Early predictors of myocardial disease in children and adolescents with type 1 diabetes mellitus

Salem, Mona A.; Behery, Soha El; Adly, Amira Abdel Moneam; Khalil, Dina Mahmoud; El-Hadidi, Eman S

doi:10.1111/j.1399-5448.2009.00517.x

Cited by 66 publications

(64 citation statements)

References 38 publications

(53 reference statements)

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“…Such comorbidities may be considered nonexistent in our cohort of diabetic children, who represent a unique model to investigate the early effects of metabolic disturbances induced by type 1 diabetes on myocardial function. Our results are not consistent with the previous studies reported by Salem et al and Khattab where the LV longitudinal function analyzed by TDI was preserved in children and adolescents with type 1 diabetes [10,27] . However, these authors analyzed the velocities of displacement of myocardial walls using pulsed TDI modality, which are more influenced by translational cardiac movements and displacement of adjacent myocardial segments [28] .…”

Section: Left Ventricular Morphology and Functioncontrasting

confidence: 56%

“…Overall, 30 consecutive children and adolescents with type 1 diabetes (age range [5][6][7][8][9][10][11][12][13][14][15][16][17] years, male: 53%) were recruited at our pediatric endocrinology department and enrolled in this prospective cohort. Among children with diabetes, HBA 1c ranged from 6.8% to 12.7% , 63% of the patients with diabetes patients had HBA 1C > 8 % and mean diabetes duration was 5.1 ± 3.1 years.…”

Section: Populationmentioning

confidence: 99%

“…The relationship between type 1 diabetes and cardiac structure and function in children and adolescents was poorly documented. Most of the previous echocardiographic studies have used standard techniques relatively insensitive to the detection of early myocardial dysfunction [9,10] . Strain and strain rate, derived from tissue Doppler imaging (TDI), have been proposed as parameters for the early detection of myocardial dysfunction [11] .…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Decreased regional left ventricular myocardial strain in type 1 diabetic children: a first sign of diabetic cardiomyopathy?

Hodžić

Ribault

Maragnès

et al. 2016

Journal of Translational Internal Medicine

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Background and Objectives: Type 1 diabetes is a major cardiovascular risk factor associated with an excess of mortality in young adults due to premature cardiovascular events, which includes heart failure. The relation between type 1 diabetes and cardiac structure and function in children was poorly documented. Our study investigates (1) whether type 1 diabetic children have echocardiographic signs of subclinical cardiac dysfunction assessed by tissue Doppler strain and (2) whether state of metabolic control and diabetes duration have any influence on the cardiac event. Methods: Standard echocardiography and tissue Doppler imaging were prospectively performed in type 1 diabetic children. Left ventricular dimensions, standard indices of systolic and diastolic function, and septal longitudinal strain were investigated. Results: Thirty consecutive asymptomatic diabetic children (age: 12.4 [5-17] years; males: 53%) were compared to 30 age and sex-matched healthy control subjects. Left ventricular mass index and diastolic septal thickness were significantly increased in diabetic children. There was no difference between two groups as regards the left ventricular ejection fraction and conventional mitral Doppler parameters (E, A, Ea). The global longitudinal systolic strain and strain rate were found to be decreased in children with diabetes. The global longitudinal early diastolic strain rate (Esr) was negatively correlated with metabolic control. Longitudinal strain was not correlated with diabetes duration. Conclusion: Children with Type 1 diabetes had subclinical alterations in left ventricular size and longitudinal myocardial deformation.

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Section: Left Ventricular Morphology and Functioncontrasting

confidence: 56%

Section: Populationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Decreased regional left ventricular myocardial strain in type 1 diabetic children: a first sign of diabetic cardiomyopathy?

Hodžić

Ribault

Maragnès

et al. 2016

Journal of Translational Internal Medicine

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“…Abnormal ambulatory BP patterns were also associated with higher left ventricular mass in youth with T1DM. 85 Diastolic dysfunction is also common in T1DM, 86 especially in youth with microvascular disease (microalbuminuria or retinopathy), 87 with a prevalence as high as 25% 88 correlated with glucose control. 89 Cardiac mass has also been found to be higher in adolescents with T2DM compared with control subjects 90 with concomitant abnormalities with diastolic filling.…”

mentioning

confidence: 99%

Cardiovascular Disease Risk Factors in Youth With Diabetes Mellitus

Maahs¹,

Daniels²,

Ferranti³

et al. 2014

Circulation

162

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“…Intensive glycemic control improves the cardiac autonomic nerve functions (14). However, measurements of QTc interval are easily obtained without the need for patient compliance, and QTc analysis is a simple, inexpensive, and noninvasive test that could be used to stratify the death risk in diabetic patients (25).…”

