Early prognosis of unstable angina patients with positive Helicobacter pylori IgG values

Kaulgud, Ram S; Kamath, Ramachandra

doi:10.7439/ijbr.v4i3.235

Cited by 2 publications

(2 citation statements)

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“…Before inoculation, the animals were given orally 1 mL of 0.2 M NaHCO 3 to neutralize stomach pH. In total, 40 animals were used: 10 uninfected (control) and 30 with H. pylori infection lasting 7 days (10) or 28 days (20). Stool and blood samples as well as gastric tissue (after euthanasia) were collected in the above time points.…”

Section: H Pylori Infection In Caviae Porcellusmentioning

confidence: 99%

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Antibodies towards TVLLPVIFF Amino Acid Sequence of TNF Receptor Induced by Helicobacter pylori in Patients with Coronary Heart Disease

Gonciarz

Tomaszewska

Krupa

et al. 2022

JCM

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Background: Molecular mimicry between Helicobacter pylori (Hp) and the host components resulting in induction of cross-reacting antibodies has been suggested as accessory mechanism in the development of coronary heart disease (CHD). A potential target for antibodies induced during Hp infection by the components of these bacteria might be amino acid sequence TVLLPVIFF (P1) of tumor necrosis factor receptor (TNFR), which is exposed on vascular endothelium and immunocompetent cells, driving inflammation. Aim: To examine whether anti-P1 IgG are induced during Hp infection in CHD patients. Methods: Sera from CHD patients infected with Hp (54) vs. sera of uninfected healthy donors (22) were tested by the ELISA for anti-H. pylori antibodies, anti-P1 IgG, and for antibodies towards control sequence IAKEGFEKIS (P2). Sera of Caviae porcellus infected experimentally with Hp (30) or uninfected (10) were included into this study. The same serum samples, which were positive for anti-P1 IgG, were adsorbed with Hp and then subjected to the ELISA. The biological activity of anti-P1 IgG was assessed in complement (C1q) binding assay. Results: Sera of 43 CHD patients seropositive for anti-Hp IgG contained anti-P1 IgG binding C1q. Additionally, 10 serum samples of animals seropositive for anti-Hp IgG contained anti-P1 IgG. Anti-P1 IgG in tested sera were neutralized by their adsorption with Hp. Conclusion: In CHD patients infected with Hp, antibodies cross-reacting with TNFR common sequence are produced. Further studies are necessary to define immunogenic Hp determinants and to confirm possible cellular effects of cross-reacting antibodies.

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Section: H Pylori Infection In Caviae Porcellusmentioning

confidence: 99%

“…Majority of CHD patients are exposed to H. pylori since they produce antibodies towards various H. pylori antigens [7,[18][19][20]. However, data that do not confirm this correlation are also available [21,22].…”

Section: Introductionmentioning

confidence: 99%