Early Prenatal Phthalate Exposure, Sex Steroid Hormones, and Birth Outcomes

Sathyanarayana, Sheela; Butts, Samantha; Wang, Christina; Barrett, Emily S.; Nguyen, Ruby H.N.; Schwartz, Stephen M.; Haaland, Wren; Swan, Shanna H.

doi:10.1210/jc.2016-3837

Cited by 97 publications

(86 citation statements)

References 54 publications

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“…18 Prenatal phthalate exposure has been associated with a shorter male anogenital distance [19][20][21] and male genital defects. 22 Such changes to the male genitals may arise from phthalate-induced suppression of fetal gonadal testosterone synthesis. 23 Antiandrogenic phthalates have been shown to disrupt testosterone-dependent brain development, 24 and associations between prenatal exposure and sex-dependent neurodevelopmental end points have been reported.…”

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confidence: 99%

Association of Prenatal Phthalate Exposure With Language Development in Early Childhood

et al. 2018

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Prenatal exposure to phthalates has been associated with neurodevelopmental outcomes, but little is known about the association with language development. OBJECTIVE To examine the association of prenatal phthalate exposure with language development in children in 2 population-based pregnancy cohort studies. DESIGN, SETTING, AND PARTICIPANTS Data for this study were obtained from the Swedish Environmental Longitudinal Mother and Child, Asthma and Allergy (SELMA) study conducted in prenatal clinics throughout Värmland county in Sweden and The Infant Development and the Environment Study (TIDES) conducted in 4 academic centers in the United States. Participants recruited into both studies were women in their first trimester of pregnancy who had literacy in Swedish (SELMA) or English or Spanish (TIDES). This study included mothers and their children from both the SELMA study (n = 963) and TIDES (n = 370) who had complete data on prenatal urinary phthalate metabolite levels, language delay, and modeled covariables.

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Association of Prenatal Phthalate Exposure With Language Development in Early Childhood

et al. 2018

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“…Bottlenose dolphin exposure to DEHP and DEP is concerning due to laboratory and human studies linking these chemicals to adverse health effects including altered hormone synthesis and transport (ATSDR, ; Meeker & Ferguson, ; Sathyanarayana et al, ], male genital developmental abnormalities (ATSDR, ; Swan, ), reproductive impairment (e.g., lower birth weight, Messerlian et al, ; preterm birth, Meeker et al, ; delayed time to pregnancy, Thomsen et al, ; pregnancy loss, H. Gao et al, ), and liver toxicoses including liver cancer (ATSDR, ). In fact, MEHP concentrations measured in the dolphins in this study (GM = 1.9 ng/ml; Range = 0.9–5.9 ng/ml) were at comparable levels reported to be associated with a reduced probability of reproductive success in humans (Hauser et al, ).…”

Section: Discussionmentioning

confidence: 99%

“…Certain phthalates have been identified as reproductive and developmental toxicants and endocrine disruptors. Mammalian toxicological studies have suggested that some phthalate compounds can disrupt the secretion of thyroid and growth hormones (Mathieu-Denoncourt et al, 2015), alter steroidogenesis and lower circulating concentrations of testosterone (Bell, 1982;Meeker & Ferguson, 2014;Sathyanarayana et al, 2017), and impact the production and metabolism of estrogen (Sathyanarayana et al, 2017). The consequences of these hormonal changes may result in reduced fertility, abnormal reproductive organ development, and impacts on pregnancy outcomes (Bell, 1982;Latini et al, 2004).…”

Section: Introduction To Phthalates and Potential Health Concernsmentioning

confidence: 99%

Urinary Phthalate Metabolites in Common Bottlenose Dolphins (Tursiops truncatus) From Sarasota Bay, FL, USA

et al. 2018

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Phthalates are chemical additives to common consumer goods including cleaning products, cosmetics, personal care products, and plastic. Because they are not chemically bound to these products and are widely used, the potential for environmental contamination is significant. Phthalates and their metabolites have been associated with endocrine disruption and reproductive impairment, among other adverse health effects, in laboratory animals and human epidemiologic studies. Common bottlenose dolphins (Tursiops truncatus) are vulnerable to environmental pollutants due to their apex position in the food chain, long life spans, and habitat overlap with developed coastal areas. The objective of this study was to quantify phthalate metabolite concentrations in urine collected from bottlenose dolphins in Sarasota Bay, Florida, during May 2016 (n = 7) and May 2017 (n = 10). Screening of nine phthalate monoester metabolites in bottlenose dolphin urine was performed by liquid chromatography tandem mass spectrometry using methods adapted from those used for analyzing human samples. At least one phthalate metabolite was detected in 71% of the dolphins sampled across both years, with the highest concentrations detected for monoethyl phthalate (MEP; GM = 5.4 ng/ml; 95%CI: 1.3–22.0 ng/ml) and mono‐(2‐ethylhexyl) phthalate (MEHP; GM = 1.9 ng/ml; 95%CI: 1.1–3.2 ng/ml). These data demonstrate exposure to two of the most commonly used phthalates in commercial manufacturing, diethyl phthalate (DEP) and di‐2‐ethylhexyl phthalate (DEHP). This study establishes methods for urinary detection of phthalate metabolites in marine mammals and provides baseline data to address a significant and growing, yet poorly understood, health threat to marine wildlife.

