸F-FDG PET for detection of cervical lymph node metastases in head and neck cancers

Hoshikawa¹,

Kishino²,

Mori³

et al. 2012

Acta Oto-Laryngologica

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The mean (± SD) FLT SUV in visualized metastatic lymph nodes was 4.8 ± 2.9 as compared with 6.9 ± 4.9 for FDG SUV (p < 0.001). Significant correlations were found between the area of metastatic lymph nodes and both FLT SUV (r = 0.8; p < 0.0001) and FDG SUV (r = 0.84; p < 0.0001). The false-positive (over-staged) and false-negative (under-staged) rates for lymph node staging by FLT PET were 4% (1/23) and 17% (4/23), respectively. Those for FDG PET were 9% (2/23) and 13% (3/23). All metastatic lymph nodes measuring more than 9 mm in short-axis diameter were correctly detected by FLT PET. However, both FLT and FDG PET had low sensitivity for detecting the lymph node metastases ≤ 9 mm in short-axis diameter and tumor deposits < 5 mm.

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Early prediction of local control in head and neck cancer after chemoradiotherapy by FDG-PET

Abstract: Early follow-up with FDG-PET is thus considered helpful further in choosing optimal therapy and for making an accurate prognosis.

Cited by 11 publications

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Usefulness of 3′-Deoxy-3′-¹⁸F-Fluorothymidine PET for Predicting Early Response to Chemoradiotherapy in Head and Neck Cancer

Usefulness of 3′-Deoxy-3′-¹⁸F-Fluorothymidine PET for Predicting Early Response to Chemoradiotherapy in Head and Neck Cancer

Overview of the predictive value of quantitative 18 FDG PET in head and neck cancer treated with chemoradiotherapy

Comparison of¹⁸F-FLT PET and¹⁸F-FDG PET for detection of cervical lymph node metastases in head and neck cancers

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Early prediction of local control in head and neck cancer after chemoradiotherapy by FDG-PET

Abstract: Early follow-up with FDG-PET is thus considered helpful further in choosing optimal therapy and for making an accurate prognosis.

Cited by 11 publications

References 0 publications

Usefulness of 3′-Deoxy-3′-18F-Fluorothymidine PET for Predicting Early Response to Chemoradiotherapy in Head and Neck Cancer

Usefulness of 3′-Deoxy-3′-18F-Fluorothymidine PET for Predicting Early Response to Chemoradiotherapy in Head and Neck Cancer

Overview of the predictive value of quantitative 18 FDG PET in head and neck cancer treated with chemoradiotherapy

Comparison of18F-FLT PET and18F-FDG PET for detection of cervical lymph node metastases in head and neck cancers

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Usefulness of 3′-Deoxy-3′-¹⁸F-Fluorothymidine PET for Predicting Early Response to Chemoradiotherapy in Head and Neck Cancer

Usefulness of 3′-Deoxy-3′-¹⁸F-Fluorothymidine PET for Predicting Early Response to Chemoradiotherapy in Head and Neck Cancer

Comparison of¹⁸F-FLT PET and¹⁸F-FDG PET for detection of cervical lymph node metastases in head and neck cancers