Early recognition of PIMS-TS: a single centre retrospective review

Abstract

IntroductionResearch into paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) has focused on tertiary level management. This review reports on symptoms and investigations at presentation.MethodsSingle centre retrospective case note analysis of patients fulfilling PIMS-TS diagnostic criteria from March to May 2020 in a London district level university hospital.ResultsSix patients presented in the week prior to their final diagnosis with fever and non-specific symptoms. Raised C-reactive protein (CRP), lymphopenia and hyponatraemia were noted. Kawasaki-like symptoms were under-represented in all patients.InterpretationThe results suggest that a proportion of children with early PIMS-TS present with a non-specific febrile illness and abnormal blood results. Further research is needed to determine the most appropriate identification and follow-up of these children.

“Lymphocyte * Neutrophil” count decreased in SARS‐CoV‐2 Omicron patients in Shanghai with no significant change in CRP and SAA

“…6 CRP has been suggested to be associated with respiratory function (PaO 2 /FiO 2 ), is a predictor of respiratory failure 24 , and it's elevation is widely used as an inflammatory factor in SARS-CoV-2 infection. [25][26][27] In our study, we found that CNR was increased compared with the negative group, and the difference was statistically significant (p < 0.05).…”

“…CAR (C‐reactive protein to serum albumin ratio) has high sensitivity and specificity in the diagnosis of diabetes nephropathy 6 . CRP has been suggested to be associated with respiratory function (PaO 2 /FiO 2 ), is a predictor of respiratory failure 24 , and it's elevation is widely used as an inflammatory factor in SARS‐CoV‐2 infection 25–27 …”

Hospitalized Children with Critical SARS-CoV-2 Infection Cared for in a Limited Resource Setting: Multicenter Cohort Study

“…Several epidemiological and clinical similarities were identi ed between this study and others [1][2][3][27][28][29][30], with an emphasis on the predominance of males [3,4,30], individuals of mixed race [5,31], clinical admissions [6,32], of comorbidities [7,33], pronounced gastrointestinal and skin manifestations [27,30], high for vasoactive drugs [26,31], as well of circulatory shock (mainly [32,33], presence ground-glass pneumonia [34,35], long stay and PICU, and need for ventilatory support [2][3][4][5][6]36].…”