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“…Previous studies have shown associations between markers of phthalate and BPA exposure and altered steroid hormone levels in adults (Ehrlich et al 2012; Meeker et al 2009; Mok-Lin et al 2010; Pan et al 2006; Sathyanarayana et al 2014; Sathyanarayana et al 2017), as well as associations between in utero or early life exposure and hormone levels in infants (Araki et al 2014; Lin et al 2011; Main et al 2006). However, few studies have investigated relationships between phthalate or BPA exposure during in utero development and subsequent hormone levels during puberty, a time at which steroid hormones play an essential role in reproductive development.…”

Section: Introductionmentioning

confidence: 99%

Phthalate and bisphenol A exposure during in utero windows of susceptibility in relation to reproductive hormones and pubertal development in girls

Watkins

Sánchez

Téllez-Rojo

et al. 2017

Environmental Research

114

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Background Over the past several decades, the age of pubertal onset in girls has shifted downward worldwide. As early pubertal onset is associated with increased risky behavior and psychological issues during adolescence and cardiometabolic disease and cancer in adulthood, this is an important public health concern. Exposure to endocrine disrupting chemicals during critical windows of in utero development may play a role in this trend. Our objective was to investigate trimester-specific phthalate and BPA exposure in relation to pubertal development among girls in the Early Life Exposure in Mexico to Environmental Toxicants (ELEMENT) birth cohort. Methods We measured maternal urinary phthalate metabolites and BPA in samples collected during the first, second, and third trimesters of pregnancy. To assess reproductive development among their female children, we measured serum testosterone, estradiol, dehydroepiandrosterone sulfate (DHEA-S), inhibin B, and sex hormone-binding globulin (SHBG), and assessed sexual maturation, including Tanner staging for breast and pubic hair development and menarche status, at age 8–13 years (n=120). We used linear and logistic regression to examine measures of trimester-specific in utero exposure as predictors of peripubertal hormone levels and pubertal onset, respectively. In secondary analyses, we evaluated estimated exposure at the midpoint of the first trimester and rates of change in exposure across pregnancy in relation to outcomes. Results Several phthalate metabolites measured throughout in utero development were associated with higher serum testosterone concentrations, while a number of metabolites measured in the third trimester were associated with higher DHEA-S. For example, an interquartile range (IQR) increase in mean monoethyl phthalate (MEP) levels across pregnancy was associated with 44% higher peripubertal testosterone (95% CI: 13–83%), while an IQR increase in di-2-ethylhexyl phthalate metabolites (ΣDEHP) specifically in the third trimester was associated with 25% higher DHEA-S (95%CI: 4.7–47%). In IQR increase in mean mono-2-ethylhexyl phthalate (MEHP) levels across pregnancy was associated with lower odds of having a Tanner Stage >1 for breast development (OR=0.32, 95%CI: 0.11–0.95), while MEHP in the third trimester was associated with higher odds of having a Tanner Stage >1 for pubic hair development (OR=3.76, 95%CI: 1.1–12.8). Results from secondary analyses were consistent with findings from our main analysis. Conclusion These findings suggest that female reproductive development may be more vulnerable to the effects of phthalate or BPA exposure during specific critical periods of in utero development. This highlights the need for comprehensive characterizations of in utero exposure and consideration of windows of susceptibility in developmental epidemiological studies. Future research should consider repeated measures of in utero phthalate and BPA exposure within each trimester and across pregnancy.

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Early Prenatal Phthalate Exposure, Sex Steroid Hormones, and Birth Outcomes

Cited by 97 publications

References 54 publications

Association of Prenatal Phthalate Exposure With Language Development in Early Childhood

Association of Prenatal Phthalate Exposure With Language Development in Early Childhood

Urinary Phthalate Metabolites in Common Bottlenose Dolphins (Tursiops truncatus) From Sarasota Bay, FL, USA

Phthalate and bisphenol A exposure during in utero windows of susceptibility in relation to reproductive hormones and pubertal development in girls

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