Section: Discussionmentioning

confidence: 99%

Natural progression of cardiac autonomic neuropathy in patients with type 1 diabetes: a four-year follow-up study

Dayem¹,

Battah²,

Soliman³

2011

Anadolu Kardiyol Derg

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ÖZETAmaç: Kardiyak otonom nöropatinin doğal seyrine daha fazla ışık tutmak için 4 yıl boyunca takip edilen Tip 1 diyabet hastalarında kardiyak otonom nöropati sıklığı ve klinik özelliklerini belirlemek. Yöntemler: Ewing ve Clarke (1985) tarafından önerilen standart testler kullanılarak, ilk olarak çalışılan 57 hastadan oluşan kohort gözlemsel ileriye dönük bir çalışmadır. İki yıllık takipte, 46 hasta yeniden değerlendirildi. Sonraki diğer bir 2 yılda üçüncü kez aynı protokol kullanılarak: Asıl çalışma-dan 55 hasta tekrar değerlendirildi. Kontrol grubu, aynı yaş ve cinsiyette 30 sağlıklı gönüllüden oluşmaktadır. İstatistiksel analizler McNemar testi, tekrarlanan ölçümler için ANOVA, eşleştirilmiş ve eşleştirilmemiş t-testleri ile yapılmıştır. Bulgular: Başlangıçta, kardiyak otonom noröpati (KON) saptanma sıklığı %14'tür. İkinci muayenede Q-Tc aralığı, anormal kardiyovasküler refleksi (CVRs) olan hastalarda anlamlı şekilde daha yüksek bulunmuştur (0.4±0.04 karşın 0.5±0.05 sn, p=0.006). Birinci ve üçüncü muayene arasında on sekiz hasta CVRs testinde bozulma gösterdi. Glikozile hemoglobin rehberliğinde, (8.5±1.4 karşın 9.9±1.5%, p=0.05) glisemik kontrollerinde ve albümin kreatinin oranında (4.4±4.0 karşın 28.2±28.0 mg/g kreatinin , p=0.04) bozulma vardır. Diğer yandan, 12 hasta CVRs testinde gerileme gösterdi. Sadece insülin dozunda anlamlı şekilde azalma oldu (1.8±1.3 karşın 1.1±0.3 doz/kg, p=0.02). Sonuç: Çalışmanın başlangıcında, diyabetik hastalarda saptanan KON sıklığı yüksektir. Kardiyak otonom nöropatilerinde bozulma olan diyabet hastalarında, glikozile hemoglobin, sistolik ve diyastolik kan basıncı anlamlı olarak yükseldi. Ancak, kardiyak otonom nöropatilerinde gerileme olan diyabet hastalarında insülin dozu anlamlı olarak azaldı. (Anadolu Kardiyol Derg 2011; 11: 224-31) Anahtar kelimeler: Kardiyak otonom nöropati, tip 1 diyabet, komplikasyon, doğal seyir ABSTRACT Objective: To determine the prevalence and clinical characteristics of cardiac autonomic neuropathy in type 1 diabetic patients who were followed up for 4 years to shed further light on the natural progression of cardiac autonomic neuropathy. Methods: It is a prospective cohort observational study, consisted of 57 patients who were originally studied using the standard tests proposed by Ewing and Clarke (1985). At two years follow up, 46 patients were reevaluated, 55 patients from the original study were reevaluated after another 2 years for the 3 rd time using the same protocol. The control group comprised 30 age and sex matched healthy volunteers. McNemar test, ANOVA for repeated measurements, paired t test and unpaired t test were used for statistical analyses. Results: The prevalence of established cardiac autonomic neuropathy (CAN) at the beginning was 14%. Q-Tc intervals were found to be significantly higher in patients with abnormal cardiovascular reflex (CVRs) in the 2nd examination (0.4±0.04 vs 0.5±0.05 sec, p=0.006). Eighteen patients showed deterioration of their CVRs test between 1st and 3rd examination. There was deterioration of their...

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Early predictors of myocardial disease in children and adolescents with type 1 diabetes mellitus

Cited by 66 publications

References 38 publications

Decreased regional left ventricular myocardial strain in type 1 diabetic children: a first sign of diabetic cardiomyopathy?

Decreased regional left ventricular myocardial strain in type 1 diabetic children: a first sign of diabetic cardiomyopathy?

Cardiovascular Disease Risk Factors in Youth With Diabetes Mellitus

Natural progression of cardiac autonomic neuropathy in patients with type 1 diabetes: a four-year follow-up study

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