Early Probiotic Supplementation for Eczema and Asthma Prevention: A Randomized Controlled Trial

Cabana, Michael D.; McKean, Michelle; Caughey, Aaron B.; Fong, Lawrence; Lynch, Susan V.; Wong, Angela; Leong, Russell; Boushey, Homer A.; Hilton, Joan F.

doi:10.1542/peds.2016-3000

Cited by 124 publications

(101 citation statements)

References 28 publications

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“…Coming enthusiastically from these animal studies into the human system, the application of probiotics to high-risk children in the first 6 months of life did not show any significant differences for asthma incidence at the age of 5 years, although a trend was found with 17.4% affected by asthma in the control group vs. 9.7% in the LGG-treated children [149].…”

Section: Asthma Prevention I) Probioticsmentioning

confidence: 95%

Dysbiosis of the gut and lung microbiome has a role in asthma

et al. 2020

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Worldwide 300 million children and adults are affected by asthma. The development of asthma is influenced by environmental and other exogenous factors synergizing with genetic predisposition, and shaping the lung microbiome especially during birth and in very early life. The healthy lung microbial composition is characterized by a prevalence of bacteria belonging to the phyla Bacteroidetes, Actinobacteria, and Firmicutes. However, viral respiratory infections are associated with an abundance of Proteobacteria with genera Haemophilus and Moraxella in young children and adult asthmatics. This dysbiosis supports the activation of inflammatory pathways and contributes to bronchoconstriction and bronchial hyperresponsiveness. Exogenous factors can affect the natural lung microbiota composition positively (farming environment) or negatively (allergens, air pollutants). It is evident that also gut microbiota dysbiosis has a high influence on asthma pathogenesis. Antibiotics, antiulcer medications, and other drugs severely impair gut as well as lung microbiota. Resulting dysbiosis and reduced microbial diversity dysregulate the bidirectional crosstalk across the gut-lung axis, resulting in hypersensitivity and hyperreactivity to respiratory and food allergens. Efforts are undertaken to reconstitute the microbiota and immune balance by probiotics and engineered bacteria, but results from human studies do not yet support their efficacy in asthma prevention or treatment. Overall, dysbiosis of gut and lung seem to be critical causes of the increased emergence of asthma.

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Section: Asthma Prevention I) Probioticsmentioning

confidence: 95%

Dysbiosis of the gut and lung microbiome has a role in asthma

et al. 2020

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“…A study, however, showed that continuous administration of 10 7 colony‐forming units Lactobacillus gasseri for 4 weeks prevented Dermatophagoides pteronyssinus (house dust mites) induced inflammation of airway in mouse models of allergic asthma . However, a randomized trial on humans showed that Lactobacillus supplementation for the first 6 months does not seem to cause a decreased rate of development of asthma . In terms of increased abundance of Bacteriodaceae , a separate study showed that children that develop asthma show low diversity of gut microbiota with predominance of Bacteriodaceae .…”

Section: Dysbiosis and The Development Of Asthma In Children Born To mentioning

confidence: 99%

“…44 However, a randomized trial on humans showed that Lactobacillus supplementation for the first 6 months does not seem to cause a decreased rate of development of asthma. 45 In terms of increased abundance of Bacteriodaceae, a separate study showed that children that develop asthma show low diversity of gut microbiota with predominance of Bacteriodaceae. 46 This shows that an asthmatic mother can increase the chance of the child of developing asthma in a non-genetic mechanism via increasing abundance of Bacteriodaceae and decreasing that of Lactobacillus.…”

Section: Development Of Asthma In Children Born To Asthmatic Mothersmentioning

confidence: 99%

The role of gut microbiota in atopic asthma and allergy, implications in the understanding of disease pathogenesis

et al. 2020

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Asthma is a clinical syndrome characterized by chronic airway inflammation. There is mounting evidence on the role of microbiota in the development of asthma. This review focuses on the role of microbiota in maintaining the integrity of the epithelia and their role in regulating the immune response. The review compiles data from multiple studies on the role of microbiota in the innate immune response and the development and differentiation of CD4+ T cells, a major component of the adaptive arm of the immune response. As a result of dysbiosis, invariant natural killer T cells may induce T helper 2 cell differentiation and immunoglobulin E isotype switching through the release of interleukin‐4 and interleukin‐13. Furthermore, degradation of immunoglobulin A antibodies, increased circulating mast cells and basophils, and inflammation are among other mechanisms by which dysbiosis can induce or exacerbate asthma. After explaining the underlying mechanisms, the review derives conclusions from studies that investigate dysbiosis in infancy and the development of asthma later in life. The review also includes studies that investigate asthmatic mothers and the development of asthma in children and the role of dysbiosis in that regard. Finally, the review explains the statistical relationship between eczema and asthma through multiple studies that investigate the role of dysbiosis in both atopic states. This review provides insight into the role of dysbiosis in asthma, and an understanding that is required to establish clinical trials which aim to modulate the gut microbiota as a means of preventing and treating asthma.

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“…Thus, L. plantarum IS-10506 was able to reduce clinical symptoms in children diagnosed with AD and therefore with potential to treat this disease (Prakoeswa et al 2017). Cabana et al (2017) evaluated the effectiveness of daily L. rhamnosus GG supplementation for the first 6 months of life to decrease eczema incidence, a potential early marker of asthma. The intervention infants received a daily dose of L. rhamnosus GG (1 × 10 9 CFU) and inulin (225 mg), and the control infants received inulin (325 mg) alone.…”

Section: Oral Administration Of Probiotics and Prebiotics For The Trementioning

confidence: 99%

Probiotics and prebiotics potential for the care of skin, female urogenital tract, and respiratory tract

et al. 2019

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The prebiotics and probiotics market is constantly growing due to the positive effects of its consumption on human health, which extends beyond the digestive system. In addition, the synbiotic products market is also expanding due to the synergistic effects between pre-and probiotics that provide additional benefits to consumers. Pre-and probiotics are being evaluated for their effectiveness to treat and prevent infectious diseases in other parts of the human body where microbial communities exist. This review examines the scientific data related to the effects of pre-and probiotics on the treatment of diseases occurring in the skin, female urogenital tract, and respiratory tract. The evidence suggests that probiotics consumption can decrease the presence of eczema in children when their mothers have consumed probiotics during pregnancy and lactation. In women, probiotics consumption can effectively prevent recurrent urinary tract infections. The consumption of synbiotic products can reduce respiratory tract infections and their duration and severity. However, the outcomes of the meta-analyses are still limited and not sufficiently conclusive to support the use of probiotics to treat infectious diseases. This is largely a result of the limited number of studies, lack of standardization of the studies, and inconsistencies between the reported results. Therefore, it is advisable that future studies consider these shortcomings and include the evaluation of the combined use of pre-and probiotics.

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Early Probiotic Supplementation for Eczema and Asthma Prevention: A Randomized Controlled Trial

Abstract: For high-risk infants, early LGG supplementation for the first 6 months of life does not appear to prevent the development of eczema or asthma at 2 years of age.

Cited by 124 publications

References 28 publications

Dysbiosis of the gut and lung microbiome has a role in asthma

Dysbiosis of the gut and lung microbiome has a role in asthma

The role of gut microbiota in atopic asthma and allergy, implications in the understanding of disease pathogenesis

Probiotics and prebiotics potential for the care of skin, female urogenital tract, and respiratory tract

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