Early pregnancy immune biomarkers in peripheral blood may predict preeclampsia

Garcia, M.D. Salazar; Mobley, Yuvon Rondreise; Henson, John; Davies, Michael L.; Skariah, Annie; Dambaeva, Svetlana; Gilman‐Sachs, Alice; Beaman, Kenneth D.; Lampley, Charles E.; Kwak‐Kim, Joanne

doi:10.1016/j.jri.2017.10.048

Cited by 81 publications

(60 citation statements)

References 34 publications

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“…Similarly, Salazar-Garcia et al (28) found PE patients had significantly higher TNFα/IL-10 cell ratio and Th17/Treg cell ratio compared to patients without PE.…”

mentioning

confidence: 87%

Disturbed Maternal Immune Milieu Early in Pregnancy Could Predict Later Development of Pre-Eclampsia and Differentiate Its Severity Grades.

Sharafeldeen¹,

Rahman²

2018

IJAR

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“…Similarly, Salazar-Garcia et al (28) found PE patients had significantly higher TNFα/IL-10 cell ratio and Th17/Treg cell ratio compared to patients without PE.…”

mentioning

confidence: 87%

Disturbed Maternal Immune Milieu Early in Pregnancy Could Predict Later Development of Pre-Eclampsia and Differentiate Its Severity Grades.

Sharafeldeen¹,

Rahman²

2018

IJAR

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“…The expression of high mobility group box 1 (HMGB1), a pro‐inflammatory danger signal, is increased in macro‐vesicles derived from trophoblast after treating placental explants with pre‐eclamptic sera . Ospina‐Prieto et al show that exosomal miR‐141 derived from foetal trophoblast is elevated in PE patients and miR‐141‐enriched trophoblast exosomes could induce T cell proliferation, indicating that placental EVs regulate maternal immune cells and cause immune disorders in pregnancy as PE is associated with systemic pro‐inflammatory environment. Kovacs et al demonstrate that PE‐MVs could interact with monocytes and modify their phenotype and function.…”

Section: Evs In Complicated Pregnancymentioning

confidence: 99%

Extracellular vesicles in normal pregnancy and pregnancy‐related diseases

Zhang

Fan

et al. 2020

J Cellular Molecular Medi

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Extracellular vesicles (EVs) are nanosized, membranous vesicles released by almost all types of cells. Extracellular vesicles can be classified into distinct subtypes according to their sizes, origins and functions. Extracellular vesicles play important roles in intercellular communication through the transfer of a wide spectrum of bioactive molecules, contributing to the regulation of diverse physiological and pathological processes. Recently, it has been established that EVs mediate foetal-maternal communication across gestation. Abnormal changes in EVs have been reported to be critically involved in pregnancy-related diseases. Moreover, EVs have shown great potential to serve as biomarkers for the diagnosis of pregnancy-related diseases.In this review, we discussed about the roles of EVs in normal pregnancy and how changes in EVs led to complicated pregnancy with an emphasis on their values in predicting and monitoring of pregnancy-related diseases.

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“…The Th1/Th2 ratio is lower in the peripheral blood of healthy pregnant women than in that of nonpregnant individuals or in women with pathological pregnancies [45]. Administration of Th1 cytokines to pregnant mice results in pregnancy loss [46].…”

Section: Effects Of Pibf On Cytokine Productionmentioning

confidence: 99%

“…Administration of Th1 cytokines to pregnant mice results in pregnancy loss [46]. In general, increased production of Th2 cytokines is a characteristic of uneventful pregnancies and favors a normal outcome [45].…”

Section: Effects Of Pibf On Cytokine Productionmentioning

confidence: 99%

The Role of Progesterone in Feto-Maternal Immunological Cross Talk

Szekeres-Barthó

2018

Med Princ Pract

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This review aims to provide a brief historical overview of the feto-maternal immunological relationship, which profoundly influences the outcome of pregnancy. The initial question posed in the 1950s by Medawar [Symp Soc Exp Biol. 1953; 7: 320–338] was based on the assumption that the maternal immune system recognizes the fetus as an allograft. Indeed, based on the association between HLA-matching and spontaneous miscarriage, it became obvious that immunological recognition of pregnancy is required for a successful gestation. The restricted expression of polymorphic HLA antigens on the trophoblast, together with the presence of nonpolymorphic MHC products, excludes recognition by both T and NK cells of trophoblast-presented antigens; however, γδ T cells, which constitute the majority of decidual T cells, are likely candidates. Indeed, a high number of activated, progesterone receptor-expressing γδ T cells are present in the peripheral blood of healthy pregnant women and, in the presence of progesterone, these cells secrete an immunomodulatory protein called progesterone-induced blocking factor (PIBF). As early as in the peri-implantation period, the embryo communicates with the maternal immune system via PIBF containing extracellular vesicles. PIBF contributes to the dominance of Th2-type reactivity which characterizes normal pregnancy by inducing increased production of Th2 cytokines. The high expression of this molecule in the decidua might be one of the reasons for the low cytotoxic activity of decidual NK cells.

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Early pregnancy immune biomarkers in peripheral blood may predict preeclampsia

Cited by 81 publications

References 34 publications

Disturbed Maternal Immune Milieu Early in Pregnancy Could Predict Later Development of Pre-Eclampsia and Differentiate Its Severity Grades.

Disturbed Maternal Immune Milieu Early in Pregnancy Could Predict Later Development of Pre-Eclampsia and Differentiate Its Severity Grades.

Extracellular vesicles in normal pregnancy and pregnancy‐related diseases

The Role of Progesterone in Feto-Maternal Immunological Cross Talk

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