1978
DOI: 10.1161/01.cir.57.2.332
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Early redistribution of thallium-201 after temporary ischemia.

Abstract: To define the time course of redistribution of thallium-201 (201Tl), ischemia was induced in seven pigs by temporary occlusion of the circumflex coronary artery. After 1 1/2 min of occlusion 201Tl and labeled microspheres were injected into the left atrium. Flow was re-established 4 min after occlusion. Prior to reflow, the relative activities of 201Tl and microspheres in the ischemic area were similar, but as early as 5 min after reflow the relative 201Tl activity was considerably higher than the relative mic… Show more

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Cited by 79 publications
(13 citation statements)
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“…Previous reports using animal models have studied this phenomenon which has become known as "Tl-201 redistribution," and demonstrated its time course when occlusion was followed shortly thereafter by reflow. (Pohost et al, 1977;Schwartz et al, 1978).…”
mentioning
confidence: 99%
“…Previous reports using animal models have studied this phenomenon which has become known as "Tl-201 redistribution," and demonstrated its time course when occlusion was followed shortly thereafter by reflow. (Pohost et al, 1977;Schwartz et al, 1978).…”
mentioning
confidence: 99%
“…The use of the redistni bution kinetics of 201T1 for the performance of a singlo-dose rest and stress cardiac study has been studied by several investigators [7,12]. In one of these series, qualitatively, ‘¿ ‘¿ the nest images appeared similar to the 4â€"6 hr postexencise images previously obtained' ‘¿ [7].…”
Section: Discussionmentioning
confidence: 87%
“…Thus an appreciation of the alterations in perfusion with stress with out a separate true resting study seems feasible. accepted contention that the influx and eflux of the tracer is more likely closely related to the pathophysiologic perfusion state of the tissue compartment involved [12].…”
Section: Discussionmentioning
confidence: 99%
“…Specifically, we chose to investigate (1) how variations in the timning of 201T1 injection with relation to the cessation of ischemia, and (2) how the presence of reactive hyperemia after ischemia reversal would influence the formation of the initial 201T1 defect. The dogs were sacrificed for LC/LAD 201T1 determinations 6-8 minutes after injection.…”
Section: Discussionmentioning
confidence: 99%