Early Predictors of Gestational Diabetes Mellitus in IVF-Conceived Pregnancies

Coussa, Ayla; Hasan, Hayder; Barber, Thomas M.

doi:10.1016/j.eprac.2020.10.020

Cited by 12 publications

(5 citation statements)

References 40 publications

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“…This is consistent with the finding that there is a higher risk for GDM in BMI‐matched and nonobese populations with PCOS 10 . Excessive early gestational weight gain has also been reported to be associated with a higher risk of developing GDM 46,47 . In a large unselected population of women with and without PCOS, the risk of GDM was similar where women with PCOS had a higher BMI at week 15 of pregnancy but similar early gestational weight gain 19 .…”

Section: Pcos Pregnancy and Birth Complicationssupporting

confidence: 86%

“…10 Excessive early gestational weight gain has also been reported to be associated with a higher risk of developing GDM. 46,47 In a large unselected population of women with and without PCOS, the risk of GDM was similar where women with PCOS had a higher BMI at week 15 of pregnancy but similar early gestational weight gain. 19 Studies reporting GDM in women with and without PCOS do not often report abdominal obesity and insulin resistance status at preconception or at early pregnancy 10 as risk factors for GDM.…”

Section: Pcos Pregnancy and Birth Complicationsmentioning

confidence: 99%

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Clinical management of pregnancy in women with polycystic ovary syndrome: An expert opinion

Khomami

Teede

Joham

et al. 2022

Clinical Endocrinology

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Polycystic ovary syndrome (PCOS) is associated with a higher risk for pregnancy and birth complications according to the specific features associated with PCOS.The features include obesity before and during pregnancy, hyperandrogenism, insulin resistance, infertility, cardiometabolic risk factors, and poor mental health.PCOS is not often recognized as a risk factor for poor pregnancy and birth outcomes in pregnancy care guidelines, while its associated features are. Pregnancy-related risk profile should ideally be assessed for modifiable risk factors (e.g., lifestyle and weight management) at preconception in women with PCOS. Hyperglycaemia should be screened using a 75-g oral glucose tolerance test at preconception or within the first 20 weeks of pregnancy if it has not been performed at preconception and should be repeated at 24-28 weeks of pregnancy. In the absence of evidence of benefit for strategies specific to women with PCOS, the international evidencebased guidelines for the assessment and management of PCOS recommend screening, optimizing, and monitoring risk profile in women with PCOS (at preconception, during and postpregnancy) consistent with the recommendations for the general population. Recommended factors include blood glucose, weight, blood pressure, smoking, alcohol, diet, exercise, sleep and mental health, emotional, and sexual health among women with PCOS. The guidelines recommend Metformin in addition to lifestyle for assisting with weight management and improving cardiometabolic risk factors, particularly in those with overweight or obesity.

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Section: Pcos Pregnancy and Birth Complicationssupporting

confidence: 86%

Section: Pcos Pregnancy and Birth Complicationsmentioning

confidence: 99%

Clinical management of pregnancy in women with polycystic ovary syndrome: An expert opinion

Khomami

Teede

Joham

et al. 2022

Clinical Endocrinology

View full text Add to dashboard Cite

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“…In comparison to the normal control group, pregnant women with PCOS are more prone to excessive weight gain during both early pregnancy and throughout the entire pregnancy. This heightened weight gain contributes to an increased risk of GDM ( 26 ). Findings from a community-based longitudinal study tracking the body mass index (BMI) trajectory in women of reproductive age indicate that both BMI and PCOS are linked to an elevated prevalence of GDM.…”

Section: Introductionmentioning

confidence: 99%

Investigating the causal impact of polycystic ovary syndrome on gestational diabetes mellitus: a two-sample Mendelian randomization study

Guixue,

Yifu,

Xiaofeng

et al. 2024

Front. Endocrinol.

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IntroductionDetermining the causal relationship between polycystic ovary syndrome (PCOS) and gestational diabetes mellitus (GDM) holds significant implications for GDM prevention and treatment. Despite numerous observational studies suggesting an association between PCOS and GDM, it remains unclear whether a definitive causal relationship exists between these two conditions and which specific features of PCOS contribute to increased incidence of GDM.MethodsThe causal relationship between polycystic ovary syndrome (PCOS), its characteristic indices, and gestational diabetes mellitus (GDM) was investigated using a two-sample Mendelian randomization study based on publicly available statistics from genome-wide association studies (GWAS). The inverse-variance weighted method was employed as the primary analytical approach to examine the association between PCOS, its characteristic indices, and GDM. MR Egger intercept was used to assess pleiotropy, while Q values and their corresponding P values were utilized to evaluate heterogeneity. It is important to note that this study adopts a two-sample MR design where PCOS and its characteristic indices are considered as exposures, while GDM is treated as an outcome.ResultsThe study results indicate that there is no causal relationship between PCOS and GDM (all methods P > 0.05, 95% CI of OR values passed 1). The IVW OR value was 1.007 with a 95% CI of 0.906 to 1.119 and a P value of 0.904. Moreover, the MR Egger Q value was 8.141 with a P value of 0.701, while the IVW Q value was also 8.141 with a P value of 0.774, indicating no significant heterogeneity. Additionally, the MR Egger intercept was 0.0004, which was close to zero with a P value of 0.988, suggesting no pleiotropy. However, the study did find a causal relationship between several other factors such as testosterone, high-density lipoprotein, sex hormone-binding globulin, body mass index, waist-hip ratio, apolipoprotein A-I, number of children, diabetes illnesses of mother, father and siblings, hemoglobin A1c, fasting insulin, fasting blood glucose, years of schooling, and GDM based on the IVW method.ConclusionWe observed no association between genetically predicted PCOS and the risk of GDM, implying that PCOS itself does not confer an increased susceptibility to GDM. The presence of other PCOS-related factors such as testosterone, high-density lipoprotein, and sex hormone-binding globulin may elucidate the link between PCOS and GDM. Based on these findings, efforts aimed at preventing GDM in individuals with PCOS should prioritize those exhibiting high-risk features rather than encompassing all women with PCOS.

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“… 11 IVF is a risk factor for adverse maternal outcomes, (such as gestational diabetes, gestational hypertension, and severe maternal morbidity, [SMM] eg, eclampsia), and fetal/infant adverse outcomes (such as congenital anomalies, preterm birth, and perinatal death). 12 , 13 , 14 , 15 , 16 …”

Section: Introductionmentioning

confidence: 99%

Racial/ethnic disparity in severe maternal morbidity among women who conceived by in vitro fertilization

Victory,

John,

Wang

et al. 2024

AJOG Global Reports

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Early Predictors of Gestational Diabetes Mellitus in IVF-Conceived Pregnancies

Cited by 12 publications

References 40 publications

Clinical management of pregnancy in women with polycystic ovary syndrome: An expert opinion

Clinical management of pregnancy in women with polycystic ovary syndrome: An expert opinion

Investigating the causal impact of polycystic ovary syndrome on gestational diabetes mellitus: a two-sample Mendelian randomization study

Racial/ethnic disparity in severe maternal morbidity among women who conceived by in vitro fertilization

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