Early Reactive Changes at Myelin Sheaths Gaps (nodes of Ranvier) of Nerve Fibers (a supravital study)

Os, Sotnikov; Kokurina, T. N.; Solovyova, Irina; Sergeeva, S. S.

doi:10.1007/s11055-012-9634-7

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2015

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“…; Sotnikov et al . ). The illustrated F / F rest recordings show the time course (upper traces) and spatial extent (lower traces) of stimulation‐induced [Ca 2+ ] elevations in this axon before and after LPC exposure.…”

Section: Resultsmentioning

confidence: 97%

Stimulation‐induced Ca²⁺ influx at nodes of Ranvier in mouse peripheral motor axons

Zhang

David

2015

The Journal of Physiology

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Key pointsr In peripheral myelinated axons of mammalian spinal motor neurons, Ca 2+ influx was thought to occur only in pathological conditions such as ischaemia. influx, some active in normally-myelinated axons (T-type channels, NCX), others active only when exposed by myelin disruption (L-type channels). The modest axoplasmic peri-nodal [Ca 2+ ] elevations measured in intact motor axons might mediate local responses to axonal activation. The larger [Ca 2+ ] elevations measured after myelin disruption might, over time, contribute to the axonal degeneration observed in peripheral demyelinating neuropathies.

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Section: Resultsmentioning

confidence: 97%

Stimulation‐induced Ca²⁺ influx at nodes of Ranvier in mouse peripheral motor axons

Zhang

David

2015

The Journal of Physiology

View full text Add to dashboard Cite

show abstract

Early Reactive Changes at Myelin Sheaths Gaps (nodes of Ranvier) of Nerve Fibers (a supravital study)

Cited by 1 publication

References 11 publications

Stimulation‐induced Ca²⁺ influx at nodes of Ranvier in mouse peripheral motor axons

Stimulation‐induced Ca²⁺ influx at nodes of Ranvier in mouse peripheral motor axons

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Early Reactive Changes at Myelin Sheaths Gaps (nodes of Ranvier) of Nerve Fibers (a supravital study)

Cited by 1 publication

References 11 publications

Stimulation‐induced Ca2+ influx at nodes of Ranvier in mouse peripheral motor axons

Stimulation‐induced Ca2+ influx at nodes of Ranvier in mouse peripheral motor axons

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Stimulation‐induced Ca²⁺ influx at nodes of Ranvier in mouse peripheral motor axons

Stimulation‐induced Ca²⁺ influx at nodes of Ranvier in mouse peripheral motor axons