Early priming of asthma and respiratory allergies: Future aspects of prevention

Abstract

The workshop was sponsored and organized by the European Forum for Education and Research in Allergy and Airway Disease (EUFOREA) and the EAACI-Clemens von Pirquet Foundation. A honoraria was paid to each active participant.

Pre-asthma: a useful concept for prevention and disease-modification? A EUFOREA paper. Part 1—allergic asthma

“…Other areas worth investigation relate to micro- organisms. Some observations in a previous EUFOREA paper ( 159 ) were that the one allergen still to be avoided was latex in children with spina bifida and that there were anti- wheezing effects of bacterial mucosal vaccines in recurrently wheezing pre-school children ( 160 ). Although not all early wheezing is asthma and the children in this study were non- atopic, it does show an effect of bacterial molecules upon innate immunity.…”

Editorial comments on: “Immune‐related microRNAs in breast milk and their relation to regulatory T cells in breastfed children”

“…3 In the quest of deciphering the beneficial mechanisms behind the potential preventive effect of breast milk, various authors have recently evoked the role of metabolites such as caprylate or acetate, 4 or of modulation of IgA levels, 5 but also potentially of micro-RNAs and the gut microbiome. 6,7 We highlight here as editor's choice the recent study by Ahlbers et al which postulated that the expression of immune-related miRNAs in breast milk is influenced by pre-and postnatal supplementation with Limosilactobacillus reuteri and omega-3 polyunsaturated fatty acids through immunomodulation by infant's regulatory T cells. 8 miRNA are small noncoding RNAs that can modulate gene expression on a posttranscriptional level.…”

“…Among these, lactation with human breast milk finds is widely supported due to its many beneficial aspects; however, controversy still remains about whether breastfeeding can prevent the development of allergic disease 3 . In the quest of deciphering the beneficial mechanisms behind the potential preventive effect of breast milk, various authors have recently evoked the role of metabolites such as caprylate or acetate, 4 or of modulation of IgA levels, 5 but also potentially of micro‐RNAs and the gut microbiome 6,7 …”

Editorial comments on “Sensitization trajectories to multiple allergen components in a population‐based birth cohort”

“…Consequently, the risk of developing immunoglobulin E (IgE)‐mediated allergy to specific airborne allergens varies by geographic location. Climate also affects our indoor environment, for example by generating high levels of house dust mites (HDM), which is a prominent risk factor for persistent allergic reactions of rhinoconjunctivitis and asthma 1,2 …”

“…Climate also affects our indoor environment, for example by generating high levels of house dust mites (HDM), which is a prominent risk factor for persistent allergic reactions of rhinoconjunctivitis and asthma. 1,2 In the current issue of Pediatric Allergy and Immunology, Farraia with colleagues present novel trajectories of IgE sensitization based on microarray analysis of 112 molecular components in a population-based birth cohort of Northern Portugal, to compare with the already studied trajectories in Northern Europe. The data-driven approach identified five trajectories of IgE sensitization to HDM and/or grass pollen between 4 and 10 years of age.…”