Early Repolarization in Young Children with Attention-Deficit/Hyperactivity Disorder Versus Normal Controls: A Retrospective Preliminary Chart Review Study

Nahshoni, Eitan; Sclarovsky, Samuel; Spitzer, Sara; Zalsman, Gil; Strasberg, Boris; Weizman, Abraham

doi:10.1089/cap.2009.0034

Cited by 15 publications

(15 citation statements)

References 22 publications

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“…Our results are applicable to a mostly minority vulnerable young urban population with ADHD who had an ECG done for cardiac screening purposes. The overall prevalence of ERPA in our ADHD patients (30.5%) suggest that our study group had similar results to those reported by Nahshoni et al 6 (32%) in Israel. They reported that a small group of children with ADHD (n = 50) had significantly higher proportion of early repolarization (ST elevation) when compared with apparently healthy control subjects (32% vs 13%, P = .012).…”

Section: Discussionsupporting

confidence: 91%

“…We could find only one study that suggested that ERPA is associated with ADHD. After analyzing the electrocardiogram (ECG) tracings in a small sample of children (n = 50), Nahshoni et al 6 suggested that “the rates of early repolarization (ER) in children with ADHD is significantly higher than in normal controls (32% vs 13%, P = .012).” Our study had 2 aims: first, to determine if ERPAs were more likely present among children and adolescents diagnosed with ADHD when compared with non-ADHD children of similar demographic backgrounds. Second, to asses if children and adolescents with ADHD whose parents report severe attention difficulties and/or hyperactivity/impulsivity or “significant worry regarding their child behavior” (Parental Worry) are more likely to have ERPAs in their surface ECG when compared with other ADHD patients with mild to moderate dysfunction.…”

Section: Introductionmentioning

confidence: 99%

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Cardiac Early Repolarization Pattern Anomalies Among Children and Adolescents With and Without Attention-Deficit Hyperactivity Disorder: A Community Observational Study

Isart¹,

Ramos²,

Isart-Infante³

2019

Global Pediatric Health

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Our research had 2 aims, first, to determine if electrocardiographic early repolarization pattern anomalies (ERPAs) were more likely present among children and adolescents diagnosed with attention-deficit hyperactivity disorder (ADHD; n = 416) when compared with non-ADHD children (n = 187), and second, to asses if ADHD patients whose parents report severe ADHD psychometric scores were more likely to have ERPA in their surface ECG (electrocardiography) when compared with other ADHD patients with mild to moderate dysfunction or no dysfunction. In our unmatched case-control study, ERPA was recognized when there was an end QRS notch (J wave) or slur on the downslope of a prominent R wave with and without ST-segment elevation and the peak of the notch or J wave (Jp) ≥0.1 mV in ≥2 contiguous leads, excluding V1-V3 anterior lead, and QRS duration (measured in leads in which a notch or slur is absent) <120 ms or ST-segment elevation >0.1 mV in ≥2 contiguous leads, excluding V1-V3, and QRS duration <120 ms. The DSM-IV (Diagnostic and Statistical Manual of Mental Disorders, 4th edition) criteria were used to diagnose ADHD. Our data analysis suggested a significant association between ERPA presence and ADHD (n = 603, P = .020). Our logistic regression model suggests that patients with ERPA (n = 167) were 2.778 times more likely to have a diagnosis of ADHD after controlling for age, gender, and ethnicity (95% confidence interval for odds ratio 1.087-7.100, P = .033). Multiple regression models suggested that age, P < .001; gender, P < .001; ERPA, P = .004; and ERPA leads number, P = .022, were significant predictors of global parental ADHD worry scale. Hispanic and black ethnicity were not significant predictors. Consequently, the presence of ERPA should be reported in all ECGs done in children and adolescents for prospective behavioral phenotype and/or arrhythmia risk stratification analysis.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Cardiac Early Repolarization Pattern Anomalies Among Children and Adolescents With and Without Attention-Deficit Hyperactivity Disorder: A Community Observational Study

Isart¹,

Ramos²,

Isart-Infante³

2019

Global Pediatric Health

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“…during sleep or after meals. An association with pathological conditions of autonomic imbalance, including spinal cord injuries [5] and attention deficit/hyperactivity disorder [6] , is also reported. Recent investigations found an elevated risk of malignant ventricular arrhythmia [4] , and in a community-based study the risk of death from any cause was significantly increased in subjects with ER 1 0.2 mV in the inferior leads [7] .…”

Section: Discussionmentioning

confidence: 90%

Early Repolarisation Syndrome and Ischemic Stroke: Is There a Link?

Kallmünzer¹,

Kuramatsu²,

Breuer³

et al. 2011

Cerebrovasc Dis

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“…The copyright holder for this preprint this version posted July 17, 2020. ; https://doi.org/10.1101/2020.07.16.20155838 doi: medRxiv preprint 5 sudden cardiac death [11,12]. Recently, it has been reported that there are associations between ERP and attention-deficit hyperactivity disorder [13,14],and the patients with suicidal risks [15].…”

Section: Introductionmentioning

confidence: 99%

Early Repolarization Pattern is Associated with Schizophrenia: A Single Center Experience in Japan

Kameyama

Sugimoto

Inamura

et al. 2020

Preprint

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Introduction Recent studies have shown a high frequency of abnormal electrocardiograms in patients with schizophrenia. The objective of this study was to associate schizophrenia diagnoses with early repolarization patterns in a sample of hospitalized patients from a single hospital in Japan. Methods We conducted a retrospective age, sex and coronary risk factors matched case-control study on 85 patients with schizophrenia and 89 controls from medical checkups. First, we compared the presence of early repolarization patterns in both groups. Secondly, we elucidated an association between the presence of an early repolarization pattern and clinical findings in the patients' groups. We also evaluated J-point elevation patterns. Results As a result, we found that both early repolarization patterns and J-point elevation patterns observed were significantly higher in the schizophrenic group than in the matched control group (early repolarization pattern 23;6 P < 0.001; J-point elevation pattern 34:12; P = 0.001). After multivariable logistic regression among the patients and controls, schizophrenia was the independent predictor for early repolarization pattern (P = 0.001) and J-point elevation (P < 0.001). Among the patients, the independent predictor for early repolarization pattern was psychiatric family history (P = 0.006), while older age (P = 0.038) and psychiatric family history (P = 0.014) were predictors for J-point elevation patterns. Conclusion These findings suggest that an association between early repolarization pattern or J-point elevation pattern and schizophrenia in a single Japanese center.

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Early Repolarization in Young Children with Attention-Deficit/Hyperactivity Disorder Versus Normal Controls: A Retrospective Preliminary Chart Review Study

Abstract: The rate of ER in children with ADHD is significantly higher than in normal controls. Its clinical significance awaits further research.

Cited by 15 publications

References 22 publications

Cardiac Early Repolarization Pattern Anomalies Among Children and Adolescents With and Without Attention-Deficit Hyperactivity Disorder: A Community Observational Study

Cardiac Early Repolarization Pattern Anomalies Among Children and Adolescents With and Without Attention-Deficit Hyperactivity Disorder: A Community Observational Study

Early Repolarisation Syndrome and Ischemic Stroke: Is There a Link?

Early Repolarization Pattern is Associated with Schizophrenia: A Single Center Experience in Japan

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