2023
DOI: 10.3390/ijms241814054
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Early Pregnancy Markers in the Serum of Ewes Identified via Proteomic and Metabolomic Analyses

Yaying Zhai,
Fan Xia,
Luting Shi
et al.

Abstract: The diagnosis of ewes’ pregnancy status at an early stage is an efficient way to enhance the reproductive output of sheep and allow producers to optimize production and management. The techniques of proteomics and metabolomics have been widely used to detect regulatory factors in various physiological processes of animals. The aim of this study is to explore the differential metabolites and proteins in the serum of pregnant and non-pregnant ewes by proteomics and metabolomics. The serum of ewes at 21, 28 and 3… Show more

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“…Azahelicenium salts have been described to intercalate into DNA and to have anticancer effects . Indolophenanthridines and their derivatives also show interesting optophysical properties and biological activity: They have been identified as pregnancy markers in sheep and interact with DNA topoisomerase I and ctDNA, which makes them cytotoxic to leukemia cells and Leishmania spp., respectively. Moreover, related heterocyclic systems appear to be of great industrial interest for organic electronics …”
mentioning
confidence: 99%
“…Azahelicenium salts have been described to intercalate into DNA and to have anticancer effects . Indolophenanthridines and their derivatives also show interesting optophysical properties and biological activity: They have been identified as pregnancy markers in sheep and interact with DNA topoisomerase I and ctDNA, which makes them cytotoxic to leukemia cells and Leishmania spp., respectively. Moreover, related heterocyclic systems appear to be of great industrial interest for organic electronics …”
mentioning
confidence: 99%